Glutamine depletion impairs cellular stress response in human leucocytes

Specific amino acids in the critically ill patient—Exogenous glutamine/arginine: A common denominator?

“…HSPs protect each cell against toxic agents and the whole body against pathologic insults (25). Wischmeyer et al (30) found a dose-dependent effect of glutamine supply on HSP72 expression in human blood mononuclear cells, while Oehler et al (31) observed a decrease in HSP70 expression in human lymphocytes when subjects were on a glutaminedeprived diet (25,30,31).…”

Stressing Out Over Survival: Glutamine as an Apoptotic Modulator

“…Oehler et al showed that reduction of GLN levels from 0.5 mM to 0.125 mM decreased HSP70 induction by 40% in heat-shocked (42°C) primary human lymphocytes [87], and likewise, reduction in ambient GLN from 2.0 mM to 0.06 mM dramatically reduced cell viability and HSP70 expression in isolated human monocytes chronically heat-shocked in the physiological range (41°C) [88]. Moreover, this same group has recently shown that GLN-starved peripheral blood monocytes exhibit defective ubiquitin-mediated proteasomal turnover of key cellular proteins [89].…”

Mécanismes d’action potentiels de la glutamine chez le patient agressé

“…De nombreuses études in vitro [39,40] ou in vivo chez l'animal [12,41] ont montré un effet inducteur de la glutamine sur l'expression des HSP avec réduction des atteintes cellulaires et de la mortalité. Nous avons précédemment montré que l'apport de glutamine augmente l'expression de l'HSP32 ou hème oxygénase-1 au niveau duodénal chez le volontaire sain [42].…”