Glutamine antagonist JHU083 improves psychosocial behavior and sleep deficits in EcoHIV-infected mice

Bell, Benjamin J.; Hollinger, Kristen R.; Deme, Pragney; Sakamoto, Shinji; Hasegawa, Yuto; Volsky, David J.; Kamiya, Atsushi; Haughey, Norman J.; Zhu, Xiaolei; Slusher, Barbara S.

doi:10.1016/j.bbih.2022.100478

Cited by 3 publications

(1 citation statement)

References 70 publications

(107 reference statements)

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“…This can support the harmful effect of the increase in aggressive PA in our ASD participants compared with controls [55]. The suggested link between increased aggressive PA, glutamate excitotoxicity as a neurochemical characteristic of an autistic brain, and sleep disruption as a comorbidity in ASD patients could find support in the work of Bell et al [56], in which they proved the relationship between glutamate excitotoxicity and sleep deficits in EcoHIV-infected mice.…”

Section: Vigorous Pa and Sleep Disruptions In Asd Patientssupporting

confidence: 74%

Children with Autism Spectrum Disorder Exhibit Elevated Physical Activity and Reduced Sedentary Behavior

Alhowikan,

Elamin,

Aldayel

et al. 2023

Brain Sciences

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According to previous research, individuals with autism spectrum disorder (ASD) have lower levels of physical activity than their typically developed (TD) counterparts. There have been conflicting reports about physical activity (PA) levels in people with ASD. Given the conflicting evidence, further investigation is required. We believe that evaluating PA in individuals with ASD is critical in order to offer PA intervention plans aiming at increasing their health-related physical fitness on a daily, systematic, and individualized basis. In the current study, an ActiGraph monitor (GT3X+) was used to accurately measure PA and sedentary activity in 21 children with autism aged 6.43 ± 2.29 years and 30 TD children aged 7.2 ± 3.14 years. Our data indicated that while the light and moderate activity counts were not significantly different between the two groups, the vigorous activity was significantly higher in ASD compared to TD. This finding was attributed to ASD characteristic stereotypy and self-stimulating behaviors. The significantly higher vigorous PA is discussed in relation to altered neurochemistry, oxidative stress, and neuroinflammation as etiological mechanisms in ASD. This research provides a better understanding of the status of PA participation in individuals with ASD.

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Section: Vigorous Pa and Sleep Disruptions In Asd Patientssupporting

confidence: 74%

Children with Autism Spectrum Disorder Exhibit Elevated Physical Activity and Reduced Sedentary Behavior

Alhowikan,

Elamin,

Aldayel

et al. 2023

Brain Sciences

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Therapeutic resurgence of 6-diazo-5-oxo-l-norleucine (DON) through tissue-targeted prodrugs

Novotná,

Tenora,

Slusher

et al. 2024

The Discovery of New Medicines in Academia

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Unveiling the intersection: ferroptosis in influenza virus infection

Letafati,

Taghiabadi,

Ardekani

et al. 2024

Virol J

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The influenza virus (IFV) imposes a considerable health and economic burden globally, requiring a comprehensive understanding of its pathogenic mechanisms. Ferroptosis, an iron-dependent lipid peroxidation cell death pathway, holds unique implications for the antioxidant defense system, with possible contributions to inflammation. This exploration focuses on the dynamic interplay between ferroptosis and the host defense against viruses, emphasizing the influence of IFV infections on the activation of the ferroptosis pathway. IFV causes different types of cell death, including apoptosis, necrosis, and ferroptosis. IFV-induced ferroptotic cell death is mediated by alterations in iron homeostasis, intensifying the accumulation of reactive oxygen species and promoting lipid peroxidation. A comprehensive investigation into the mechanism of ferroptosis in viral infections, specifically IFV, has great potential to identify therapeutic strategies. This understanding may pave the way for the development of drugs using ferroptosis inhibitors, presenting an effective approach to suppress viral infections.

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Glutamine antagonist JHU083 improves psychosocial behavior and sleep deficits in EcoHIV-infected mice

Cited by 3 publications

References 70 publications

Children with Autism Spectrum Disorder Exhibit Elevated Physical Activity and Reduced Sedentary Behavior

Children with Autism Spectrum Disorder Exhibit Elevated Physical Activity and Reduced Sedentary Behavior

Therapeutic resurgence of 6-diazo-5-oxo-l-norleucine (DON) through tissue-targeted prodrugs

Unveiling the intersection: ferroptosis in influenza virus infection

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