Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk

Zheng, Tonzhang; Holford, Theodore R.; Zahm, Shelia Hoar; Owens, Pamela L; Boyle, Peter; Zhang, Y; Zhang, B; Wise, John Pierce; Stephenson, Lisa; Ali‐Osman, Francis

doi:10.1038/sj.bjc.6600708

Cited by 58 publications

(50 citation statements)

References 21 publications

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“…10-5.90). An effect of GSTT1 null genotype on breast cancer risk is in agreement with three previous studies [24][25][26] but such risk was not observed in eight other studies [27][28][29][30][31][32][33][34]. Our observation may be a chance finding, also in view of the absence of an association for current smokers, even for those who smoke more than 20 cigarettes per day.…”

Section: Discussionsupporting

confidence: 92%

Cumulative genetic defects in carcinogen metabolism may increase breast cancer risk (The Netherlands)

Hel

Bueno-de-Mesquita

Gils

et al. 2005

Cancer Causes Control

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Variants in the metabolic genes NAT1, NAT2, GSTM1 or GSTT1, may cause differences in individual detoxifying capacity of possible carcinogens. We examined the cumulative effect of putative at risk genotypes on breast cancer risk and we examined the extent to which these polymorphisms modify the association between smoking and breast cancer. A case cohort study was conducted in the DOM cohort with 676 breast cancer cases and a random sample of 669 individuals. No effect of the NAT1, NAT2 or GSTM1 genotypes on breast cancer risk was observed. However, women with GSTT1 null genotype had a 30% increased breast cancer risk compared to women with GSTT1 present (RR = 1.30 (95% confidence interval (CI) 1.04-1.64)). Smoking did not influence breast cancer risk nor did genetic variations in NAT1, NAT2 or GSTM1 in combination with smoking. Compared to women who never smoked with GSTT1 present, women with GSTT1 null genotype and who formerly smoked showed an increased breast cancer risk (RR = 2.55 (95% CI 1.10-5.90)), but current smokers who smoked 20 cigarettes or more per day did not (RR = 1.06 (95% CI 0.51-2.18)). Increasing numbers of putative at risk genotypes increased breast cancer risk in a dose dependent manner (p for trend 0.01). The risk was more than doubled in women with all four risk genotypes, RR = 2.45 (95% CI 1.24-4.86), compared to women with zero putative at risk genotypes. In conclusion, the results of this study suggest that presence of three or more putative at risk genotypes increases breast cancer risk.Abbreviations: BMI -body mass index; CI -confidence interval; DOM -diagnostic study on breast cancer; GSTglutathione S-transferase; IRR -incidence rate ratio; NAT -N-acetyltransferase

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Section: Discussionsupporting

confidence: 92%

Cumulative genetic defects in carcinogen metabolism may increase breast cancer risk (The Netherlands)

Hel

Bueno-de-Mesquita

Gils

et al. 2005

Cancer Causes Control

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“…Out of the 161 abstracts retrieved through the search criteria, 94 were irrelevant, nine articles [35][36][37][38][39][40][41][42][43] were excluded because they were conducted on overlapping populations with other eligible studies [6,8,20,25,30,44,45] (these excluded articles represent smaller studies performed on subsets of larger eligible studies), five studies [46][47][48][49][50] were excluded given that they have not included controls in their study design, two articles [4,51] were reviews/meta-analyses, and three studies [52][53][54] were excluded due to other reasons (two of them [52,53] was excluded due to reporting reasons, i.e. no reporting of the relevant genotype frequencies, whereas the other [54] was excluded for examining the association between GSTA1 polymorphism and survival after breast cancer treatment At the overall analysis, the null GSTT1 genotype was associated with elevated breast cancer risk (pooled OR=1.114, 95%CI: 1.035-1.199, random effects).…”

Section: Resultsmentioning

confidence: 99%

“…In the present meta-analysis, such subanalyses have not been presented after carefully taking into account that solely ten [6,9,15,28,44,58,65,67,69,70] out of 41 studies on GSTT1 and nine [15, 28-32, 65, 67, 70] out of 30 studies on GSTP1 status have presented subanalyses on pre-and postmenopausal women. Indeed, the power of the above subsets of studies was so limited that the main associations were blurred (data not shown); as a result, proceeding to subanalyses on pre-and postmenopausal subjects did not seem of particular value.…”

Section: Discussionmentioning

confidence: 99%

GSTT1 and GSTP1 polymorphisms and breast cancer risk: a meta-analysis

Sergentanis

Economopoulos

2009

Breast Cancer Res Treat

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Cytosolic glutathione S-transferase (GST) comprises multiple isoenzymes; studies have principally examined mu-1 (GSTM1: null/present), theta-1 (GSTT1: null/present) and pi-1 (GSTP1 Ile105Val) gene polymorphisms concerning breast cancer risk. Regarding GSTT1 and GSTP1 polymorphisms, studies remain controversial and no recent meta-analysis has appeared. This meta-analysis aims to examine whether GSTT1 and GSTP1 polymorphisms are associated with breast cancer risk. Separate analyses were performed on Chinese and non-Chinese populations, in an attempt to investigate race-specific effects. Eligible articles were identified by a search of MEDLINE bibliographical database for the period up to August 2009. Regarding GSTT1 null/present genotype, 41 case-control studies were eligible (16,589 breast cancer cases and 19,995 controls); 30 case-control studies were eligible for GSTP1 Ile105Val (16,908 cases and 20,016 controls). Pooled odds ratios (OR) were appropriately derived from fixed-effects or random-effects models. At the overall analysis, the null GSTT1 genotype was associated with elevated breast cancer risk (pooled OR=1.114, 95%CI: 1.035-1.199, random effects). However, the association seemed confined to non-Chinese populations (33 studies, pooled OR=1.128, 95%CI: 1.042-1.221, random effects), given that the association was not significant in the subset of Chinese studies (eight studies, pooled OR=1.061, 95%CI: 0.875-1.286, random effects). Regarding GSTP1 Ile105Val, no statistically significant associations were detected in non-Chinese populations (25 studies). On the other hand, the GG genotype was associated with increased breast cancer risk in Chinese populations (five studies, pooled OR=1.297, 95%CI: 1.023-1.645, fixed effects); accordingly, the recessive model yielded statistically significant results (pooled OR=1.273, 95%CI: 1.006-1.610, fixed effects). In conclusion, polymorphisms of both 3 GSTT1 and GSTP1 genes seem associated with elevated breast cancer risk in a racespecific manner. Given the small number of Chinese studies, the finding on GSTP1 Ile105Val merits further investigation.

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“…The frequency of individuals who do not express the enzyme is higher in Asians (60%) and Africans (40%) than in Caucasoids (20%). 21,22 The polymorphisms of the GSTM1 and GSTT1 genes involved may result in differences in the enzymatic activity, possibly favoring mechanisms that increase the susceptibility to cancer. Studies relating these polymorphisms of deletion with the occurrence of head and neck carcinoma diverge between themselves: some demonstrate the association of these neoplasias with the null genotype of GSTM1, 7,21,[23][24][25] while others do not.…”

Section: Original Article Introductionmentioning

confidence: 99%

“…21,22 The polymorphisms of the GSTM1 and GSTT1 genes involved may result in differences in the enzymatic activity, possibly favoring mechanisms that increase the susceptibility to cancer. Studies relating these polymorphisms of deletion with the occurrence of head and neck carcinoma diverge between themselves: some demonstrate the association of these neoplasias with the null genotype of GSTM1, 7,21,[23][24][25] while others do not. [26][27][28][29][30] The same occurs with the null genotype of GSTT1, showing an association with the disease 7,23,25 or not.…”

Section: Original Article Introductionmentioning

confidence: 99%

Análise dos genes GSTM1 e GSTT1 em pacientes com câncer de cabeça e pescoço

Leme¹,

Raposo²,

Ruiz³

et al. 2010

Rev. Assoc. Med. Bras.

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Objective. To establish the clinical and demographic profile and identify risk factors among patients with head and neck cancer, relating them to the polymorphism of GSTT1 and GSTM1. MethOds. One hundred patients with head and neck cancer and 100 control group individuals without history of neoplasm were analyzed. The molecular analysis was made by multiplex polymerase chain reaction. For statistical analysis, data were tabulated and compared by the Fisher's exact test, the Chi-square test and multiple logistic regression were also used.Results. There was prevalence of smokers (OR = 5.32, CI 95% CI = 2.04-13.86 p = 0.0006), alcohol drinkers (OR = 5.04, CI 95% = 2.19-11.59 p = 0.0001) in head and neck cancer patients. The GSTT1 null genotype was found in 47% of the patient and 41% of the control group (OR = 0.67; CI 95%= 0.34-1.35; p = 0.2648). Likewise, the GSTM1 null genotype was found in 66% of the patient and 75% of the control group (OR = 2.25; CI 95%= 1.05 -4.84; p = 0.0368). The combined GSTT1 and GSTM1 gene null genotype shown association between GSTM1*0/GSTT1 and occurrence of head and neck carcinoma (OR = 7.64; CI 95%= 1.72-34.04; p = 0.0076). Analysis of clinical-pathological features showed association between GSTT1 null genotype and larynx, the inverse relation between this genotype and pharynx. cOnclusiOn. In our study it was possible to establish an association between the nullity of GSTM1 genotype and that of combined GSTT1/GSTM1*O ([]/ [-] genotypes and head and neck cancer. gstM1 and gstt1 genes analysis in head and neck canceR patients cássia veRidiana dOuRadO leMe 1 , luis séRgiO RapOsO 2 , MaRiangela tORReglOsa Ruiz 3 , jOice MatOs biselli 4 , ana lívia silva galbiatti 5 , jOsé victOR Maniglia 6 , éRika cRistina pavaRinO-beRtelli 7 , eny MaRia gOlOni-beRtOllO 8*

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Glutathione S-transferase M1 and T1 genetic polymorphisms, alcohol consumption and breast cancer risk

Cited by 58 publications

References 21 publications

Cumulative genetic defects in carcinogen metabolism may increase breast cancer risk (The Netherlands)

Cumulative genetic defects in carcinogen metabolism may increase breast cancer risk (The Netherlands)

GSTT1 and GSTP1 polymorphisms and breast cancer risk: a meta-analysis

Análise dos genes GSTM1 e GSTT1 em pacientes com câncer de cabeça e pescoço

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