Glutathione and cystamine functionalized MoS2core-shell nanoparticles for enhanced electrochemical detection of doxorubicin

Selvi, Subash Vetri; Prasannan, Adhimoorthy; Chen, Shen‐Ming; Vadivelmurugan, Adhisankar; Tsai, Hsieh‐Chih; Lai, Juin‐Yih

doi:10.1007/s00604-020-04642-8

Cited by 19 publications

(5 citation statements)

References 33 publications

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“…A schematic representation of a three-electrode system setup toward the target analyte is displayed in Figure a. Electrochemical impedance spectroscopy (EIS) capacities are conducted to provide the charge transfer resistance ( R ct ) of modified GCEs with respect to the bare electrode in 0.1 M KCl containing 5 mM [Fe(CN) 6 ] 3–/4– , which reveals variability in R ct values attributed to surface modification. − As observed in Figure b, the Nyquist plot of LaV/h-BN/GCE exhibits a smaller R ct value of 81.19 Ω·cm 2 as compared to a bare GCE (426.72 Ω·cm 2 ), LaV (275.04 Ω·cm 2 ), and h-BN (128.51 Ω·cm 2 ) modified electrodes. A smaller R ct value entails more facetious electron transfer kinetics signifying superior electrocatalytic activity for the LaV/h-BN/GCE composite.…”

Section: Resultsmentioning

confidence: 99%

“…The direct relationship is validated by the calibration curve in Figure b with the regression correlation coefficient ( R 2 ) of 0.991. The proposed sensor shows confirmations of remarkable electrocatalytic activity with the attainment of values as low as a detection limit of 0.5 nM and wide linear responses of 0.001–89 μM, and values are calculated using the standard formula − The evaluation of the analytical features of the LaV/h-BN-based electrochemical platform (Table ) signifies its efficient performance compared to those of previously reported studies, where, from the i – t curve, it is obtained to be 5 s on average for each and every addition of the analyte. The improved performance of the sensor can be recognized in accordance with the synergistic interactions between LaV and h-BN, the creation of electroactive edge sites, better electronic conductivity, and morphological encapsulation supporting electron transfer.…”

Section: Resultsmentioning

confidence: 99%

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Synergy of the LaVO₄/h-BN Nanocomposite: A Highly Active Electrocatalyst for the Rapid Analysis of Carbendazim

et al. 2021

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In the field of agriculture fungicides are vital, providing the most important ecosystem service for food production. The widespread use of these chemicals can significantly lead to various ecotoxicological threats with adverse effects, such as environmental changes, microbial resistance, and phytotoxicity. Electrochemical sensors offer enormous potential for the identification and monitoring of hazardous substances in accordance with their constructive characteristics, namely, precision, accuracy, sensitivity, and selectivity, over traditional analytical techniques. Here, we thus report the synthesis of the lanthanum vanadate/hexagonal boron nitride (LaV/h-BN) composite for the electrochemical determination of carbendazim (CZ), which is a widely used fungicide for disease management with critical risks associated with its overexposure. The combination of LaV and h-BN accelerates the formation of active sites, facilitating faster charge transfer and higher electronic conductivity. The synergistic effects greatly improve the preference of the modified electrode with increased sensitivity, a lower limit of detection, and wide linear responses toward CZ detection. The existence of variable oxidation states in the orthovanadate together with the unique properties of h-BN mark LaV/h-BN as an advanced material for specific applications in the family of rare-earth metal orthovanadate. Also, the deep eutectic solvent-assisted synthesis of the material creates an environmentally efficient system with reduced energy requisites to allow for applications in effective environmental monitoring.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Synergy of the LaVO₄/h-BN Nanocomposite: A Highly Active Electrocatalyst for the Rapid Analysis of Carbendazim

et al. 2021

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“…Its mechanism of action involves inhibiting DNA replication and transcription in cancer cells [ 4 , 5 ]. However, DOX has several adverse effects on the human body, including nausea, vomiting, liver failure, local tissue necrosis, and potential heart failure [ 6 , 7 ]. Therefore, it is crucial to closely monitor the dosage of DOX in human biological fluids and further regulate its concentration.…”

Section: Introductionmentioning

confidence: 99%

N-Doped Graphene Quantum Dots Confined within Silica Nanochannels for Enhanced Electrochemical Detection of Doxorubicin

Zhang,

Zhou,

Yan

et al. 2023

Molecules

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Herein, we describe a fast and highly sensitive electrochemical sensor for doxorubicin (DOX) detection based on the indium tin oxide (ITO) modified with a binary material consisting of vertically-ordered mesoporous silica films (VMSFs) and N-doped graphene quantum dots (NGQDs). VMSFs, with high permeability and efficient molecular transport capacity, is attached to the ITO electrode via a rapid and controllable electrochemical method, which can serve as a solid template for the confinement of numerous NGQDs through facile electrophoresis. By virtue of the excellent charge transfer capacity, π-π and electrostatic preconcentration effects of NGQDs, as well as the electrostatic enrichment ability of VMSF, the presented NGQDs@VMSF/ITO shows amplified electrochemical signal towards DOX with a positive charge, resulting in good analytical performance in terms of a wide linear range (5 nM~0.1 μM and 0.1~1 μM), high sensitivity (30.4 μA μM−1), and a low limit of detection (0.5 nM). Moreover, due to the molecular sieving property of VMSF, the developed NGQDs@VMSF/ITO sensor has good selectivity and works well in human serum and urine samples, with recoveries of 97.0~109%, thus providing a simple and reliable method for the direct electrochemical analysis of DOX without complex sample pretreatment procedures.

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“…In recent years, many methods have been developed for the detection of DOX, such as high-performance liquid chromatography mass spectrometry (HPLC-MS), [6] mass spectrometry (MS), [7] capillary electrophoresis (CE) [8] and electrochemical methods. [9,10] Although these techniques have produces good performances for DOX analysis, there is still the need for increased effort to develop a sensitive, quick responding and inexpensive strategy for monitoring DOX in plasma.…”

Section: Introductionmentioning

confidence: 99%

A ratiometric fluorescence strategy based on copper nanoclusters/carbon dots for sensitive detection of doxorubicin

Fan

Chen

et al. 2022

Luminescence

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Sensitive detection of doxorubicin (DOX) is critical for clinical theranostics. A novel ratiometric fluorescence strategy based on the inner filter effect (IFE) has been established for the sensitive detection of DOX by designing a ratiometric fluorescence probe. In the presence of DOX, the fluorescence intensity of copper nanoclusters (CuNCs) at 485 nm decreases, and the fluorescence intensity of carbon dots at 560 nm increases. Therefore, DOX can be quantitatively detected by measuring the ratio of the fluorescence intensities at 560 and 485 nm (F 560 /F 485 ). The F 560 / F 485 ratio exhibits a linear correlation with the DOX concentration in the range from 1.0 Â 10 À8 M to 1.0 Â 10 À4 M with the detection limit of 3.7 nM. Furthermore, this method was also successfully applied to the analysis of DOX in human plasma samples, affording an effective platform for drug safety management.

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Glutathione and cystamine functionalized MoS2core-shell nanoparticles for enhanced electrochemical detection of doxorubicin

Cited by 19 publications

References 33 publications

Synergy of the LaVO₄/h-BN Nanocomposite: A Highly Active Electrocatalyst for the Rapid Analysis of Carbendazim

Synergy of the LaVO₄/h-BN Nanocomposite: A Highly Active Electrocatalyst for the Rapid Analysis of Carbendazim

N-Doped Graphene Quantum Dots Confined within Silica Nanochannels for Enhanced Electrochemical Detection of Doxorubicin

A ratiometric fluorescence strategy based on copper nanoclusters/carbon dots for sensitive detection of doxorubicin

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Glutathione and cystamine functionalized MoS2core-shell nanoparticles for enhanced electrochemical detection of doxorubicin

Cited by 19 publications

References 33 publications

Synergy of the LaVO4/h-BN Nanocomposite: A Highly Active Electrocatalyst for the Rapid Analysis of Carbendazim

Synergy of the LaVO4/h-BN Nanocomposite: A Highly Active Electrocatalyst for the Rapid Analysis of Carbendazim

N-Doped Graphene Quantum Dots Confined within Silica Nanochannels for Enhanced Electrochemical Detection of Doxorubicin

A ratiometric fluorescence strategy based on copper nanoclusters/carbon dots for sensitive detection of doxorubicin

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Synergy of the LaVO₄/h-BN Nanocomposite: A Highly Active Electrocatalyst for the Rapid Analysis of Carbendazim

Synergy of the LaVO₄/h-BN Nanocomposite: A Highly Active Electrocatalyst for the Rapid Analysis of Carbendazim