Glutathione-mediated regulation of nitric oxide, S-nitrosothiol and redox homeostasis confers cadmium tolerance by inducing transcription factors and stress response genes in tomato

Hasan, Kamrul; Liu, Congcong; Wang, Fanan; Ahammed, Golam Jalal; Zhou, Jie; Xu, Mingxing; Yu, Jingquan; Xia, Xiaojian

doi:10.1016/j.chemosphere.2016.07.053

Cited by 116 publications

(51 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antioxidant enzyme, SOD is assumed the main enzyme responsible for the first line of defense against oxygen-induced toxicity, due to its inhibitory effect on free radicals (Li, Li, & Randak, 2010). In this study, (Hasan et al, 2016). Exposure of Wistar rats to NiO NPs led to depletion in the GSH content in all three tissue homogenates, suggesting that excessive ROS was generated, which might have led to oxidative stress.…”

Section: Ni Biodistributionmentioning

confidence: 72%

Repeated oral dose toxicity study of nickel oxide nanoparticles in Wistar rats: a histological and biochemical perspective

Dumala

Mangalampalli

Kamal

et al. 2019

J of Applied Toxicology

View full text Add to dashboard Cite

Despite the increasing use of nickel oxide (NiO) nanoparticles (NPs), limited information is available on their toxicological effects. Health consequences of 28 days repeated oral exposure to NiO NPs have not been explored thoroughly. Hence, toxicity investigations were performed after 28‐day daily exposure in albino Wistar rats with NiO NPs following Organization for Economic Co‐operation and Development test guideline 407. Histopathology, biochemical indices including oxidative stress and biodistribution patterns were evaluated to decipher the toxicological impact of NiO NPs. NiO NP characterization by transmission electron microscopy showed an average size of 12.9 (±3.4) nm. Histological studies depicted a prominent impact on the vital organs of the rats. A dose‐dependent rise in both aminotransferase enzyme values was recorded in the homogenates of liver and kidney tissues. A significant decrease in superoxide dismutase activity and increase in catalase activity was noted. Further, a dose‐dependent decrease in reduced glutathione content was recorded in rats, which suggested generation of reactive oxygen species and oxidative stress. Increase in the malondialdehyde levels was observed with an increase in the dose substantiating the antioxidant enzyme activity profiles. Biodistribution studies indicated maximum accumulation of Ni content in liver followed by kidney. Excretion of Ni was predominantly through feces and a little through renal clearance. Our study indicated that NiO NPs adversely alter the biochemical profile of the rats and cause histological damage. Further investigations are warranted to address the mechanism by which physiological path these NiO NPs exhibit their toxic nature in in vivo.

show abstract

Section: Ni Biodistributionmentioning

confidence: 72%

Repeated oral dose toxicity study of nickel oxide nanoparticles in Wistar rats: a histological and biochemical perspective

Dumala

Mangalampalli

Kamal

et al. 2019

J of Applied Toxicology

View full text Add to dashboard Cite

show abstract

“…Specifically under conditions of metal stress, GSH is a non-enzymatic antioxidant that plays a central role in homeostasis and acts as a precursor to a metal-binding peptide [67]. Therefore, a high concentration of GSH in cells acts as a buffer system against redox imbalance [68]. On the other hand, silicon can counteract the negative impact of oxidative stress by restricting the production of ROS caused by arsenic, in addition to improving the action of various antioxidant compounds and regulating the osmotic potential of the cell [69].…”

Section: Discussionmentioning

confidence: 99%

Impact of Silicon Nanoparticles on the Antioxidant Compounds of Tomato Fruits Stressed by Arsenic

González-Moscoso

Martínez-Villegas

Cadenas‐Pliego³

et al. 2019

Foods

View full text Add to dashboard Cite

Tomato fruit is rich in antioxidant compounds such as lycopene and β-carotene. The beneficial effects of the bioactive compounds of tomato fruit have been documented as anticancer activities. The objective of this research was to determine whether arsenic (As) causes changes in the content of antioxidant compounds in tomato fruits and whether Silicon nanoparticles (SiO2 NPs) positively influence them. The effects on fruit quality and non-enzymatic antioxidant compounds were determined. The results showed that As decreased the oxide-reduction potential (ORP), while lycopene and β-carotene were increased by exposure to As at a low dose (0.2 mg L−1), and proteins and vitamin C decreased due to high doses of As in the interaction with SiO2 NPs. A dose of 250 mg L−1 of SiO2 NPs increased glutathione and hydrogen peroxide (H2O2), and phenols decreased with low doses of As and when they interacted with the NPs. As for the flavonoids, they increased with exposure to As and SiO2 NPs. The total antioxidant capacity, determined by the ABTS (2,2´-azino-bis[3-ethylbenzthiazolin-6-sulfonic acid]) test, showed an increase with the highest dose of As in the interaction with SiO2 NPs. The application of As at low doses induced a greater accumulation of bioactive compounds in tomato fruit; however, these compounds decreased in high doses as well as via interaction with SiO2 NPs, indicating that there was an oxidative burst.

show abstract

“…Recently, up to sixty H 2 O 2 -responsive TFs involved in stresses such as cold, drought, heat, high light, and pathogens, were identified [148]. On the other hand, GSH enhances tolerance to Cd stress in tomato by increasing the antioxidant system, NO and S-nitrosothiols via a redox-dependent upregulation of TFs such as the ethylene-responsive TFs ERF1, ERF2 and myeloblast 1 (MYB1), as well as other stress response genes [149]. In the case of Arabidopsis thaliana exposed to GSNO, RNAseq analysis reveals overexpression of TF groups including five members of the WRKY gene family involved in pathogen and abiotic stress responses, four members of the MYBTF family, heat stress TFs, and the transcription factor-binding TF GT-1 which binds to the cis-acting element BoxII [32].…”

Section: Role Of Ros and No In The Regulation Of Transcription Factormentioning

confidence: 99%

Assessment of Subcellular ROS and NO Metabolism in Higher Plants: Multifunctional Signaling Molecules

et al. 2019

View full text Add to dashboard Cite

Reactive oxygen species (ROS) and nitric oxide (NO) are produced in all aerobic life forms under both physiological and adverse conditions. Unregulated ROS/NO generation causes nitro-oxidative damage, which has a detrimental impact on the function of essential macromolecules. ROS/NO production is also involved in signaling processes as secondary messengers in plant cells under physiological conditions. ROS/NO generation takes place in different subcellular compartments including chloroplasts, mitochondria, peroxisomes, vacuoles, and a diverse range of plant membranes. This compartmentalization has been identified as an additional cellular strategy for regulating these molecules. This assessment of subcellular ROS/NO metabolisms includes the following processes: ROS/NO generation in different plant cell sites; ROS interactions with other signaling molecules, such as mitogen-activated protein kinases (MAPKs), phosphatase, calcium (Ca2+), and activator proteins; redox-sensitive genes regulated by the iron-responsive element/iron regulatory protein (IRE-IRP) system and iron regulatory transporter 1(IRT1); and ROS/NO crosstalk during signal transduction. All these processes highlight the complex relationship between ROS and NO metabolism which needs to be evaluated from a broad perspective.

show abstract

Glutathione-mediated regulation of nitric oxide, S-nitrosothiol and redox homeostasis confers cadmium tolerance by inducing transcription factors and stress response genes in tomato

Cited by 116 publications

References 52 publications

Repeated oral dose toxicity study of nickel oxide nanoparticles in Wistar rats: a histological and biochemical perspective

Repeated oral dose toxicity study of nickel oxide nanoparticles in Wistar rats: a histological and biochemical perspective

Impact of Silicon Nanoparticles on the Antioxidant Compounds of Tomato Fruits Stressed by Arsenic

Assessment of Subcellular ROS and NO Metabolism in Higher Plants: Multifunctional Signaling Molecules

Contact Info

Product

Resources

About