Glutamine-Enriched Total Parenteral Nutrition Enhances Plasma Glutathione in the Resting State

Denno, Ryusuke; Rounds, Jan D.; Faris, Ramona; Holejko, Lourdes B.; Wilmore, Douglas W.

doi:10.1006/jsre.1996.0077

Cited by 55 publications

(25 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 Severe trauma does not decrease plasma levels of glutathione when increased support of the amino acids related to glutathione metabolism is provided. Denno et al 13 reported that glutamine-enriched TPN enhanced plasma glutathione stores in the resting state, and they suggested that glutamine was rate limiting for glutathione biosynthesis during TPN infusion. This study did not show differences between the groups in the number of nosocomial infections, presence of metabolic disorders, mean MV days or ICU days, death during the study period, or survivors at 1 mo.…”

Section: Discussionmentioning

confidence: 98%

The Effect of Intravenous Alanyl-Glutamine Supplementation on Plasma Glutathione Levels in Intensive Care Unit Trauma Patients Receiving Enteral Nutrition: The Results of a Randomized Controlled Trial

Eroğlu

2009

Anesthesia &Amp; Analgesia

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

The Effect of Intravenous Alanyl-Glutamine Supplementation on Plasma Glutathione Levels in Intensive Care Unit Trauma Patients Receiving Enteral Nutrition: The Results of a Randomized Controlled Trial

Eroğlu

2009

Anesthesia &Amp; Analgesia

View full text Add to dashboard Cite

show abstract

“…Furthermore, the dose of glutamine we chose seems safe for human administration. Denno et al 30 demonstrated that a continuous infusion of 0.57 g/kg per day of glutamine did not induce renal and liver dysfunction without producing significant elevations in ammonia and glutamate levels.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Glutamine Administration Induces Heat-Shock Protein 70 Expression and Attenuates Cardiopulmonary Bypass–Induced Inflammatory Response by Regulating Nitric Oxide Synthase Activity

et al. 2002

View full text Add to dashboard Cite

Background-Heat-shock protein 70 (HSP70) plays a major role in the pathophysiology of inflammation, and the induction of HSP70 before the onset of inflammation can reduce organ damage through a self-protective system. Glutamine is known to be an inducer of HSP70, and its preoperative administration seems useful in attenuating cardiopulmonary bypass (CPB)-induced inflammatory response. Methods and Results-Adult male Sprague-Dawley rats (group G, received 100 mg/kg of glutamine via the right jugular vein 3 times per day for 1 week and just before the initiation of CPB; group C served as control) underwent CPB (60 minutes, 100 mL/kg per minute, 34°C) and were killed 3 hours after the termination of CPB. Group G showed significantly lower plasma concentrations of interleukin-6 and interleukin-8 after CPB termination. Myocardial and respiratory damages were significantly attenuated in group G, as evidenced by Langendorff perfusion, respiratory index, and neutrophil adherence. HSP70 expressions in the heart, lung, and liver were detected only in group G before CPB and were markedly stronger in group G 3 hours after CPB termination. Although plasma nitrateϩnitrite concentrations were not significantly different between the groups, endothelial-constitutive nitric oxide synthase (NOS) activity was markedly preserved and inducible NOS activity was markedly attenuated in the tissues of group G. Conclusions-These results suggest that preoperative glutamine administration induces HSP70 expression before CPB and attenuates CPB-induced inflammation by regulating NOS activity, which may be a prospective management for conferring tolerance to CPB-induced inflammatory response through a self-protective mechanism. (Circulation. 2002; 106:2601-2607.)

show abstract

“…Supplementation with Gln provides an energy substrate to the intestinal metabolism, increases the antioxidant capacity of the intestine, promotes intestinal mucosal cell proliferation and accelerates epithelial cell repair. Studies showed (1) that Gln affects the composition of the intestinal bacterial flora by restraining the growth of Gram-negative bacteria [28] and (2) that Gln promotes the secretion of IgA in intestinal mucosal lymphoid tissue and reduces the attachment and colonization of bacteria in the intestinal mucosa [29]. The reduced bacterial translocation and endotoxins in the liver system inactivate hepatic Kupffer cells, inhibit the release of TNF-α, IL-1 and other cytokines, and reduce the production of oxygen free radicals, therefore protecting the liver from these sources of damage [30].…”

Section: Discussionmentioning

confidence: 99%

Preconditioning with Glutamine Protects against Ischemia/Reperfusion-Induced Hepatic Injury in Rats with Obstructive Jaundice

Dai

Peng

et al. 2014

Pharmacology

View full text Add to dashboard Cite

Objective: To ascertain whether glutamine (Gln) pretreatment protects rats with obstructive jaundice from hepatic ischemia/reperfusion (I/R) injury and to determine the underlying molecular mechanisms. Methods: An obstructive jaundice rat model was developed by bile duct ligation. On the first day after the operation, all rats were randomized into two groups and received oral Gln or normal saline (NS) daily for 7 days. Then both groups underwent a 15-min liver ischemia via the Pringle maneuver. Blood samples as well as liver and intestinal tissues were harvested and measured after 1, 6 and 24 h of reperfusion. Results: The results showed that the histological morphology of the liver and intestinal tissues significantly improved in the Gln group after I/R injury compared with the NS group. Serum proteins and enzymes associated with hepatic function also significantly improved in the Gln group. The level of glutathione increased and the levels of malondialdehyde and myeloperoxidase decreased in the Gln group. The levels of interleukin-1β and tumor necrosis factor-α decreased in the Gln group. Moreover, bcl-2 protein expression was upregulated and intercellular adhesion molecule 1 and bax protein expression downregulated in the Gln group; the caspase 3 mRNA level significantly increased in the Gln group. Conclusions: The study demonstrates that preconditioning with Gln significantly improves hepatic structure and function after I/R injury in rats with obstructive jaundice. The protective effect of Gln was mediated by the inhibition of reactive oxygen species and inflammation as well as a reduction in hepatocyte apoptosis.

show abstract

Glutamine-Enriched Total Parenteral Nutrition Enhances Plasma Glutathione in the Resting State

Cited by 55 publications

References 6 publications

The Effect of Intravenous Alanyl-Glutamine Supplementation on Plasma Glutathione Levels in Intensive Care Unit Trauma Patients Receiving Enteral Nutrition: The Results of a Randomized Controlled Trial

The Effect of Intravenous Alanyl-Glutamine Supplementation on Plasma Glutathione Levels in Intensive Care Unit Trauma Patients Receiving Enteral Nutrition: The Results of a Randomized Controlled Trial

Preoperative Glutamine Administration Induces Heat-Shock Protein 70 Expression and Attenuates Cardiopulmonary Bypass–Induced Inflammatory Response by Regulating Nitric Oxide Synthase Activity

Preconditioning with Glutamine Protects against Ischemia/Reperfusion-Induced Hepatic Injury in Rats with Obstructive Jaundice

Contact Info

Product

Resources

About