Glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus can modulate haloperidol-induced catalepsy

Melo, Lauro; Santos, Paulo F.; Medeiros, Priscila; Mello, R.O.; Ferrari, E; Brandão, Marcus Lira; Maisonnette, Sílvia; Francisco, A.; Coimbra, Norberto Cysne

doi:10.1016/j.brainres.2010.06.020

Cited by 39 publications

(27 citation statements)

References 54 publications

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“…SCH-23390 and haloperidol, which decreased activity in the present study, have also been shown to decrease activity in rodents (Morato et al, 1989, Beninger et al, 1991, Choi et al, 2009), and haloperidol has been reported to cause a sedative effect in humans (King et al, 1995). Further, the nonselective and D2-like receptor antagonists tested in the present study abolished larval locomotion at high doses, which is consistent with reports of increased catatonia observed in rotarod tests in rats (Morato et al, 1989, Melo et al, 2010). These findings also suggest the induction of similar actions in mammals and zebrafish caused by dopamine receptor drugs.…”

Section: Discussionsupporting

confidence: 92%

Acute administration of dopaminergic drugs has differential effects on locomotion in larval zebrafish

Irons

Kelly

Hunter

et al. 2013

Pharmacology Biochemistry and Behavior

144

129

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Altered dopaminergic signaling causes behavioral changes in mammals. In general, dopaminergic receptor agonists increase locomotor activity, while antagonists decrease locomotor activity. In order to determine if zebrafish (a model organism becoming popular in pharmacology and toxicology) respond similarly, the acute effects of drugs known to target dopaminergic receptors in mammals were assessed in zebrafish larvae. Larvae were maintained in 96-well microtiter plates (1 larva/well). Non-lethal concentrations (0.2–50 µM) of dopaminergic agonists (apomorphine, SKF-38393, and quinpirole) and antagonists (butaclamol, SCH-23390, and haloperidol) were administered at 6 days post-fertilization (dpf). An initial experiment identified the time of peak effect of each drug (20–260 minutes post-dosing, depending on the drug). Locomotor activity was then assessed for 70 minutes in alternating light and dark at the time of peak effect for each drug to delineate dose-dependent effects. All drugs altered larval locomotion in a dose-dependent manner. Both the D1- and D2-like selective agonists (SKF-38393 and quinpirole, respectively) increased activity, while the selective antagonists (SCH-23390 and haloperidol, respectively) decreased activity. Both selective antagonists also blunted the response of the larvae to changes in lighting conditions at higher doses. The nonselective drugs had biphasic effects on locomotor activity: apomorphine increased activity at the low dose and at high doses, while butaclamol increased activity at low to intermediate doses, and decreased activity at high doses. This study demonstrates that (1) larval zebrafish locomotion can be altered by dopamine receptor agonists and antagonists, (2) receptor agonists and antagonists generally have opposite effects, and (3) drugs that target dopaminergic receptors in mammals appear, in general, to elicit similar locomotor responses in zebrafish larvae.

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Section: Discussionsupporting

confidence: 92%

Acute administration of dopaminergic drugs has differential effects on locomotion in larval zebrafish

Irons

Kelly

Hunter

et al. 2013

Pharmacology Biochemistry and Behavior

144

129

View full text Add to dashboard Cite

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“…Although DA-mediated mechanisms that are involved in the generation of aversion at the level of the IC have not been extensively studied, this region has appreciable dopaminergic activity [52], [53]. In the present study, intra-IC injections of sulpiride exerted clear anxiogenic-like effects in rats subjected to the EPM and enhanced the amplitude of AEPs in response to loud auditory stimuli recorded from the ventral aspects of the IC.…”

Section: Discussionmentioning

confidence: 49%

Dopamine D2-Like Receptors Modulate Unconditioned Fear: Role of the Inferior Colliculus

et al. 2014

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BackgroundA reduction of dopamine release or D2 receptor blockade in the terminal fields of the mesolimbic system clearly reduces conditioned fear. Injections of haloperidol, a preferential D2 receptor antagonist, into the inferior colliculus (IC) enhance the processing of unconditioned aversive information. However, a clear characterization of the interplay of D2 receptors in the mediation of unconditioned and conditioned fear is still lacking.MethodsThe present study investigated the effects of intra-IC injections of the D2 receptor-selective antagonist sulpiride on behavior in the elevated plus maze (EPM), auditory-evoked potentials (AEPs) to loud sounds recorded from the IC, fear-potentiated startle (FPS), and conditioned freezing.ResultsIntra-IC injections of sulpiride caused clear proaversive effects in the EPM and enhanced AEPs induced by loud auditory stimuli. Intra-IC sulpiride administration did not affect FPS or conditioned freezing.ConclusionsDopamine D2-like receptors of the inferior colliculus play a role in the modulation of unconditioned aversive information but not in the fear-potentiated startle response.

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“…Noradrenergic activation as part of the fight‐or‐flight response to aversive stimuli remains a candidate mechanism and is supported by studies showing that animals treated with haloperidol are able to overcome their motor difficulties during a stressful situation, during which they also develop high plasma levels of noradrenaline (Yntema & Korf, 1987). In addition, glutamatergic mechanisms in the inferior colliculus, a structure which has been demonstrated to process auditory information and send output to motor centres which induce defensive behaviors such as arousal and escape responses (Melo et al. , 2010), may play a role.…”

Section: Discussionmentioning

confidence: 99%

Improvements in rate of development and magnitude of force with intense auditory stimuli in patients with Parkinson’s disease

Anzak

Tan

Pogosyan

et al. 2011

European Journal of Neuroscience

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Patients with Parkinson's disease can show brief but dramatic normalization of motor activity in highly arousing situations, a phenomenon often termed paradoxical kinesis. We sought to mimic this in a controlled experimental environment. Nine patients with Parkinson's disease and nine age-matched healthy controls were asked to grip a force dynamometer as quickly and strongly as possible in response to a visual cue. A loud (96 dB) auditory stimulus was delivered at the same time as the visual cue in ~50% of randomly selected trials. In patients with Parkinson's disease, the experiment was conducted after overnight withdrawal of antiparkinsonian drugs and again 1 h after patients had taken their usual morning medication. Patients showed improvements in the peak rate of force development and the magnitude of force developed when loud auditory stimuli accompanied visual cues. Equally, they showed improvements in the times taken to reach the peak rate of force development and their maximal force. The paradoxical facilitatory effect of sound was similar whether patients were off or on their usual antiparkinsonian medication, and could be reproduced in age-matched healthy controls. We conclude that motor improvement induced by loud auditory stimuli in Parkinson's disease is related to a physiological phenomenon which survives both with and after withdrawal of antiparkinsonian medication. The potential independence of the mediating pathways from the dopaminergic system provides impetus for further investigation as it may yield a novel nondopaminergic target for therapeutic manipulation in Parkinson's disease.

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Glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus can modulate haloperidol-induced catalepsy

Cited by 39 publications

References 54 publications

Acute administration of dopaminergic drugs has differential effects on locomotion in larval zebrafish

Acute administration of dopaminergic drugs has differential effects on locomotion in larval zebrafish

Dopamine D2-Like Receptors Modulate Unconditioned Fear: Role of the Inferior Colliculus

Improvements in rate of development and magnitude of force with intense auditory stimuli in patients with Parkinson’s disease

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