Glutathione Peroxidase 1 C593T Polymorphism Is Associated with Lobar Intracerebral Hemorrhage

Pera, Joanna; Słowik, Agnieszka; Dziedzic, Tomasz; Pułyk, Roman; Wloch, Dorota; Szczudlik, Andrzej

doi:10.1159/000126918

Cited by 26 publications

(19 citation statements)

References 29 publications

(28 reference statements)

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“…The study design and the details about both cohorts have been described elsewhere [27,28]. In brief, patients with primary ICH were prospectively recruited; cases with ICH due to secondary causes were excluded.…”

Section: Study Populationsmentioning

confidence: 99%

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Angiotensin-converting enzyme tag single nucleotide polymorphisms in patients with intracerebral hemorrhage

Dardiotis

Jagiełła²,

Xiromerisiou³

et al. 2011

Pharmacogenetics and Genomics

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Section: Study Populationsmentioning

confidence: 99%

“…Isolation of DNA, single nucleotide polymorphism selection, and genotyping Genomic DNA was prepared from peripheral blood samples by using standard procedures as described earlier [27,28].…”

Section: Study Populationsmentioning

confidence: 99%

Angiotensin-converting enzyme tag single nucleotide polymorphisms in patients with intracerebral hemorrhage

Dardiotis

Jagiełła²,

Xiromerisiou³

et al. 2011

Pharmacogenetics and Genomics

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“…[IQR], 3-15), whereas on discharge (22Ϯ7 days after stroke; range, 14 -43 days) in 43 survivals, the score was 4 (IQR, [1][2][3][4][5][6][7][8][9] Fibrin clot properties are presented in Table 2. Compared with nonstroke controls, after adjustment for age and fibrinogen levels, both acute stroke groups had prolonged t 50% , higher ⌬Abs max , and lower K s .…”

Section: Resultsmentioning

confidence: 99%

“…3 Hemorrhage location was defined as lobar or nonlobar. 2 Demographics and clinical data were collected using a standardized questionnaire. Risk factors were defined as previously described.…”

Section: Methodsmentioning

confidence: 99%

Fibrin Clot Properties in Acute Stroke

Pera

Undas

Topór-Mądry

et al. 2012

Stroke

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Background and Purpose-Fibrin clot formation is important in acute intracerebral hemorrhage (ICH). We investigated plasma fibrin clot characteristics in acute ICH compared with acute ischemic stroke (IS) and nonstroke conditions. Methods-In the 3 studied groups, we analyzed plasma fibrin clot phenotype and its association with clinical stroke presentation. Results-Compared with controls, in patients with acute strokes, fibrin clots presented with lower clot permeability, longer lysis time, and higher maximum clot absorbance (for all, PϽ0.001). In ICH patients compared with IS patients, only lysis time was shorter by 13% (PϽ0.001). In the ICH group, neurological deficit correlated significantly (PϽ0.05) with clot compaction, and the rate of increase in D-dimers released from clots, whereas initial hematoma volume correlated with lag phase of fibrin formation on turbidimetry and compaction (PϽ0.05). Conclusions-In both types of acute strokes, fibrin clot properties are altered: denser fibrin clots are relatively resistant to lysis. In acute ICH, fibrin clots are more susceptible to tissue plasminogen activator-mediated lysis compared with in IS, which might affect ICH pathogenesis.

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“…A polymorphism in the GPx-1 gene, resulting in a leucine (leu) at codon 198 rather than a proline (pro), is associated with increased risk of cancers of the lung, breast, bladder, and liver as well as lymphoma [reviewed by ]. In addition to cancer, allelic variants of GPx-1 have also been associated with the risk of cardiomyopathy (Lei et al, 2009), coronary heart disease (Winter et al, 2003;Tang et al, 2008), hypertension (Kato et al, 2008), autism (Ming et al, 2010), intracerebral hemorrhage (Pera et al, 2008), asthma (Solodilova et al, 2007), and metabolic syndrome (Solodilova et al, 2007). The at-risk GPx-1 leu allele encodes a protein that is less responsive to selenium as compared to the same protein with a proline at that position (Hu and Diamond, 2003;).…”

Section: Glutathione Peroxidase 1 (Gpx-1)mentioning

confidence: 99%

It takes 2 antioxidants to tango: the interaction between manganese superoxide dismutase and glutathione peroxidase-1

Ekoue¹,

Diamond²

2014

Turk J Biol

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The generation of ATP via oxidative phosphorylation provides the energy required by aerobic organisms to sustain themselves. This process is localized to the mitochondria, where electrons are passed among the components of the electron transport chain where there is an inevitability of leakage of the highly reactive oxygen species (ROS) superoxide, with it having been estimated that 1%-2% of the oxygen being used for mitochondrial respiration is converted to superoxide. With its short halflife and extreme reactivity, there is a strong potential for the superoxide radical to interact with biomolecules, resulting in oxidative damage that could have a profound effect on cellular function and survivability. As described below, eukaryotic cells have evolved defense mechanisms to protect themselves from the adverse effects of superoxide accumulation and the strategic location of manganese superoxide dismutase (MnSOD) in the mitochondria is a principle one of these. As a consequence of the dismutation of superoxide by MnSOD, the less reactive hydrogen peroxide (H 2 O 2 ) is generated, which can diffuse through the mitochondrial membrane where it can have its own host of biological consequences. The management of the appropriate levels of ROS is the domain of a host of antioxidant molecules such as glutathione and enzymes that can neutralize ROS. Oxidative stress occurs when the levels of ROS exceed the cell's abilities to maintain them at their appropriate levels. While less considered, the elimination of ROS past the ideal levels to support cellular function may also occur, and this has been referred to as reductive stress. ROS as important signaling moleculesAerobic organisms have not only evolved to take advantage of the enhanced energy production that can be achieved by the consumption of oxygen via the electron transport chain, but have also evolved to use ROS as potent signaling molecules. Fluctuations in ROS can be due to changes in environmental stimuli or intrinsic metabolic activity, and examples abound throughout phylogeny indicating the sensing of and response to one ROS, H 2 O 2 . As examples, plants use an oxidative burst that generates H 2 O 2 that serves as a diffusible signal to induce apoptosis in pathogenexposed cells while stimulating antioxidant enzymes in adjacent tissues (Levine et al., 1994), and a H 2 O 2 gradient generated at the tissue level in zebrafish mediates wound healing and leukocyte recruitment (Niethammer et al., 2009). One of the first examples of H 2 O 2 being critical for normal mammalian functions was the demonstration that the production of H 2 O 2 could stimulate platelet-Abstract: Reactive oxygen species (ROS) are generated during mitochondrial oxidative metabolism. Accumulation of ROS without an effective antioxidant response can lead to oxidative stress, resulting in macromolecular damage that is implicated in the etiology of various diseases including cancer. ROS detoxification is regulated by various antioxidant proteins, specifically manganese superoxide dismutase (MnSOD),...

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Glutathione Peroxidase 1 C593T Polymorphism Is Associated with Lobar Intracerebral Hemorrhage

Cited by 26 publications

References 29 publications

Angiotensin-converting enzyme tag single nucleotide polymorphisms in patients with intracerebral hemorrhage

Angiotensin-converting enzyme tag single nucleotide polymorphisms in patients with intracerebral hemorrhage

Fibrin Clot Properties in Acute Stroke

It takes 2 antioxidants to tango: the interaction between manganese superoxide dismutase and glutathione peroxidase-1

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