Glutathione S-transferase T1-null seems to be associated with graft failure in hematopoietic SCT

Influence of glutathioneS-transferase A1, P1, M1, T1 polymorphisms on oral busulfan pharmacokinetics in children with congenital hemoglobinopathies undergoing hematopoietic stem cell transplantation

“…Interestingly, as seen in Table II, the patients in this study demonstrated a 2:1 chance of having a GSTM1 ‐null genotype compared to healthy controls. In the present cohort, as previously reported 29, five children (27.7%) experienced graft rejection, all of which shared a GSTT1 ‐null genotype. Three of these children successfully engrafted after a second stem cell transplantation (Table I).…”

“…In the present cohort 5 (27.7%) children suffered graft failure. As we previously reported 29 all of them shared a GSTT1 ‐null genotype and graft failure appeared to be the result of GSTT1 mismatch between donors who were GSTT1 ‐positive and recipients who were GSTT1 ‐null.…”

Non-Jewish Israeli IBD Patients Have Significantly Higher Glutathione S-Transferase GSTT1-Null Frequency

“…Several GST polymorphisms have been associated with increased risk of developing autoimmune diseases, e.g., GSTM1-null and rheumatoid arthritis [25]. Antibodies against GSTT1 have been identified in the immune response in patients with the GSTT1-null genotype [26,27]. These autoantibodies were found to be more prevalent in patients with IBD and primary sclerosing cholangitis [28].…”

Gene expression profiles for predicting antibody‑mediated kidney allograft rejection: Analysis of GEO datasets

“…The dominant negative mutant or RNA-mediated interference of TRIP6 reportedly inhibits nuclear factor-κB activation by TNF, IL-1, Toll-like receptor 2 or Nucleotide-binding oligomerization domain-containing protein 1 (41). detection of anti-GSTT1 antibodies in a recipient with a GSTT1-null genotype prior to transplantation was reported to be predictive of graft rejection in the event of a GSTT1-positive donor (42).…”