Glutathione Depletion‐Induced Versatile Nanomedicine for Potentiating the Ferroptosis to Overcome Solid Tumor Radioresistance and Enhance Immunotherapy
Huijuan Song,
Hao Sun,
Ningning He
et al.
Abstract:A high level of reduced glutathione is a major factor contributing to the radioresistance observed in solid tumors. To address this radioresistance associated with glutathione, we fabricated a cinnamaldehyde (CA) polymer prodrug, referred to as PDPCA. This prodrug was created by synthesizing a pendent CA prodrug with acetal linkages in a hydrophobic block, forming a self‐assembled into a core–shell nanoparticle in aqueous media. Additionally, it encapsulated all‐trans retinoic acid (ATRA) for synchronous deliv… Show more
A facile synthetic method was developed to prepare a biocompatible acid-responsive polycarbonate containing cinnamaldehyde moieties, a potent GSH-depleting agent, for enhancing the anticancer efficacy of etoposide.
A facile synthetic method was developed to prepare a biocompatible acid-responsive polycarbonate containing cinnamaldehyde moieties, a potent GSH-depleting agent, for enhancing the anticancer efficacy of etoposide.
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