Glutamine supplementation prevents collagen expression damage in healthy urinary bladder caused by radiotherapy

Effects of oral glutamine during abdominal radiotherapy on chronic radiation enteritis: A randomized controlled trial

“…Glutamine also can regulate collagen production, and thereby modulate the healing of irradiated tissue [18]. In rats, Gln supplementation prevents acute changes in extracellular matrix and collagen expression in the urinary bladder after exposure to radiation, but the effects on fibrosis have not been studied [19]. The same amino acid increases the transcription of the collagen gene in skin fibroblasts, suggesting that the type of tissue and stimulus may influence the effects of glutamine [20].…”

Proline Precursors and Collagen Synthesis: Biochemical Challenges of Nutrient Supplementation and Wound Healing

“…Most of the benefits of supplemental glutamine appear to involve improved gut permeability and protein synthesis, normalization of serum levels, and decreased length of hospital stay (40). In addition, there is some evidence that preinjury glutamine administration can prevent damage to collagen expression caused by external beam radiation (41). Furthermore, a mixture of BCAAs and glutamine improved the fractional synthesis rate of dermal tropocollagen by a factor of 2.04 6 0.54 (mean 6 SE) in an immunocompetent mouse irradiation model (42).…”