Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain

Zhang, Mingming; Geng, Anqi; Chen, Kun; Wang, Jian; Wang, Pan; Qiu, Xin-Tong; Gu, Jianying; Fan, Hongwei; Zhu, Da-Yu; Yang, Shan-Ming; Chen, Qi-Yu; Zhou, Zhaoxiang; Fan, Boyuan; Bai, Yang; Xing, Ke-Ke; Feng, Jia-Ming; Wang, Jun-Da; Chen, Yan; Lu, Ya-Cheng; Cao, Peng; Kaang, Bong‐Kiun; Zhuo, Min; Li, Yunqing; Chen, Tao

doi:10.1016/j.neuron.2022.03.030

Cited by 64 publications

(32 citation statements)

References 67 publications

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“…Increased excitatory synaptic transmission in the BLA is important for pain sensation ( 27 ). Therefore, we evaluated how increased excitatory synaptic transmission impacts pain-induced hyperactivity of BLA Glu neurons.…”

Section: Resultsmentioning

confidence: 99%

Distinct basolateral amygdala excitatory inputs mediate the somatosensory and aversive-affective components of pain

Meng

Yue

Liu

et al. 2022

Journal of Biological Chemistry

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Section: Resultsmentioning

confidence: 99%

Distinct basolateral amygdala excitatory inputs mediate the somatosensory and aversive-affective components of pain

Meng

Yue

Liu

et al. 2022

Journal of Biological Chemistry

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“…From the aspect of the gut–brain axis, we consider the hypothesis that the insular cortex plays an important role in determining the phenotype of ES mice as the insular cortex is a part of the upper central nervous system controlling digestive functions and is involved in the process of coping with psychological stress. Indeed, it was indicated in some rodent studies that psychological stress activates the insular cortex ( Nakatake et al, 2020 ; Zhang et al, 2022 ). Therefore, elucidating the functional mechanism underlying IBS-like symptoms in ES mice would substantially lead to understanding the “gut–brain axis.” Moreover, how different kinds of stress and individual differences affect intestinal functions is not well known both preclinically and clinically; therefore, creating an IBS-C animal model is keenly anticipated.…”

Section: Discussionmentioning

confidence: 99%

Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice

et al. 2022

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Increasing evidence has demonstrated that emotional states and intestinal conditions are inter-connected in so-called “brain–gut interactions.” Indeed, many psychiatric disorders are accompanied by gastrointestinal symptoms, such as the irritable bowel syndrome (IBS). However, the functional connection remains elusive, partly because there are few useful experimental animal models. Here, we focused on a highly validated animal model of stress-induced psychiatric disorders, such as depression, known as the chronic vicarious social defeat stress (cVSDS) model mice, which we prepared using exposure to repeated psychological stress, thereafter examining their intestinal conditions. In the charcoal meal test and the capsaicin-induced hyperalgesia test, cVSDS model mice showed a significantly higher intestinal transit ratio and increased visceral pain-related behaviors, respectively. These changes persisted over one month after the stress session. On the other hand, the pathological evaluations of the histological and inflammatory scores of naive and cVSDS model mice did not differ. Furthermore, keishikashakuyakuto—a kampo medicine clinically used for the treatment of IBS—normalized the intestinal motility change in cVSDS model mice. Our results indicate that cVSDS model mice present IBS-like symptoms such as chronic intestinal peristaltic changes and abdominal hyperalgesia without organic lesion. We therefore propose the cVSDS paradigm as a novel animal model of IBS with wide validity, elucidating the correlation between depressive states and intestinal abnormalities.

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“…The selective activation or inhibition of the insula→BLA pathway strengthens or weakens the intensity of observational pain, respectively. 126 …”

Section: Neural Correlates Of Prediction Errors In Pain Circuitsmentioning

confidence: 99%

Pain, from perception to action: A computational perspective

Chen¹,

Wang²

2023

iScience

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Glutamatergic synapses from the insular cortex to the basolateral amygdala encode observational pain

Cited by 64 publications

References 67 publications

Distinct basolateral amygdala excitatory inputs mediate the somatosensory and aversive-affective components of pain

Distinct basolateral amygdala excitatory inputs mediate the somatosensory and aversive-affective components of pain

Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice

Pain, from perception to action: A computational perspective

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