Glutathione-depletion reinforced enzyme catalytic activity for photothermal assisted bacterial killing by hollow mesoporous CuO

Abstract

he emergence and prevalence of drug-resistant bacteria caused by overuse of antibiotics pose new challenges to the treatment of bacterial infections. In this work, the hollow mesoporous CuO nanozymes (HM-CuO...

Systematic analysis of lysine crotonylation in human macrophages responding to MRSA infection

“…Brucella (a facultative intracellular bacterium) infection induced macrophage death depends on T4SS secretion activity ( Tian et al., 2020 ). Up-regulated catalytic activity of special protein may help host cell to eliminate bacteria ( Shi et al., 2022 ). From a model of MRSA infection for 24h murine sepsis, blood samples showed the vancomycin treatment down regulated Toll-like receptor signaling pathway and IL-1β production, but not IL-6 and TNF-α production ( Sharma-Kuinkel et al., 2013 ).…”

Reactive oxygen species-mediated CuRuOX@HA hybrid nanozymes for multidrug-resistant bacterial infections with synergistic photothermal therapy

“…2D and E, the photothermal conversion efficiency of 62.7% was calculated for CuRuO X @HA NPs using the previously reported equation, 30 which is higher than that of the single nanozymes. 26,30 This demonstrated that CuRuO X @HA NPs were expected to be ideal photothermal conversion agents with the potential to inhibit bacterial growth through photothermal inhibition.…”

“…According to the previous study, copper oxides are considered to have good photothermal characteristics. 26,27 The UV-vis-NIR spectrum of CuRuO X @HA NPs showed a wide range of absorption from the visible to the NIR region (Fig. S6, ESI †).…”

“…Moreover, some typical Cu-nanozymes such as CuO X , CuS X , Cu 2 MoS 4 , and Cu 2 WS 4 have a better catalytic capacity than that of single Cu nanozymes, and extensive research suggested that they can be used as candidates for cancer therapy and bacterial infection treatment. [26][27][28][29] However, the limited catalytic capacity of typical Cu-nanozymes is not sufficient to achieve satisfactory results.…”

A small pore black TiO2/-large pore Fe3O4 cascade nanoreactor for chemodynamic/photothermal synergetic tumour therapy

“…16,17 Nanozymes, as a new generation of artificial enzymes, have attracted a lot of attention, showing potential for tumour catalytic therapy because of their heterogeneous enzyme-mimicking a Department of Biomedical Engineering and Department of Pharmaceutical activities, low cost, high stability, tunable specificity, and robust catalytic activity. [18][19][20][21] Notably, the biological activity of natural enzymes is inextricably linked to their spatial structure. Inspired by this finding, the catalytic performance of nanozymes also should be highly dependent on the rational chemical structure design of nanomaterials.…”