Glutamatergic pallidothalamic projections and their implications in the pathophysiology of Parkinson’s disease

Barroso‐Chinea, Pedro; Rico, Alberto J.; Pérez-Manso, Mónica; Roda, Elvira; López, Icíar P.; Luis-Ravelo, Diego; Lanciego, José L.

doi:10.1016/j.nbd.2008.05.019

Cited by 25 publications

(22 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The GABAergic inhibition is thought to modulate the excitatory positive feedback loop described above. The importance of dopamine and glutamate in this pathway has also been demonstrated [36], and inhibitory serotonergic projections from midbrain dorsal raphe nuclei to the striatum are also involved in this model [37,38].…”

Section: Circuit Modelsmentioning

confidence: 89%

Neuromodulation for Obsessive–Compulsive Disorder

et al. 2014

View full text Add to dashboard Cite

Neuromodulation shows increasing promise in the treatment of psychiatric disorders, particularly obsessivecompulsive disorder (OCD). Development of tools and techniques including deep brain stimulation, transcranial magnetic stimulation, and electroconvulsive therapy may yield additional options for patients who fail to respond to standard treatments. This article reviews the motivation for and use of these treatments in OCD. We begin with a brief description of the illness followed by discussion of the circuit models thought to underlie the disorder. These circuits provide targets for intervention. Basal ganglia and talamocortical pathophysiology, including cortico-striato-thalamo-cortical loops is a focus of this discussion. Neuroimaging findings and historical treatments that led to the use of neuromodulation for OCD are presented. We then present evidence from neuromodulation studies using deep brain stimulation, electroconvulsive therapy, and transcranial magnetic stimulation, with targets including nucleus accumbens, subthalamic nucleus inferior thalamic peduncle, dorsolateral prefrontal cortex, supplementary motor area, and orbitofrontal cortex. Finally, we explore potential future neuromodulation approaches that may further refine and improve treatment.

show abstract

Section: Circuit Modelsmentioning

confidence: 89%

Neuromodulation for Obsessive–Compulsive Disorder

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Based on current knowledge, ENT neurons projecting to PF are GABAergic and therefore, they express GABA precursors such as GAD65 and GAD67. Furthermore, it was recently suggested that a number of ENT efferent neurons also express glutamatergic markers (Barroso-Chinea et al, 2008b). This is exemplified in Fig.…”

Section: Resultsmentioning

confidence: 88%

Neuroanatomical tracing combined with in situ hybridization: Analysis of gene expression patterns within brain circuits of interest

Conte-Perales

Barroso‐Chinea

Rico

et al. 2010

Journal of Neuroscience Methods

Self Cite

View full text Add to dashboard Cite

“…Furthermore, neuronal vGlut2 mRNA expression has been found in the ENT nucleus (Hur and Zaborszky 2005;Geisler et al 2007;Barroso-Chinea et al 2008). Moreover, it has also been reported that basal ganglia output neurons innervating the ventral thalamus co-express GABA and ChAT (Kha et al 2000) as well as GABAergic and glutamatergic markers (Kha et al 2000;Barroso-Chinea et al 2008).…”

Section: Discussionmentioning

confidence: 96%

“…We have previously reported in the rat ENT nucleus that nigrostriatal lesion results in a down-regulation of vGlut expression levels concomitantly with the well-known increase of GAD65/67 mRNA . Apart from interspecies differences, this apparent discrepancy could be explained by the fact that, besides the ENT nucleus, the substantia nigra pars reticulate (SNr) is often regarded as the main basal ganglia output station in rodents and vGlut2 transcripts have never been detected at the level of the SNr ( Barroso-Chinea et al 2008). Moreover, here we are dealing with a bilateral dopaminergic denervation (systemic delivery of MPTP in monkeys) instead of the unilateral dopaminergic damage resulting from the intracerebral delivery of 6-OHDA.…”

Section: Changes In Gene Expression Patterns For Vgluts and Gads Mrnamentioning

confidence: 99%

“…These include cholinergic and glutamatergic neurons (Parent et al 1981;Kha et al 2000) as well as neurons containing different peptides (Murakami et al 1989a, b). Furthermore, GABAergic neurons within the entopeduncular nucleus (ENT, the rodent analog of the GPi nucleus in primates) are also known to express the mRNA coding isoform 2 of the vesicular glutamate transporter (vGlut2; Hur and Zaborszky 2005) and innervate the ventral thalamic motor nuclei (Kha et al 2000; Barroso-Chinea et al 2008), the caudal intralaminar nuclei ) as well as the ventral tegmental area (Geisler et al 2007). …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pallidothalamic-projecting neurons in Macaca fascicularis co-express GABAergic and glutamatergic markers as seen in control, MPTP-treated and dyskinetic monkeys

et al. 2011

Self Cite

View full text Add to dashboard Cite

GABAergic neurons within the internal division of the globus pallidus (GPi) are the main source of basal ganglia output reaching the thalamic ventral nuclei in monkeys. Following dopaminergic denervation, pallidothalamic-projecting neurons are known to be hyperactive, whereas a reduction in GPi activity is typically observed in lesioned animals showing levodopa-induced dyskinesia. Besides the mRNAs coding for GABAergic markers (GAD65 and GAD67), we show that all GPi neurons innervating thalamic targets also express transcripts for the isoforms 1 and 2 of the vesicular glutamate transporter (vGlut1 and vGlut2 mRNA). Indeed, dual immunofluorescent detection of GAD67 and vGlut1/2 confirmed the data gathered from in situ hybridization experiments, therefore demonstrating that the detected mRNAs are translated into the related proteins. Furthermore, the dopaminergic lesion resulted in an up-regulation of expression levels for both GAD65 and GAD67 mRNA within identified pallidothalamic-projecting neurons. This was coupled with a down-regulation of GAD65/67 mRNA expression levels in GPi neurons innervating thalamic targets in monkeys showing levodopa-induced dyskinesia. By contrast, the patterns of gene expression for both vGlut1 and vGlut2 mRNAs remained unchanged across GPi projection neurons in control, MPTP-treated and dyskinetic monkeys. In summary, both GABAergic and glutamatergic markers were co-expressed by GPi efferent neurons in primates. Although the status of the dopaminergic system directly modulates the expression levels of GAD65/67 mRNA, the observed expression of vGlut1/2 mRNA is not regulated by either dopaminergic removal or by continuous stimulation with dopaminergic agonists.

show abstract

Glutamatergic pallidothalamic projections and their implications in the pathophysiology of Parkinson’s disease

Cited by 25 publications

References 55 publications

Neuromodulation for Obsessive–Compulsive Disorder

Neuromodulation for Obsessive–Compulsive Disorder

Neuroanatomical tracing combined with in situ hybridization: Analysis of gene expression patterns within brain circuits of interest

Pallidothalamic-projecting neurons in Macaca fascicularis co-express GABAergic and glutamatergic markers as seen in control, MPTP-treated and dyskinetic monkeys

Contact Info

Product

Resources

About