Glutathione oxidation correlates with one-lung ventilation time and PO₂/FiO₂ratio during pulmonary lobectomy

Abstract

During lung lobectomy and OLV, glutathione oxidation, and lipoperoxidation marker blood levels increase, with further increases after resuming TLV. Oxidative stress degree was directly correlated with OLV duration, and inversely correlated with arterial blood PO2/FiO2.

Quantitative trait mapping in Diversity Outbred mice identifies novel genomic regions associated with the hepatic glutathione redox system

“…The ratio of GSH/GSSG was then calculated. Another commonly reported measurement related to GSH dynamics and oxidative stress is the redox potential E h of the redox couple [ [62] , [63] , [64] , [65] , [66] , [67] ]. To calculate the redox potential (E h ) of the GSSG-GSH pair ( in each liver sample, we used the Nernst equation at 40 °C: …”

“…The exponential of GSH reflects the stoichiometry where 2 GSH are oxidized per 1 GSSG formed [ 62 ]. Tissue concentrations of GSH and GSSG (nmol/mg protein) were expressed in molar concentrations [ 66 , 67 ] using a conversion factor of 500 μL/mg of protein. The final equation used to calculate E h (mV) for the GSSG-GSH couple was: …”

Impact of Partial Stenosis of Trachea on Antioxidant System in Young Rats

“…Клітини уражених органів реагують на продукцію цитотоксичних вільних радикалів, пероксидів і підвищують експресію ферментів антиоксидантного захисту, зокрема каталази, супероксиддисмутази (СОД), глутатіонпероксидази (ГП) [10]. Це розглядається як фізіологічна реакція захисту на нейтралізацію вільних радикалів та виснаження неферментативних ланок захисту, зокрема, глутатіонової системи [11]. При цьому постопераційне відновлення вентиляції легень позначається у зменшенні рівні вільних радикалів та продуктів пероксидації [12].…”

“…For male individuals, the frequency of Fabry disease is approximately 1 in 40,000 to 1 in 117,000, while in female individuals, it is approximately 1 in 40,000. In certain isolated regions, the frequency in males has been observed as high as 1 in 3,100 [6][7][8][9][10][11][12].…”

Transcutaneous electrical acupoint stimulation improves pulmonary function by regulating oxidative stress during one-lung ventilation in patients with lung cancer undergoing thoracoscopic surgery: a randomized controlled trial

“…Moreover, the nondependent lung is reventilated and reoxygenated after the restoration of two-lung ventilation, which leads to hypoxia-reoxygenation injury similar to ischemia-reperfusion injury with an increase in malondialdehyde (MDA) levels and reactive oxygen species (ROS) production [2]. The degree of oxidative stress is directly related to OLV duration and negatively correlated with arterial blood PaO 2 /FiO 2 [3]. Protracted (> 1 h) OLV has been considered to be a potential cause of cardiovascular complications through the generation of oxidative stress [4], which also plays an essential part in the development of ALI and acute respiratory distress syndrome (ARDS) [5].…”