Glutathione-responsive multifunctional nanoparticles based on mannose-modified pillar[5]arene for targeted antibiotic delivery against intracellular methicillin-resistant <i>S. aureus</i>

Peng, Haibo; Xie, Beibei; Cen, Xianfeng; Dai, Jiaojiao; Dai, Yuanwei; Yang, Xiaohong; He, Yun

doi:10.1039/d1qm01459e

Cited by 14 publications

(11 citation statements)

References 51 publications

(59 reference statements)

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“…Yang, He, and co-authors reported P5A-based nanoparticles for targeted antibiotic delivery for treating methicillin-resistant S. aureus [ 75 ]. To do that, mannose-modified pillar[5]arene was assembled for the preparation of a glutathione (GSH)-responsive multifunctional antibiotic delivery system (“ WP5A*G ”) based on the host–guest interaction between P5A and a near-infrared (NIR) fluorescence receptor ( G ), which was successfully developed.…”

Section: Pillararene-based Antibacterial Systemsmentioning

confidence: 99%

Pillararenes as Promising Carriers for Drug Delivery

Zyryanov

Kopchuk

Коvalev

et al. 2023

IJMS

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Since their discovery in 2008 by N. Ogoshi and co-authors, pillararenes (PAs) have become popular hosts for molecular recognition and supramolecular chemistry, as well as other practical applications. The most useful property of these fascinating macrocycles is their ability to accommodate reversibly guest molecules of various kinds, including drugs or drug-like molecules, in their highly ordered rigid cavity. The last two features of pillararenes are widely used in various pillararene-based molecular devices and machines, stimuli-responsive supramolecular/host–guest systems, porous/nonporous materials, organic–inorganic hybrid systems, catalysis, and, finally, drug delivery systems. In this review, the most representative and important results on using pillararenes for drug delivery systems for the last decade are presented.

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Section: Pillararene-based Antibacterial Systemsmentioning

confidence: 99%

Pillararenes as Promising Carriers for Drug Delivery

Zyryanov

Kopchuk

Коvalev

et al. 2023

IJMS

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“…77 After this, a series of lactose, galactose, and mannose functionalized pillararenes were employed to construct various targeted drug delivery systems. [78][79][80][81][82][83][84] All these pillararenes were constructed through the copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) reaction. These targeted group modified pillararenes were then used in cancer chemotherapy, phototherapy and their synergistic therapy (Fig.…”

Section: Targeted Group Modified Pillararenesmentioning

confidence: 99%

The design strategy for pillararene based active targeted drug delivery systems

Lu,

Xia,

Huang

et al. 2023

Chem. Commun.

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“…Recently, He and coworkers employed disulfide bonds as GSH‐responsive units to construct a smart nanotheranostic (LZD‐WP5⊃G) for NIR fluorescence imaging‐guided intracellular infection treatment ( Figure A). [ 102 ] WP5⊃G could be synthesized by hydrophobic action and CH–π interactions after mannose‐modified pillar[5]arene (WP5) was mixed with a NIR fluorescence receptor (G). Due to the hydrophobic core of WP5⊃G, linezolid (LZD) could be loaded efficiently to harvest LZD‐WP5⊃G nanoagents.…”

Section: Stimuli‐activatable Turn‐on Antibacterial Theranosticsmentioning

confidence: 99%

“…Reproduced with permission. [ 102 ] Copyright 2022, Royal Society of Chemistry. B) PLNPs‐CS‐Cu 2+ theranostic nanoplatform for the persistent luminescence detection of bacterial infection and GSH depletion‐enhanced chemodynamic antibacterial activity.…”

Section: Stimuli‐activatable Turn‐on Antibacterial Theranosticsmentioning

confidence: 99%

Stimuli‐Actuated Turn‐On Theranostic Nanoplatforms for Imaging‐Guided Antibacterial Treatment

Yang,

Song,

Dong

et al. 2023

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Antibacterial theranostic nanoplatforms, which integrate diagnostic and therapeutic properties, exhibit gigantic application prospects in precision medicine. However, traditional theranostic nanoplatforms usually present an always‐on signal output, which leads to poor specificity or selectivity in the treatment of bacterial infections. To address this challenge, stimuli‐actuated turn‐on nanoplatforms are developed for simultaneous activation of diagnostic signals (e.g., fluorescent, photoacoustic, magnetic signals) and initiation of antibacterial treatment. Specifically, by combining the infection microenvironment‐responsive activation of visual signals and antibacterial activity, these theranostic nanoplatforms exert both higher accurate diagnosis rates and more effective treatment effects. In this review, the imaging and treatment strategies that are commonly used in the clinic are first briefly introduced. Next, the recent progress of stimuli‐actuated turn‐on theranostic nanoplatforms for treating bacterial infectious diseases is summarized in detail. Finally, current bottlenecks and future opportunities of antibacterial theranostic nanoplatforms are also outlined and discussed.

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Glutathione-responsive multifunctional nanoparticles based on mannose-modified pillar[5]arene for targeted antibiotic delivery against intracellular methicillin-resistant S. aureus

Abstract: MRSA can evade the immune system once they are engulfed by phagocytic host cells. This protects them against the bactericidal action of antibiotics and allows the infection to remain latent...

Cited by 14 publications

References 51 publications

Pillararenes as Promising Carriers for Drug Delivery

Pillararenes as Promising Carriers for Drug Delivery

The design strategy for pillararene based active targeted drug delivery systems

Stimuli‐Actuated Turn‐On Theranostic Nanoplatforms for Imaging‐Guided Antibacterial Treatment

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