Glutathione peroxidase and selenium in sheep. II.* The relationship between glutathione peroxidase and selenium-responsive unthriftiness in Merino lambs

Paynter, DI; Anderson, J J; McDonald, J. W.

doi:10.1071/ar9790703

Cited by 21 publications

(2 citation statements)

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“…GSH-Px is now well established to be a selenoenzyme, and the determination of GSH-Px activity has been widely used to assess the selenium status of animals (GANTHER et al, 1976). Selenium deficiency has been connected with the occurrence of diseases in man (WESTERMARCK and SANDHOLM, 1977) and animals (PAYNTER et al, 1979). Since the enzyme GSH-Px utilizes GSH as its substrate, further research is desirable to define more accurately the relationship of GSH metabolism to this disease.…”

Section: Discussionmentioning

confidence: 99%

A Heritable Disorder of Collagen Tissue in Finnish Crossbred Sheep

Atroshi¹,

Henriksson²,

Lindberg³

et al. 1983

Zentralblatt für Veterinärmedizin Reihe A

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Diseases inherited as simple recessive frequently reflect simple anomalies in the structure of enzymic proteins. Many such inherited diseases of humans have now been defined in biochemical terms, but relatively few have been described adequately in domestic animals. Collagen is reported to be involved in many diseases in man (PINNELL et al., 1972) and animals (O'HARA et al., 1970). FJ~LSTAD and HELLE (1974) reported an inherited disease in Dala sheep, characterized by a defect in the normal packing of collagen molecules into fibres. The clinical diagnostic feature of a collagenous tissue dysplasia disease is considered to be fragility of the skin, leading to the formation of papyraceous scars. This disease has many clinical characteristics in common with the Ehlers-Danlos syndrome of man (PEARSE, 1964), cutaneous asthenia of dogs and mink (HEGREBERG et al., 1969), and dermatosparaxis of calves (ANSAY et al., 1968). A diesease with a similar clinical appearance has now been recognized in Finnish crossbred sheep.The purpose of this paper is to present the gross pathology, histo-and cytopathology of the skin of clinically affected animals, and some blood parameters of ewes giving normal and ewes giving defective lambs. Material and MethodsBreeding histo y of affected flocks Farm 1. The flock was established at Lohja province early in 1977 from 9 Finnsheep ewes and one ram. No defective lambs were noticed at the first lambing. In 1978, a Suffolk ram ( S ) was brought to the flock and the ewes were sired by this ram. He produced 30 daughters; again no defective lambs $ere noticed. In 1979 the ewelambs (i. e. the 30 daughters) were sired by their brother ram (M), also a progeny of ram (S). Of the progeny born three lambs were defective. The ewes involved have never produced more than one defective lamb. This is the type of situation where recessive defects might be expected to arise. Year-by-year lambing performance of ewes has left defective offspring of both sexes U. S.

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Section: Discussionmentioning

confidence: 99%

A Heritable Disorder of Collagen Tissue in Finnish Crossbred Sheep

Atroshi¹,

Henriksson²,

Lindberg³

et al. 1983

Zentralblatt für Veterinärmedizin Reihe A

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“…In Victoria, Australia, workers showed a 5.15% increase in weight gains in Merino lambs (Paynter et al, 1979) in an area not considered severely deficient in selenium, following a single, oral dose of 0.15 mg Se kg -i body weight. In a West Australian study, a 3% increase in fleece weight was recorded, following administration of a total of 26 mg Se per sheep, in four doses over a 6 month period (Gabbedy, 1971).…”

Section: Benefits To Animals From Selenium Usementioning

confidence: 98%

Risks and benefits in agricultural uses of selenium

Oldfield

1992

Environ Geochem Health

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Selenium deficiency in soils, and subsequently in crops that are grown on them, has been charted in various parts of the world. Use of carefully regulated amounts of supplemental selenium in such areas has been effective in improving productive performance of domestic food-producing animals, and some 30 years' experience has now been gained with various supplementation practices. Coincidentaliy, there have been instances reported of situations where selenium toxicity has resulted from a combination of naturally-high environmental levels, enhanced by agricultural, environmental and industrial practices, and questions have been raised as to whether continued animal supplementation may contribute to selenium toxicity. This paper examines some of the various factors involved and concludes that presently-established animal supplementation uses of selenium are small compared with other sources of the element and that they do not constitute a hazard to animals, including humans, or the environment.

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Indirect effects of soil and water on animal health

Horvath

Reid

1984

Science of The Total Environment

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Glutathione peroxidase and selenium in sheep. II.* The relationship between glutathione peroxidase and selenium-responsive unthriftiness in Merino lambs

Cited by 21 publications

References 0 publications

A Heritable Disorder of Collagen Tissue in Finnish Crossbred Sheep

A Heritable Disorder of Collagen Tissue in Finnish Crossbred Sheep

Risks and benefits in agricultural uses of selenium

Indirect effects of soil and water on animal health

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