Glutathione Depletion by Xenobiotics in Coturnix coturnix japonica

Galvani, P.; Fumagalli, P; Santagostino, A.

doi:10.1007/s001289900714

Cited by 5 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, only four avian studies have used BSO and effectively decreased tGSH values (Galvani et al 1998;Marchionatti et al 2001;Galván and Alonso-Alvarez 2008;Horak et al 2010). Among them, the subject of the study was related to the present work in only two cases.…”

Section: Discussionmentioning

confidence: 99%

The Level of an Intracellular Antioxidant during Development Determines the Adult Phenotype in a Bird Species: A Potential Organizer Role for Glutathione

Romero-Haro

Alonso‐Álvarez

2015

The American Naturalist

View full text Add to dashboard Cite

Online enhancement: appendix. Dryad data: http://dx.doi.org/10.5061/dryad.1rd58.abstract: Life-history traits are often involved in trade-offs whose outcome would depend on the availability of resources but also on the state of specific molecular signals. Early conditions can influence trade-offs and program the phenotype throughout the lifetime, with oxidative stress likely involved in many taxa. Here we address the potential regulatory role of a single intracellular antioxidant in lifehistory trade-offs. Blood glutathione levels were reduced in a large sample of birds (zebra finch Taeniopygia guttata) during development using the synthesis inhibitor buthionine sulfoximine (BSO). Results revealed several modifications in the adult phenotype. BSO-treated nestlings showed lower glutathione and plasma antioxidant levels. In adulthood, BSO birds endured greater oxidative damage in erythrocytes but stronger expression of a sexual signal. Moreover, adult BSO females also showed weaker resistance to oxidative stress but were heavier and showed better body condition. Results suggest that low glutathione values during growth favor the investment in traits that should improve fitness returns, probably in the form of early reproduction. Higher oxidative stress in adulthood may be endured if this cost is paid later in life. Either the presence of specific signaling mechanisms or the indirect effect of increased oxidative stress can explain our findings.

show abstract

Section: Discussionmentioning

confidence: 99%

The Level of an Intracellular Antioxidant during Development Determines the Adult Phenotype in a Bird Species: A Potential Organizer Role for Glutathione

Romero-Haro

Alonso‐Álvarez

2015

The American Naturalist

View full text Add to dashboard Cite

show abstract

“…Depletion of sulfhydryl groups may further enhance the adverse effects of xenobiotics, perhaps by increasing the ability of metal ions to associate with other cellular ligands (Nakagawa et al, 1995;Galvani et al, 1998;Sheweita, 1998). Albeit contradictory, evidence suggests that given that intracellular concentrations of GSH are present in plasma at low micromolar concentrations (thereby providing a significant pool of nonprotein thiols to which mercuric ions can bind), it is unlikely that relevant levels of Hg will deplete GSH to induce adverse effects (Ariza et al, 1998;Zalups, 1998).…”

Section: Hg Metabolism Excretion and Mechanisms Of Actionmentioning

confidence: 95%

Toxicology and Immunotoxicology of Mercury: A Comparative Review in Fish and Humans

Sweet¹,

Zelikoff²

2001

Journal of Toxicology and Environmental Health Part B: Critical Reviews

206

View full text Add to dashboard Cite

This review addresses an important area of environmental and mammalian toxicology by evaluating and comparing mercury-induced effects upon the immune responses of two evolutionarily divergent yet immunologically-related species. The mechanisms of mercury toxicology and immunotoxicology are described herein, including supporting data from the following: sources of exposure; bioavailability and biodistribution; metabolism; and laboratory and field investigations. Based upon the studies presented, the relative sensitivities of fish and human immune cells to mercury exposure are compared and contrasted with regard to mercury's ability to stimulate and/or suppress host immunocompetence. In addition, results from immune assays are compared to mercury tissue burdens, as well as to toxicological threshold level estimates. Such comparisons may help to resolve gaps in our knowledge regarding sensitivity of immunological assays, standardization of immunotoxicological techniques between species, and the extent to which the vertebrate immune system possesses functional reserve and redundancy in response to xenobiotics. A review of this type begins to provide support for the potential usefulness of fish immune cells to serve as indicators for human immunotoxicology risk assessment. Analysis of the reviewed studies supports the following conclusions in both lower and higher vertebrates: a threshold for mercury-induced immunotoxicological effects is likely; multiple exposure scenarios involving high and/or chronic exposures leading to increased body burdens are linked to increased risk of immunomodulation; and highly exposed and/or susceptible subpopulations are at greater risk of toxicological impact.

show abstract

Porphyrin Pattern and Methemoglobin Levels in Columba livia Applied to Assess Toxicological Risk by Air Pollution in Urban Areas

Sicolo

Tringali

Orsi

et al. 2009

Arch Environ Contam Toxicol

View full text Add to dashboard Cite

The study has explored two conservative biomarkers, porphyrin pattern in guano and methemoglobin levels in blood of Columba livia, in order to assay their potential use for monitoring toxic effects induced by exposure to urban air pollution. Fieldwork was conducted between October 2003 and June 2005 in the city of Milan, Italy, by sampling the pigeons in different areas almost twice a week. Six air contaminants, CO, PM10, NO(2), O(3), SO(2), and C(6)H(6), plus polycyclic aromatic hydrocarbons (PAHs) in fine particles, temperature, and UV index, were considered. Protoporphyrins from pigeon excreta sampled outdoors were always higher than in indoor animals, particularly in winter. A positive correlation (p < 0.001) of protoporphyrin with PAHs was observed. In terms of the values of methemoglobinemia, animals exposed to urban air showed significant differences from season to season but only in summer and autumn did the outdoor pigeons show higher values than indoor animals. In summer, a regression model with a positive correlation between O(3) and benzene was determined (p < 0.01). The use of Columba livia as a sentinel for urban air pollution as well as for detecting complex interactions between contaminants in the urban air pollutant mixture was discussed.

show abstract

Glutathione Depletion by Xenobiotics in Coturnix coturnix japonica

Cited by 5 publications

References 5 publications

The Level of an Intracellular Antioxidant during Development Determines the Adult Phenotype in a Bird Species: A Potential Organizer Role for Glutathione

The Level of an Intracellular Antioxidant during Development Determines the Adult Phenotype in a Bird Species: A Potential Organizer Role for Glutathione

Toxicology and Immunotoxicology of Mercury: A Comparative Review in Fish and Humans

Porphyrin Pattern and Methemoglobin Levels in Columba livia Applied to Assess Toxicological Risk by Air Pollution in Urban Areas

Contact Info

Product

Resources

About