Glutathione-responsive hydrogel and molecularly imprinted polymer nanospheres: New aspect on cisplatin delivery

Loghmani, Mohammad Hassan; Shojaie, Abdollah Fallah; Hosseini, Seyyedeh Azadeh

doi:10.1016/j.jiec.2020.12.018

Cited by 9 publications

(7 citation statements)

References 37 publications

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“…This augmented surface area allows for enhanced accessibility, resulting in a greater degree of wettability. 51,52 This concludes that the release mechanism was affected by the properties of the drug (template), the MIP composition, which reflects the hydrophilicity and hydrophobicity properties of the MIP, and the interaction of drug molecules with the polymer cavity. Table 1 explains the MIP for DDS with a sustained drug release profile.…”

Section: The Mechanism Of Drug Release From Mipmentioning

confidence: 97%

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Current advances in molecularly imprinted polymers and their release mechanisms in drug delivery systems

Lawai,

Ngaini,

Farooq

et al. 2024

Polymers for Advanced Techs

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Molecularly imprinted polymer (MIP) has gained wide interest among researchers due to its unique molecular recognition of the template that is suitable as a drug carrier. Therefore, the preparation and formulation of the MIP are significant to suit the needs of the intended use. Due to its significance in drug delivery, this review aims to highlight various methods in the preparation of MIP, the composition for both controlled and stimuli‐responsive drug delivery systems, and the release mechanism of the drugs. In drug delivery systems, MIP should have a sustained release performance as well as flexibility in surface modification for targeted delivery via a range of stimuli‐responses, including external stimuli (magnetic, light) and internal stimuli (pH, temperature, redox, biological). The properties of sustained release and targeted delivery of the MIP can improve the drug's therapeutic efficacy as well as the breakthrough for the tumor targeting application.

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Section: The Mechanism Of Drug Release From Mipmentioning

confidence: 97%

“…Apart from that, smaller nanoparticles demonstrate a higher release rate due to their increased surface area‐to‐volume ratio. This augmented surface area allows for enhanced accessibility, resulting in a greater degree of wettability 51,52 …”

Section: The Mechanism Of Drug Release From Mipmentioning

confidence: 99%

Current advances in molecularly imprinted polymers and their release mechanisms in drug delivery systems

Lawai,

Ngaini,

Farooq

et al. 2024

Polymers for Advanced Techs

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show abstract

“…103 To produce new nanohydrogels as potential platforms for drug delivery, M12 and M14 were frequently considered. 74,[104][105][106][107][108][109] Wang and coworkers obtained nanohydrogels in a distillation-precipitation FRP of MAA with M12. 104 Due to the electrostatic interactions between DOX amine groups and the carboxyl groups incorporated into the nanohydrogels it was possible to load the matrix with up to 42.3 wt% DOX at physiological pH.…”

Section: Polymer Chemistry Reviewmentioning

confidence: 99%

“…Copolymerization of (2-hydroxyethyl) methacrylate ( HEMA ) and M12 via a FRP precipitation-polymerization in water in the presence of cisplatin provided hydrogels imprinted with the anticancer drug. 107 The cisplatin remained complexed with the polymer through hydrogen bonding and was reported to be more effectively released in acidic conditions than at physiological pH. As mentioned in section 2.1.2, M14 (BMCy) has also been applied for the synthesis of polymer drug delivery systems involving camptothecin (CPT).…”

Section: Monomers Containing Pendant Disulfide Functionalitymentioning

confidence: 99%

Disulfide-containing monomers in chain-growth polymerization

et al. 2023

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“…Thus, effectively enhancing the ability of MIPs to target tumor cells and improving their drug-loading ability remain an urgent unsolved problem. Recent studies of drug-loaded MIPs used anticancer drugs as template molecules to prepare MIPs for targeted therapy. , However, this inevitably leads to issues such as insufficient drug loading, early drug leakage, and inability to reach the tumor site, thereby severely limiting the therapeutic effects of the treatment. In addition, MIPs may encounter degradation difficulty, resulting in the accumulation of toxic substances in the body, which is an insurmountable barrier in developing targeted MIPs.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Imprinted Polymer Based on ZIF-8/DOX-HA for Synergistically Targeting Prostate Cancer Cells and Controlled Drug Release with Multiple Responses

Song

Shuang

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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Improving the drug loading and delivery efficiency of biodegradable nanomaterials used for targeting prostate cancer (PCa) remains a challenging task. To accomplish this task, herein, a new surface molecularly imprinted polymer (ZIF-8/DOX-HA@MIP) was designed and constructed with a hyaluronic acid (HA)-modified zeolitic imidazolate framework-8 (ZIF-8) metal–organic framework loaded with doxorubicin (DOX) as a substrate and a responsive molecularly imprinted polymer film as a shell. Owing to the large surface area of ZIF-8, DOX was successfully loaded into the ZIF-8/DOX-HA@MIP with a high drug loading efficiency (more than 88%). In vitro cell experiments have shown that the strengthened targeting ability of ZIF-8/DOX-HA@MIP to PCa cells was realized through the synergistic effect of HA and the molecularly imprinted membrane. Under the condition of simulated tumor microenvironment solution, Zn species were released and the particle size of ZIF-8/DOX-HA@MIP decreased gradually by the synergistic effect of hyaluronidase, pH, and glutathione, showing excellent biodegradability. In vivo antitumor research indicated the excellent antitumor activity and biocompatibility of ZIF-8/DOX-HA@MIP. The multifunctional ZIF-8/DOX-HA@MIP constructed herein provides a novel impetus for the development of targeted drug delivery in PCa treatment and a new strategy for treating other tumors.

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Glutathione-responsive hydrogel and molecularly imprinted polymer nanospheres: New aspect on cisplatin delivery

Cited by 9 publications

References 37 publications

Current advances in molecularly imprinted polymers and their release mechanisms in drug delivery systems

Current advances in molecularly imprinted polymers and their release mechanisms in drug delivery systems

Disulfide-containing monomers in chain-growth polymerization

Biodegradable Imprinted Polymer Based on ZIF-8/DOX-HA for Synergistically Targeting Prostate Cancer Cells and Controlled Drug Release with Multiple Responses

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