Glutathione-responsive mesoporous silica nanocarriers for chemo–photothermal–photodynamic therapy of cancer

NIR-II responsive PEGylated MoO2 nanocrystals with LSPR for efficient photothermal and photodynamic performance enhancement

“…1 Photothermal therapy (PTT) and photodynamic therapy (PDT) are two representative methods of phototherapy, involving the transformation of light energy to generate hyperthermia or toxic reactive oxygen species (ROS) for the induction of tumor cell apoptosis, respectively. 2 Many groups have been dedicated to the synergistic therapy of PTT and PDT in one anticancer system for better therapeutic effects, by combining carbon nanomaterials, 3 mesoporous silica nanomaterials, 4 Au nanomaterials, 5 MoS 2 , 6 Prussian blue, 7 and polymer nanoparticles 8 with different types of photosensitizers, like methylene blue, 9 Chlorin e6 (Ce6), 10 phthalocyanine, 11 etc . Nevertheless, the above dual-modal phototherapeutic strategy usually demands two different excitation wavelengths, leading to a prolonged and complicated therapy process.…”

Virus‐Bionic Mesoporous Silica Nanoplatform for Malignant Tumor Inhibition via Effective Cellular Uptake and Precise Drug Delivery

“…[1][2][3] Among them, mesoporous silica based nanosystem (mSN) has become the most favorable studied subjects as the promising nanoplatform for the specific drug delivery and controlled release of small drugs. [4][5][6][7][8][9][10][11][12] They present intrinsically incomparable features, like superior biocompatibility and exceptional chemical stability, high specific surface area and porosity, versatile surface functionalization, low cost. [13,14] Specif-ically, the renowned recent studies have principally focused on the adjustment of mesopore size that achieving the various kinds of pores with unprecedented large size, approximately 25 nm.…”

“…Recently, multifarious nanovesicles have been tailored for tumor therapy, like precise intracellular delivery and molecular bioimaging [1–3] . Among them, mesoporous silica based nanosystem (mSN) has become the most favorable studied subjects as the promising nanoplatform for the specific drug delivery and controlled release of small drugs [4–12] . They present intrinsically incomparable features, like superior biocompatibility and exceptional chemical stability, high specific surface area and porosity, versatile surface functionalization, low cost [13,14] .…”