Glutaraldehyde collagen cross‐linking stabilizes resin–dentin interfaces and reduces bond degradation

Lee, Joshua; Sabatini, Camila

doi:10.1111/eos.12317

Cited by 34 publications

(20 citation statements)

References 44 publications

(53 reference statements)

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“…A total of 50 articles were included in the qualitative analysis. Of these, 5 articles were not considered for the meta-analysis because two of them did not express the BS data as means and SDs [ 76 , 77 ], and in 3 articles the number of specimens used could not be retrieved [ 78 , 79 , 80 ], totalling 45 articles considered for the quantitative analysis [ 17 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 ]. A flowchart designating the study selection process according to the PRISMA statement is presented in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis

Hardan

Daood

Bourgi

et al. 2022

Cells

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This study aimed to identify the role of crosslinking agents in the resin–dentin bond strength (BS) when used as modifiers in adhesives or pretreatments to the dentin surface through a systematic review and meta-analysis. This paper was conducted according to the directions of the PRISMA 2020 statement. The research question of this review was: “Would the use of crosslinkers agents improve the BS of resin-based materials to dentin?” The literature search was conducted in the following databases: Embase, PubMed, Scielo, Scopus, and Web of Science. Manuscripts that reported the effect on the BS after the use of crosslinking agents were included. The meta-analyses were performed using Review Manager v5.4.1. The comparisons were performed by comparing the standardized mean difference between the BS values obtained using the crosslinker agent or the control group. The subgroup comparisons were performed based on the adhesive strategy used (total-etch or self-etch). The immediate and long-term data were analyzed separately. A total of 50 articles were included in the qualitative analysis, while 45 articles were considered for the quantitative analysis. The meta-analysis suggested that pretreatment with epigallocatechin-3-gallate (EGCG), carbodiimide, ethylenediaminetetraacetic acid (EDTA), glutaraldehyde, and riboflavin crosslinking agents improved the long-term BS of resin composites to dentin (p £ 0.02). On the other hand, the use of proanthocyanidins as a pretreatment improved both the immediate and long-term BS values (p ≤ 0.02). When incorporated within the adhesive formulation, only glutaraldehyde, riboflavin, and EGCG improved the long-term BS to dentin. It could be concluded that the application of different crosslinking agents such as carbodiimide, EDTA, glutaraldehyde, riboflavin, and EGCG improved the long-term BS of adhesive systems to dentin. This effect was observed when these crosslinkers were used as a separate step and when incorporated within the formulation of the adhesive system.

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Section: Resultsmentioning

confidence: 99%

Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis

Hardan

Daood

Bourgi

et al. 2022

Cells

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“…It is an alcoholic solution that contains three resin monomers (HEMA, UDMA, and 4-META), two organic acids (polyacrylic and maleic) and 5% glutaraldehyde as desensitizer agent 24 . In dentistry, besides desensitizer agent, glutaraldehyde has been used in many different ways such as antibacterial, cross-linker agent, and MMPs inhibitor in order to increase the resistance of collagen fibrils against enzymatic degradation [24][25][26] . Its ability as MMPs inhibitor and cross-linker agent may have played an important role to maintain the stability of the dentin μTBS after one year 27,28 .…”

Section: Discussionmentioning

confidence: 99%

Influence of desensitizers agents on the dentin bond strength after one-year water storage

2020

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Aim: Evaluate the effect of adhesives systems combined with desensitizer agents on the microtensile bond strength (μTBS) of a composite resin to dentin. Methods: Cervical dentin of thirty-two human molars were used to simulate hypersensitivity areas. The teeth were divided into four groups (n=8), according to the type of adhesive system and desensitizer agents. No desensitizer was used in the control (Clearfil SE Bond – CS). Two experimental groups were pretreated with either MS Coat Bond (MS) or Biofluorid 12 (BF) immediately prior to bonding with CS. The last group corresponded to Gluma Comfort Bond + Desensitizer (GC) application. After dentin treatments, a composite block was built-up on dentin surface and after 24 hours teeth were serially sectioned to obtain bonded bean specimens. Beams were stored in water for 24 hours or one year. Subsequently, the specimens were submitted to the μTBS test. Data were analyzed by two-way mixed ANOVA and Bonferroni’s test (α = 0.05). Results: At 24 hours, there was no significant difference in μTBS among groups. However, at one year, dentin treated with MS or BF demonstrated significantly lower μTBS of CS to dentin compared to control and GC, which kept their μTBS stable. Conclusion: The effect of MS and BF desensitizer agents on the μTBS of CS to dentin did not reduce the μTBS at 24 hours, but it decreases significantly after one year.

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“…Glutaraldehyde is an effective dentin adhesive for enhancement of the bond strength of dentin and resin. 22,23 However, the clinical applications of glutaraldehyde are greatly limited by its toxicity; thus, there is an urgent need for less toxic alternatives. Some natural products with low toxicity have been shown to exhibit biological functions that could enhance dentin strength and dentin collagen cross-linking, thereby attracting attention from researchers.…”

Section: Discussionmentioning

confidence: 99%

Effect of tea root-derived proanthocyanidin fractions on protection of dentin collagen

et al. 2019

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Objectives Proanthocyanidins (PAs) have been widely used as effective agents for dentin collagen cross-linking to enhance the biomechanics and biostability of dentin in vitro. However, the effects and protective mechanisms of various tea root-derived PA components on dentin remain undefined. This study evaluated the effects of these tea root-derived PA components on dentin biomechanics and biostability. Methods In this study, ethyl acetate and n-butyl alcohol were used to extract PAs with different degrees of polymerization from tea roots; the effects of these PA extracts on dentin were evaluated. Results Dentin was treated with glutaraldehyde, ethyl acetate, n-butyl alcohol, or water. PAs with a high degree of polymerization, extracted using n-butyl alcohol, were able to more effectively improve dentin collagen cross-linking, increase resistance to bacterial collagenase digestion, and enhance dentin elasticity, relative to treatment with glutaraldehyde or PAs with a low degree of polymerization (extracted using ethyl acetate). Additionally, treatment with aqueous extract of tea roots was detrimental to dentin stability and function. Conclusions PAs with a high degree of polymerization were effective for dentin protection and restoration in vitro, suggesting clinical treatment potential for tea root-derived PAs.

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Glutaraldehyde collagen cross‐linking stabilizes resin–dentin interfaces and reduces bond degradation

Cited by 34 publications

References 44 publications

Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis

Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis

Influence of desensitizers agents on the dentin bond strength after one-year water storage

Effect of tea root-derived proanthocyanidin fractions on protection of dentin collagen

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