Glutathione and riboflavin status in patients undergoing home nocturnal hemodialysis versus standard hemodialysis

Abstract

ObjectivesTo examine whether improved plasma cysteine (tCys) clearance in patients receiving home nocturnal hemodialysis (HNHD) (7 hrs/session, 6 nights/wk), influenced their erythrocyte (RBC) glutathione (GSH) concentration and riboflavin status, compared to patients on standard hemodialysis (SHD) (4 hrs/session, 3 d/wk).MethodsWe measured RBC GSH concentration by liquid chromatography tandem mass spectrometry & riboflavin status by RBC GSH reductase activity coefficient (EGRAC) in 15 HNHD, 15 SHD & 15 healthy controls (HC) participants. Estimated dietary protein intake (PRO), and plasma tCys, homocysteine (tHcy), C‐reactive protein (CRP) and vitamin C were also determined.Median (25th, 75th percentile)ConclusionRBC GSH and riboflavin status may be unaffected by hemodialysis modality in well nourished HD patients. Supported by Kidney Foundation of Canada