Glutathione S-transferase M1 null genotype related to poor prognosis of colorectal cancer

Yan, Shushan; Wang, Zengfang; Wang, Zengyan; Duan, Qiangde; Wang, Xiaochen; Li, Jun; Sun, Beicheng

doi:10.1007/s13277-015-4676-4

Cited by 4 publications

(7 citation statements)

References 40 publications

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“…It is a multifactorial disease involving factors of genetics, environmental, and lifestyle. Accumulated evidence has documented several risk factors associated with the development of CRC, including physical inactivity, alcohol, smoking, and red and processed meat consumption . Additionally, some kinds of diseases have been demonstrated to be related to increased risk of CRC, such as type 2 diabetes mellitus, obesity, and inflammatory bowel diseases .…”

Section: Introductionmentioning

confidence: 99%

“…Accumulated evidence has documented several risk factors associated with the development of CRC, including physical inactivity, alcohol, smoking, and red and processed meat consumption. 2,3 Additionally, some kinds of diseases have been demonstrated to be related to increased risk of CRC, such as type 2 diabetes mellitus, obesity, and inflammatory bowel diseases. [4][5][6] Increasing number of studies have implicated that non-coding RNAs play critical roles in the initiation and progression of CRC, many of which may even affect the prognosis of patients.…”

Section: Introductionmentioning

confidence: 99%

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Exosomal miR‐6803‐5p as potential diagnostic and prognostic marker in colorectal cancer

Yan

Jiang

Liang

et al. 2018

J of Cellular Biochemistry

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Accumulating data have suggested exosome-delivered microRNAs (miRNAs) play critical role in carcinogenesis and cancer progression. However, little is known about the influence of exosomal miR-6803-5p on the development and prognosis of colorectal cancer (CRC). Levels of serum exosomal miR-6803-5p were determined by microarray analysis and verified by quantitative real-time PCR (qRT-PCR). Outcomes of overall survival (OS) and disease-free survival (DFS) of CRC patients were estimated by Kaplan-Meier analysis. We used cox regression analysis to investigate the association between exosomes-encapsulated miR-6803-5p and the clinicopathological factors of CRC patients. The exosomal miR-6803-5p was significantly increased in serum samples from patients with CRC in contrast to healthy controls. Significantly higher levels of serum exosomal miR-6803-5p were observed in CRC patients at later TNM stage or with lymph node metastasis as well as liver metastasis. Patients with elevated levels of serum exosomal miR-6803-5p had much poorer OS and DFS. Cox regression analysis revealed high levels of exosomal miR-6803-5p was associated with poor prognosis in CRC independent of other confounding factors. Thus, exosomal miR-6803-5p is a potential diagnostic and prognostic biomarker for patients with CRC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exosomal miR‐6803‐5p as potential diagnostic and prognostic marker in colorectal cancer

Yan

Jiang

Liang

et al. 2018

J of Cellular Biochemistry

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“…Many studies have shown the evidence that alcohol, smoking, lifestyle, and genetic predisposition are associated with increased risk of CRC. [11][12][13] Despite great progress in the early diagnosis and treatment of this deadly disease, searching for more sensitive and specific biomarkers for CRC is urgent for improving the quality of life and patients' prognosis. Recently, circulating exosome-encapsulated miRNAs have been demonstrated to play crucial roles in colorectal carcinogenesis and even the prognosis of patients with CRC.…”

Section: Introductionmentioning

confidence: 99%

“…The etiology of this disease is not fully understood up to date. Many studies have shown the evidence that alcohol, smoking, lifestyle, and genetic predisposition are associated with increased risk of CRC . Despite great progress in the early diagnosis and treatment of this deadly disease, searching for more sensitive and specific biomarkers for CRC is urgent for improving the quality of life and patients’ prognosis.…”

Section: Introductionmentioning

confidence: 99%

“…It has been well established that many factors influence the prognosis of CRC, for instance, age, sex, status of tumor differentiation, tumor size, location, hyperuricemia, and single nucleotide polymorphisms (SNPs) of susceptible genes. 12,20,21 During the past few years, miRNAs have shown significant promise as prognostic markers in CRC because of their unique expression profile in different kinds of diseases and the critical regulatory effects in carcinogenesis, tumor progression, invasion, angiogenesis, and metastases. 22,23 MiRNAs may also serve as potential therapeutic targets themselves in CRC, because they have been demonstrated to participate in biological processes involved in tumor progression.…”

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confidence: 99%

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Downregulation of exosome‐encapsulated miR‐548c‐5p is associated with poor prognosis in colorectal cancer

Peng

Yan

2018

J of Cellular Biochemistry

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The role of circulating exosomal microRNAs (miRNAs) in colorectal cancer (CRC) has drawn more and more attention during the past few years. Previously, we have identified several specific miRNAs in serum exosomes as potential CRC biomarkers. However, little is known about the association between exosome-encapsulated miR-548c-5p and outcomes of patients with CRC. In the current study, the expression of serum exosomal miR-548c-5p was investigated by quantitative real-time polymerase chain reaction. Its correlation with CRC prognosis was estimated by Kaplan-Meier survival and log-rank tests. Cox regression analysis based on uni- and multivariate analyses was performed to estimate the relationship of exosome-encapsulated miR-548c-5p with the clinicopathological factors of patients with CRC. Reduced levels of serum exosomal miR-548c-5p were more significant in CRC patients with liver metastasis and at later TNM stage (III/IV tumor stages). Serum exosomal miR-548c-5p could inhibit the proliferation of CRC cells, while the precise molecular mechanisms warranted further elucidation. In addition, decreased levels of serum exosomal miR-548c-5p were independently associated with shorter overall survival in CRC adjusted by age, sex, tumor grade vascular infiltration, TNM stage (III/IV tumor stages) and metastasis (hazard ratio = 3.40, 95% confidence interval 1.02-11.27; P = 0.046). The downregulation of exosomal miR-548c-5p in serum predicts poor prognosis in patients with CRC. Exosomal miR-548c-5p may be a critical biomarker for CRC diagnosis and prognosis.

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Integrated computer analysis and a self-built Chinese cohort study identified GSTM2 as one survival-relevant gene in human colon cancer potentially regulating immune microenvironment

Zhang

Shi

Niu³

et al. 2022

Front. Oncol.

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According to a recent report by GLOBOCAN, colorectal cancer is the third most common and second most deadly cancer in 2020. In our previous proteomic study, we found that the expression of GSTM2 in colon tissues was significantly lower than that in para-cancer tissues, and its lower expression was associated with reduced overall survival rate of patients, suggesting that this gene might play a role in the occurrence of colon cancer. As a member of the detoxifying enzyme family, GSTM2 is likely to play an important role in the initiation of tumors. Whereas, the functions of GSTM2 in colon cancer are barely known. In this study, using the RNA-Seq datasets of colon cancer patients from public database (ntumor = 457, nnormal = 41), we confirmed the reduced expression of GSTM2 and its prognostic value in colon cancer. Furthermore, we used our own Chinese cohort (ntumor = 100, nnormal = 72) verified the lower GSTM2 expression in colon cancer, and also its effects on patient prognosis. Subsequently, we uncovered two potential reasons for the lower expression of GSTM2 in colon cancer tissues, including the deep deletion of GSTM2 on genome, and the up-regulation of RAD21 or SP1. Moreover, we disclosed that GSTM2 might be involved in several immune-related pathways in colon cancer, such as chemokine signaling and leukocyte transendothelial migration. Finally, we revealed that the GSTM2 expression was closely related to the immune-related scores of colon cancer and the infiltration ratios of various immune cells, suggesting that GSTM2 might regulate the development of colon cancer by modulating immune microenvironment. In conclusion, we uncovered the prognostic value of GSTM2 based on the public data and our own data, revealed its potential regulatory role in tumor immune microenvironment, and disclosed the probable reasons for its lower expression in colon cancer. The findings of our study provide a potential prognostic biomarker and drug target for clinical diagnosis and treatment of colon cancer.

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Glutathione S-transferase M1 null genotype related to poor prognosis of colorectal cancer

Cited by 4 publications

References 40 publications

Exosomal miR‐6803‐5p as potential diagnostic and prognostic marker in colorectal cancer

Exosomal miR‐6803‐5p as potential diagnostic and prognostic marker in colorectal cancer

Downregulation of exosome‐encapsulated miR‐548c‐5p is associated with poor prognosis in colorectal cancer

Integrated computer analysis and a self-built Chinese cohort study identified GSTM2 as one survival-relevant gene in human colon cancer potentially regulating immune microenvironment

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