Glutathione levels in human tumors

Gamcsik, Michael P.; Kasibhatla, Mohit S.; Teeter, Stephanie D.; Colvin, O. Michael

doi:10.3109/1354750x.2012.715672

Cited by 480 publications

(414 citation statements)

References 114 publications

(259 reference statements)

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“…Glutathione (GSH) is an important intracellular antioxidant that prevent cellular component damage caused by reactive oxygen species. It has been suggested that GSH tends to be elevated in breast, ovarian, head/neck, and/or lung cancers as compared to disease‐free tissues 59. In tumor cells, high GSH level can trigger disulfide bond (—S—S—) cleavage.…”

Section: Bihlas For Controlled Releasementioning

confidence: 99%

Advancing the Pharmaceutical Potential of Bioinorganic Hybrid Lipid‐Based Assemblies

Wang

et al. 2018

Advanced Science

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Bioinspired lipid assemblies that mimic the elaborate architecture of natural membranes have fascinated researchers for a long time. These lipid assemblies have gone from being just an imperative platform for biophysical research to a pharmaceutical delivery system for biomedical applications. Despite success, these organized nanosystems are often subject to the mechanical instability and limited theranostic capability without adding any inconvenient modifications. To reach their advanced pharmaceutical potential, various bioinorganic hybrid lipid‐based assembles, which provide new opportunities to synergistically complement and improve therapeutic/diagnostic potential of existing lipid‐based nanomedicine with distinct mechanisms containing inorganic embedded surfactants, have recently been developed.

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Section: Bihlas For Controlled Releasementioning

confidence: 99%

Advancing the Pharmaceutical Potential of Bioinorganic Hybrid Lipid‐Based Assemblies

Wang

et al. 2018

Advanced Science

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“…В частности, в различных типах опухолей наблюдается повышенный уровень GSH, который является важным внутриклеточным антиоксидантным фактором, снижающим уровень АФК и участвующим в регуляции различных тиол-зависимых и АФК-зависимых сигнальных путей [4,8,9,18].…”

Section: результаты и обсуждениеunclassified

“…Данные литературы [9] свидетельствуют о том, что единой направленности изменений содержания GSH в опухолях различной гистологической структуры и различной локализации нет. При раке яичников, раке молочной железы, опухолях орофарингеальной зоны был обнаружен, как правило, более высокий уровень GSH в опухолевой ткани.…”

Section: результаты и обсуждениеunclassified

“…В наших предыдущих исследованиях также было выявлено более низкое содержание GSH в ткани аденокарциномы и перстневидно-клеточного рака желудка по сравнению с интактной тканью желудка [19]. В опухолях других локализаций разными исследователями был установлен как высокий, так и низкий уровень GSH по сравнению с перитуморальной и здоровой тканями [9].…”

Section: результаты и обсуждениеunclassified

“…Функционированию ферментативных и неферментативных антиоксидантных систем придают большое значение в регуляции процессов, поддерживающих прогрессию опухоли и развитие её резистентности к проводимому лечению [6,7]. Особая роль при этом отводится низкомолекулярному тиолу глутатиону и сопряжённой с ним ферментативной системе [8,9]. Понимание биологии редокс-процессов, лежащих в основе развития онкологической патологии, и механизмов их функционирования имеет большое значение для разработки новых эффективных противоопухолевых стратегий, основанных на воздействии на редокс-состояние опухоли и окружающих её тканей.…”

Section: Introductionunclassified

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The activity of redox-regulatory systems in the tumor and its surrounding tissues in various histological types of tumor

et al. 2016

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According to modern concepts cancer is a complex dynamic system having multiple relationships with both the immediate environment and with remote nonmalignant tissues and organs. Changes in the redox balance in them can result in disruption of the normal tissue control. Understanding of the biology of redox processes in a particular tumor and its surroundings, and of their functioning mechanisms is necessary for the development of new anti-cancer strategies based on the effects on the redox state of the tumor and surrounding tissue. Thus the aim of this work was to investigate activity of enzymatic systems influencing the redox state in the tumor tissue, peritumoral area and nonmalignant tissue (taken along the line of resection) for different histological types of tumors. The data obtained showed a similar level of reduced glutathione (GSH) in tumor tissues of gastric adenocarcinoma and vulvar squamous cell carcinoma, but its dynamics in the tissues surrounding the tumor was different. In contrast to the gastric adenocarcinoma the carcinoma of the vulva had a significant level of GSH and higher activity of glutathione dependent enzymes in the tumor tissue and its peritumoral area compared with the surrounding nonmalignant tissue. The results indicate that there are differences in the functioning of the redox regulatory systems in the tumor tissue and its surrounding tissues of various histological origin and localization, possibly due to different mechanisms involved in maintenance of the redox balance in the originally nonmalignant tissue

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Metabolomic profiling of human lung tumor tissues – nucleotide metabolism as a candidate for therapeutic interventions and biomarkers

et al. 2018

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Although metabolomics has attracted considerable attention in the field of lung cancer (LC) detection and management, only a very limited number of works have applied it to tissues. As such, the aim of this study was the thorough analysis of metabolic profiles of relevant LC tissues, including the most important histological subtypes (adenocarcinoma and squamous cell lung carcinoma). Mass spectrometry‐based metabolomics, along with genetic expression and histological analyses, were performed as part of this study, the widest to date, to identify metabolic alterations in tumors of the most relevant histological subtypes in lung. A total of 136 lung tissue samples were analyzed and 851 metabolites were identified through metabolomic analysis. Our data show the existence of a clear metabolic alteration not only between tumor vs. nonmalignant tissue in each patient, but also inherently intrinsic changes in both AC and SCC. Significant changes were observed in the most relevant biochemical pathways, and nucleotide metabolism showed an important number of metabolites with high predictive capability values. The present study provides a detailed analysis of the metabolomic changes taking place in relevant biochemical pathways of the most important histological subtypes of LC, which can be used as biomarkers and also to identify novel targets.

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Glutathione levels in human tumors

Cited by 480 publications

References 114 publications

Advancing the Pharmaceutical Potential of Bioinorganic Hybrid Lipid‐Based Assemblies

Advancing the Pharmaceutical Potential of Bioinorganic Hybrid Lipid‐Based Assemblies

The activity of redox-regulatory systems in the tumor and its surrounding tissues in various histological types of tumor

Metabolomic profiling of human lung tumor tissues – nucleotide metabolism as a candidate for therapeutic interventions and biomarkers

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