Glutathione-capped fluorescent gold nanoclusters for dual-modal fluorescence/X-ray computed tomography imaging

Zhang, Chunlei; Zhou, Zhijun; Qian, Qirong; Gao, Guo; Li, Chao; Feng, Lili; Wang, Qing; Cui, Daxiang

doi:10.1039/c3tb20784f

Cited by 106 publications

(69 citation statements)

References 34 publications

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“…In our previous work, with the aim of finding early gastric cancer, we screen out some new biomarkers associated with early gastric cancer and develop novel ultrasensitive detection methods [8][9]. We also designed and fabricated some multifunctional nanoprobes for targeted imaging and simultaneous therapy of subcutaneous and in situ gastric cancer tissues with 5 mm in diameter [10][11][12][13][14][15][16][17][18][19][20][21][22]. Among those multifunctional nanoprobes, RGDconjugated gold nanorods could target tumor tissues and kill tumor cells via photothermal therapy [14], exhibiting potential clinical application prospects.…”

Section: Introductionmentioning

confidence: 99%

EGFR Antibody Conjugated Bimetallic Au@Ag Nanorods for Enhanced SERS-Based Tumor Boundary Identification, Targeted Photoacoustic Imaging and Photothermal Therapy

Chen¹,

Zhang²,

Yang³

et al. 2016

Nano BioMed ENG

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The development of multifunctional nanoprobes for simultaneous targeted imaging, tumor boundary identification and photothermal therapy of gastric cancer has become a great challenge. Herein, EGFR monoclonal antibody-conjugated Au@Ag nanorods decorated with DTNB nanoprobes (5,5'-Dithiobis-(2-nitrobenzoic acid)) (EGFR-Au@Ag NR nanotags) were prepared and characterized. Their biocompatibility was analyzed by MTT assay. In vitro studies show that EGFR-Au@Ag NR nanotags own good biocompatibility and capability of targeting and entering into gastric cancer MGC803 cells, silver nano-film layer on the surface of gold nanorods remarkably enhance surfaceenhanced rama spectra (SERS) signal, enhanced photoacoustic imaging efficacy and photothermal conversion efficiency of gold nanorods. In vivo studies show that prepared nanotags could target actively gastric cancer cells at 2 h post-injection, and distributed in the tumor site, exhibited enhanced SERS signals to display clearly tumor boundary, enhanced photoacoustic imaging to display clearly tumor boundary. Under 1 w/cm 2 laser irradiation, tumor growth was remarkably inhibited by local photothermal therapy. In conclusion, high performance EGFR-antibody conjugated Au@Ag nanorod-DTNB nanoprobes exhibit great potential in applications such as targeted photoacoustic imaging, simultaneous tumor boundary identification and selective photothermal therapy of gastric cancer in the near future.

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Section: Introductionmentioning

confidence: 99%

EGFR Antibody Conjugated Bimetallic Au@Ag Nanorods for Enhanced SERS-Based Tumor Boundary Identification, Targeted Photoacoustic Imaging and Photothermal Therapy

Chen¹,

Zhang²,

Yang³

et al. 2016

Nano BioMed ENG

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“…[134,135] On a mice model, using GS-GNPs functionalized with FA, Zhang et al confirmed the possibility to image cells in-vitro, and to selectively image induced tumors in-vivo. [136] This system has been proven to be almost not toxic to tested cells (human gastric cancer MGC-803 and gastricepithelial GES-1) and showed good biocompatibility in-vivo as well.…”

Section: In-vitro Applicationsmentioning

confidence: 98%

Luminescent gold nanoclusters as biocompatible probes for optical imaging and theranostics

et al. 2016

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“…For instance, Zhang et al reported a novel synthetic approach for synthesizing FA-conjugated GSH-AuNCs, and explored their single fluorescence imaging (FI) and X-ray computed tomography (CT) imaging capabilities. The dual-modal FI and CT imaging for cells showed that this FA conjugated GSH-AuNCs were promising fluorescent probes [138]. Furthermore, FI and magnetic resonance imaging (MRI) dual-modal imaging through coupling AuNCs with paramagnetic agents is also very popular [139].…”

Section: Biological Imagingmentioning

confidence: 99%

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

Wang

Zhu

2017

J. Anal. Test.

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Fluorescent gold nanoclusters (AuNCs) have recently emerged as a novel kind of promising fluorescent probes for high-performance sensors and bioimaging because of their ultrasmall size (\3 nm), strong luminescence, good photostability, and excellent biocompatibility. Over the past decade, we have witnessed growing popularity of AuNCs in analytical applications and enormous efforts have been devoted to their development. In this review, we provide an update on recent advances in the development of AuNCs in terms of physicochemical properties, synthesis strategies, and bioapplications. The optical, electrochemical, catalytical, and solvatochromic properties of AuNCs are first summarized, which are followed by different ligands or template-assisted controllable synthetic methods. Afterwards functionalization of AuNCs is described in terms of ligand exchange, bioconjugation, and noncovalent interaction. We then focus on the applications of AuNCs as fluorescent probes for detection of metal ions, inorganic anions, small biomolecules, proteins, nucleic acids, drug molecules, pH, and temperature. We also summarize the usage of metal NCs in cellular and in vivo targeting and imaging. Finally, we conclude with a brief look at the future challenges and prospects of the development of AuNCs.

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Glutathione-capped fluorescent gold nanoclusters for dual-modal fluorescence/X-ray computed tomography imaging

Cited by 106 publications

References 34 publications

EGFR Antibody Conjugated Bimetallic Au@Ag Nanorods for Enhanced SERS-Based Tumor Boundary Identification, Targeted Photoacoustic Imaging and Photothermal Therapy

EGFR Antibody Conjugated Bimetallic Au@Ag Nanorods for Enhanced SERS-Based Tumor Boundary Identification, Targeted Photoacoustic Imaging and Photothermal Therapy

Luminescent gold nanoclusters as biocompatible probes for optical imaging and theranostics

Fluorescent Gold Nanoclusters: Promising Fluorescent Probes for Sensors and Bioimaging

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