Glutathione peroxidase 1 expression, malondialdehyde levels and histological alterations in the liver of Acrossocheilus fasciatus exposed to cadmium chloride

Liu, Guo-Di; Sheng, Zhang; Wang, Youfa; Han, Yingli; Zhou, Yang; Zhu, Junquan

doi:10.1016/j.gene.2015.12.034

Cited by 33 publications

(20 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This indicates that the terminators in the two amino acid sequences are also likely to be translated as U. MnGPx-3 and MnGPx-4 are believed to belong to the plasma GPx (GPx-3) class and phospholipid hydroperoxide GPx (GPx-4) class respectively by functional domain analysis and were named according to the established GPx nomenclature system. So far, all available GPxs have been divided into eight different classes based on sequence homology and molecular characteristics, and some are species-specific [19]. MnGPx-3 was classified as the GPx3 class and MnGPx-4 was classified as the GPx4 class on the phylogenetic tree.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular cloning, expression, and in situ hybridization analysis of MnGPx-3 and MnGPx-4 from oriental river prawn, Macrobrachium nipponense, in response to hypoxia and reoxygenation

Yang

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

Glutathione peroxidase (GPx) has been the focus of increased research because of its important role as an antioxidant and in reactive oxygen species (ROS) induced damage repair. Studies on GPxs have relevance with Macrobrachium nipponense because it has poor tolerance to hypoxia in Macrobrachium nipponense. The two subunits named as MnGPx-3 and MnGPx-4 according to the glutathione peroxidase nomenclature system. Both full-length cDNAs were cloned from the hepatopancreas. In this study, we analyzed the expression of two GPxs in Macrobrachium nipponense in response to changes in environmental oxygen. Expression levels of MnGPx-3 and MnGPx-4 indicated that both have strong responses to hypoxia. In situ hybridization showed that MnGPx-3 and MnGPx-4 were located in secretory and storage cells in hepatopancreas. These results suggest that GPx gene is expressed and released by secretory cells and released response to hypoxia. In the gill tissue, however, GPxs are located in blood cells, suggesting that they perform different functions in different tissues or organs. The results of in situ hybridization were consistent with those of quantitative Real-time PCR. This study provides a basis for understanding the oxidative stress response in M. nipponense under hypoxia.

show abstract

Section: Discussionmentioning

confidence: 99%

“…In addition to their function in mammals, GPx also has strong biocatalytic and detoxifying functions in aquatic organisms [16][17][18]. GPx-1 has been fully studied in Acrossocheilus fasciatus [19], and a GPx-4 has been reported in Penaeus monodon [20]. However, GPx has not been investigated in Macrobrachium nipponense.…”

Section: Introductionmentioning

confidence: 99%

Molecular cloning, expression, and in situ hybridization analysis of MnGPx-3 and MnGPx-4 from oriental river prawn, Macrobrachium nipponense, in response to hypoxia and reoxygenation

Yang

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Once liver damage is established, the homeostasis of the organism as a whole can be affected by interfering with some of the organ's basic functions such as the synthesis and biotransformation of molecules [29]. Therefore, liver histology is an important biomarker for evaluating the effects of xenobiotics [30]. One of the histopathological findings when analyzing the group treated with EHELf was cytoplasmic vacuolization, a fact that was also shown in the study by Gayão et al [31], who attributed this phenomenon to the possible accumulation of lipids, thus impairing liver metabolism.…”

Section: Discussionmentioning

confidence: 99%

Libidibia ferrea (jucá), a Traditional Anti-Inflammatory: A Study of Acute Toxicity in Adult and Embryos Zebrafish (Danio rerio)

et al. 2019

View full text Add to dashboard Cite

The plant species Libidibia ferrea (Mart. ex Tul.) LP Queiroz var. ferrea basionym of Caesalpinia ferrea (Mart. ex Tul.) is used in various regions of Brazil in folk medicine in the treatment of several health problems, especially in acute and chronic inflammatory processes. Most of the preparations employed are alcoholic. Therefore, this study aimed to evaluate the acute toxicity of the hydroethanolic extract of fruits of Libidibia ferrea (EHEFLf) in zebrafish, emphasizing the possible changes in the organic-cellular level of the gills, liver, kidneys, and intestine and on embryos. The result obtained by LC-M/MS from EHEFLf indicated a high concentration of possible polyhydroxylated substances. EHEFLf, at a dose of 2 g/kg orally, produced non-significant alterations of the analyzed organs. However, for embryos, the treatment with different concentrations demonstrated heart toxicity that was concentration-dependent. There is no evidence of a correlation of the observed effects with the phytochemical composition, and considering the species of animal used, it can be suggested that the oral use of L. ferrea hydroethanolic extract has an acceptable degree of safety for use as an oral medicinal product. and embryo results have shown significant affinity to the heart; however, it is perceived to be related to the concentrations used.

show abstract

“…Acrossocheilus is commonly known as monitoring and evaluators of the environmental contaminants by its sensitive to aquatic pollution (Liu et al 2016). In the natural state, Acrossocheilus is widely distributed in the the gravel sediment of rivers and streams.…”

mentioning

confidence: 99%

Characterization the mitochondrial genome of Acrossocheilus Labiatus (Cypriniformes, Acrossocheilus) and its phylogeny

Xie

Chen

Niu³

et al. 2019

Mitochondrial DNA Part B

View full text Add to dashboard Cite

show abstract

Glutathione peroxidase 1 expression, malondialdehyde levels and histological alterations in the liver of Acrossocheilus fasciatus exposed to cadmium chloride

Cited by 33 publications

References 72 publications

Molecular cloning, expression, and in situ hybridization analysis of MnGPx-3 and MnGPx-4 from oriental river prawn, Macrobrachium nipponense, in response to hypoxia and reoxygenation

Molecular cloning, expression, and in situ hybridization analysis of MnGPx-3 and MnGPx-4 from oriental river prawn, Macrobrachium nipponense, in response to hypoxia and reoxygenation

Libidibia ferrea (jucá), a Traditional Anti-Inflammatory: A Study of Acute Toxicity in Adult and Embryos Zebrafish (Danio rerio)

Characterization the mitochondrial genome of Acrossocheilus Labiatus (Cypriniformes, Acrossocheilus) and its phylogeny

Contact Info

Product

Resources

About