Glutathione S-transferase M1, T1 and P1 gene polymorphisms and the risk of developing type 2 diabetes mellitus in Egyptian diabetic patients with and without diabetic vascular complications

Zaki, Moyassar Ahmad; Moghazy, Thanaa Fathy; Eldeeb, Mona Kamal; Mohamed, Amira Hussein; Mohamed, Noha Arafa Ahmed

doi:10.1016/j.ajme.2014.03.003

Cited by 32 publications

(36 citation statements)

References 43 publications

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“…The detailed characteristics of the studies included in this meta-analysis are shown in TABLE 1. There were 6 studies with 481 DN cases and 558 controls concerning the GSTT1 polymorphism, 17,18,[20][21][22]24 8 studies with 678 DN cases and 742 controls concerning the GSTM1 polymorphism, [16][17][18][20][21][22][23][24] and 5 studies (4 publications) with 475 DN cases and 525 controls concerning the GSTP1 polymorphism. 18,19,21,22 The frequencies of homozygous deletion of both GSTM1 and GSTT1 genes were reported only in 2 studies.…”

Section: Results Characteristics Of Studiesmentioning

confidence: 99%

“…Finally, a total of 9 publications (10 studies) were included, involving 874 cases (125 Caucasian, 731 Asians, and 18 Egyptians) and 966 controls (197 Caucasians, 760 Asians, and 9 Egyptians). [16][17][18][19][20][21][22][23][24] Sample sizes ranged between 27 22 and 361. 18 Type 1 diabetes was reported for 124 patients, type 2 diabetes-for 1716.…”

Section: Results Characteristics Of Studiesmentioning

confidence: 99%

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Effects of genetic polymorphisms of glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) on the risk of diabetic nephropathy: a meta-analysis

Orlewski¹,

Orlewska²

2015

Polish Archives of Internal Medicine

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Section: Results Characteristics Of Studiesmentioning

confidence: 99%

Section: Results Characteristics Of Studiesmentioning

confidence: 99%

Effects of genetic polymorphisms of glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) on the risk of diabetic nephropathy: a meta-analysis

Orlewski¹,

Orlewska²

2015

Polish Archives of Internal Medicine

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“…Our results were in accordance with data obtained from studies with statistically varied parameters. 15,16,20,33 For example, Stoian and colleagues (2015) reported no significant association between the GSTM1 and GSTT1 null genotypes and the development of type 2 diabetes mellitus (T2DM) in a Romanian patient population compared with a healthy control group (P = .96 for GSTM1; P = .21 for GSTT1). 23 Porojan and colleagues (2015) likewise found no increased frequency of the GSTM1 and GSTT1 null genotypes in the T2DM group compared with healthy controls (for GSTM1, OR = 1.44, CI = 0.85-2.45; P = .171; for GSTT1, OR = 0.85, CI = 0.44-1.67; P = .647).…”

Section: Discussionmentioning

confidence: 99%

“…10,14 It has been demonstrated that polymorphisms in the GST gene may impair the capacity to defend against oxidative stress and lead to the development of diabetes mellitus. 15,16 Three of the GST genes-GSTT1, GSTM1, and GSTP1-are functional polymorphisms that lead directly to changes in the quantity or activity of their encoded enzymes in the general population. 17,18 GSTT1 and GSTM1 are the most common polymorphisms of GST enzymes having major ethnic differences in human populations, and they have been studied the most extensively.…”

Section: Introductionmentioning

confidence: 99%

Glutathione S-Transferase Gene Polymorphisms and the Development of New-Onset Diabetes After Liver Transplant

Musavi

Moasser²,

Zareei³

et al. 2019

Exp Clin Transplant

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Objectives: The association between the glutathione Stransferase polymorphisms and the development of new-onset diabetes mellitus after liver transplant was studied. Materials and Methods: Peripheral blood samples were collected from 106 liver transplant patients divided into 2 groups: 52 with new-onset diabetes mellitus and 54 without new-onset diabetes mellitus; 169 healthy individuals with no clinical evidence of diabetes mellitus were selected as a control group. The multiplex polymerase chain reaction technique was used for genotyping GSTM1 and GSTT1 genes, using the cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) gene as an internal control. The genotype of GSTP1 was determined using the restriction fragment length polymorphism-polymerase chain reaction technique. Results: The frequency of both GSTM1 null and GSTT1 null genotypes was not significantly different in liver transplant patients with new-onset diabetes mellitus compared with the control group (P = .11 for GSTM1; P = .71 for GSTT1). Also, there was no statistically significant association between the frequency of the GSTP1 genotypes in the liver transplant patients with new-onset diabetes mellitus compared with controls. Neither GSTM1 nor GSTT1 null genotypes were associated with the risk of developing new-onset diabetes mellitus (P = .22 for GSTM1; P = .56 for GSTT1). However, the frequency of the heterozygous mutation (AG) in the A313G GSTP1 polymorphism in patients with new-onset diabetes mellitus was significantly higher than in patients without new-onset diabetes mellitus (55.8% vs 7.4%; P = .00). Thus, the risk of developing new-onset diabetes mellitus was significantly higher in patients presenting with heterozygous GSTP1 genotypes (odds ratio = 15.76; 95% confidence interval = 4.53-60.28; P = .00). Conclusions: The GSTP1 AG genotype was associated with an increased susceptibility to the development of new-onset diabetes mellitus after liver transplant.

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“…Consequently, the cell becomes more susceptible to mutation and damage from exposure to electrophiles and ROS [50]. Despite the significance noted in the G allele in the GSTP1 gene polymorphism among diabetic cases [51,52], two studies failed to demonstrate any significant association between the GSTP1 polymorphism and DR in T2DM patients [46,50].…”

Section: Glutathione S-transferases (Gsts)mentioning

confidence: 99%

Oxidative Stress Biomarkers for Diabetic Retinopathy and Medical Management Affecting Oxidative Stress

Cilenšek¹,

Ramuš²,

Petrovič³

et al. 2016

Role of Biomarkers in Medicine

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Changes in dietary habits and lifestyles associated with rapid economic growth have dramatically increased the incidence of diabetes and related vascular complications. Diabetic retinopathy (DR), a microvascular complication of diabetes, is associated with both environmental and genetic factors. Several metabolic abnormalities are implicated in its pathogenesis; however, the exact mechanism remains to be determined. Among them, oxidative stress is expected to play an important role.Environmental, genetic, and epigenetic factors affecting the oxidative stress responsible for DR are reviewed in this paper. The knowledge about genetic biomarkers of DR is quite extensive, whereas the awareness about epigenetics and epigenetic markers is only beginning to be understood.Modulation of epigenetic changes by pharmaceutical means may provide a potential strategy to retard the progression of DR. In addition to the intense medical management, these strategies include dietary measures (antioxidants) and the introduction of epigenetic drugs, such as inhibitors of DNA methylation and histone demethylases.

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Glutathione S-transferase M1, T1 and P1 gene polymorphisms and the risk of developing type 2 diabetes mellitus in Egyptian diabetic patients with and without diabetic vascular complications

Cited by 32 publications

References 43 publications

Effects of genetic polymorphisms of glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) on the risk of diabetic nephropathy: a meta-analysis

Effects of genetic polymorphisms of glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) on the risk of diabetic nephropathy: a meta-analysis

Glutathione S-Transferase Gene Polymorphisms and the Development of New-Onset Diabetes After Liver Transplant

Oxidative Stress Biomarkers for Diabetic Retinopathy and Medical Management Affecting Oxidative Stress

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