Glutathione-responsive self-delivery nanoparticles assembled by curcumin dimer for enhanced intracellular drug delivery

Zhang, Huabing; Zhang, Yubin; Chen, Yilin; Zhang, Ying; Wang, Yange; Zhang, Yinying; Song, Liang; Jiang, Beili; Su, Guanghao; Yang, Li; Hou, Zhenqing

doi:10.1016/j.ijpharm.2018.07.061

Cited by 33 publications

(12 citation statements)

References 24 publications

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“…This demonstrated that the green fluorescence emitted by free curcumin inside the cells was very weak, which indicated that most of the free curcumin was not taken up by the macrophage cell line, RAW 264.7. As NPs might have promising potential for highly efficient intracellular drug delivery [ 41 , 42 ], it was observed that curcumin-loaded CS-BSA NPs showed increased fluorescence intensity when compared with cells treated with free curcumin, suggesting that CS-BSA NPs could improve the cellular uptake of curcumin. Herein, this observation indicated that CS-BSA NPs could effectively promote drug accumulation within the cells.…”

Section: Resultsmentioning

confidence: 99%

Curcumin-loaded chitosan–bovine serum albumin nanoparticles potentially enhanced Aβ 42 phagocytosis and modulated macrophage polarization in Alzheimer’s disease

et al. 2018

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Alzheimer’s disease (AD) is the most common neurodegenerative disorder in the elderly population. In the treatment of AD, some obstacles, including drug penetration difficulty through the blood–brain barrier (BBB), inadequate clearance of the Aβ peptide, and the massive release of inflammatory factors, must be urgently overcome. To solve these problems, we developed special and novel nanoparticles (NPs) made of chitosan (CS) and bovine serum albumin (BSA) to enhance the penetration of drugs through the BBB. Curcumin as a potent anti-inflammatory agent was used to increase the phagocytosis of the Aβ peptide. The results demonstrated that curcumin-loaded CS-BSA NPs effectively increased drug penetration through the BBB, promoted the activation of microglia, and further accelerated the phagocytosis of the Aβ peptide. Furthermore, curcumin-loaded CS-BSA NPs inhibited the TLR4-MAPK/NF-κB signaling pathway and further downregulated M1 macrophage polarization. This study suggested that curcumin-loaded CS-BSA NPs hold the potential to enhance Aβ 42 phagocytosis through modulating macrophage polarization in AD.

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Section: Resultsmentioning

confidence: 99%

Curcumin-loaded chitosan–bovine serum albumin nanoparticles potentially enhanced Aβ 42 phagocytosis and modulated macrophage polarization in Alzheimer’s disease

et al. 2018

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“…These nanoparticles had the characteristics of uniform particle size, high blood stability, and fast drug release in tumor cells and had higher tumor inhibition rate in vivo compared with free DTX, as shown in Figure 5B. Zhang et al [75] synthesized a kind of CUR-S-CUR prodrug by coupling two CUR molecules with mono thioether bond for GSH responsive drug delivery, as shown in Figure 5C. These CUR-S-CUR NPs exhibited good colloid stability, more efficient cellular uptake, and intracellular/nuclear drug delivery compared to free CUR.…”

Section: Chemical Bonds That React With Gshmentioning

confidence: 98%

Nano-Drug Design Based on the Physiological Properties of Glutathione

2021

Molecules

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Glutathione (GSH) is involved in and regulates important physiological functions of the body as an essential antioxidant. GSH plays an important role in anti-oxidation, detoxification, anti-aging, enhancing immunity and anti-tumor activity. Herein, based on the physiological properties of GSH in different diseases, mainly including the strong reducibility of GSH, high GSH content in tumor cells, and the NADPH depletion when GSSH is reduced to GSH, we extensively report the design principles, effect, and potential problems of various nano-drugs in diabetes, cancer, nervous system diseases, fluorescent probes, imaging, and food. These studies make full use of the physiological and pathological value of GSH and develop excellent design methods of nano-drugs related to GSH, which shows important scientific significance and prominent application value for the related diseases research that GSH participates in or responds to.

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“…For instance, drug delivery systems based on NP have attracted much attention. CUR can be encapsulated inside NPs to promote its water solubility, biocompatibility, and protection from breaking down, and enhance CUR accumulation in cancerous regions because of increased permeability and retention impact [47,48]. In the investigation of Xu et al, CUR was encapsulated with niosome and its therapeutic effects against OCa cells were assessed [49].…”

Section: Use Of Curcumin and Its Nanoformulations Against Ovarian Cancermentioning

confidence: 99%

The Therapeutic Potential of Common Herbal and Nano-Based Herbal Formulations against Ovarian Cancer: New Insight into the Current Evidence

et al. 2021

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Ovarian cancer (OCa) is characterized as one of the common reasons for cancer-associated death in women globally. This gynecological disorder is chiefly named the “silent killer” due to lacking an association between disease manifestations in the early stages and OCa. Because of the disease recurrence and resistance to common therapies, discovering an effective therapeutic way against the disease is a challenge. According to documents, some popular herbal formulations, such as curcumin, quercetin, and resveratrol, can serve as an anti-cancer agent through different mechanisms. However, these herbal products may be accompanied by some pharmacological limitations, such as poor bioavailability, instability, and weak water solubility. On the contrary, using nano-based material, e.g., nanoparticles (NPs), micelles, liposomes, can significantly solve these limitations. Therefore, in the present study, we will summarize the anti-cancer aspects of these herbal and-nano-based herbal formulations with a focus on their mechanisms against OCa.

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Glutathione-responsive self-delivery nanoparticles assembled by curcumin dimer for enhanced intracellular drug delivery

Cited by 33 publications

References 24 publications

Curcumin-loaded chitosan–bovine serum albumin nanoparticles potentially enhanced Aβ 42 phagocytosis and modulated macrophage polarization in Alzheimer’s disease

Curcumin-loaded chitosan–bovine serum albumin nanoparticles potentially enhanced Aβ 42 phagocytosis and modulated macrophage polarization in Alzheimer’s disease

Nano-Drug Design Based on the Physiological Properties of Glutathione

The Therapeutic Potential of Common Herbal and Nano-Based Herbal Formulations against Ovarian Cancer: New Insight into the Current Evidence

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