Glutamatergic neuron types in the amygdala of the urodele amphibian Pleurodeles waltl

Deryckere, Astrid; Woych, Jamie; Jaeger, Eliza C.B.; Tosches, Maria Antonietta

doi:10.1101/2022.06.15.496313

Cited by 4 publications

(3 citation statements)

References 78 publications

(172 reference statements)

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“…For example, we found co-clustering of salamander MP and the reptilian medial cortex and of salamander LP and the reptilian lateral cortex. The salamander pallial amygdala ( 23 ) and reptilian posterior DVR (pDVR), putative homologs of the mammalian pallial amygdala ( 36 ), also co-clustered (Fig. 4D and fig.…”

Section: Resultsmentioning

confidence: 95%

“…Subdivisions of VP include a Nos1-negative anterior VP (VPa) and a Nos1 + posterior VP (VPp) [see also (16)]. Along the anterior-posterior axis, Slc17a6 is expressed only in the most ventral portion of the VP, suggesting the existence of further diversity along the mediolateral axis; Slc17a6 is expressed at higher levels in the adjacent amygdala, as described in (23) (figs. S6 to S8 and movies S2 and S3).…”

Section: Spatial Distribution Of Pallial Glutamatergic Neuronsmentioning

confidence: 99%

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Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution

Woych

Gurrola

Deryckere

et al. 2022

Science

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The evolution of advanced cognition in vertebrates is associated with two independent innovations in the forebrain: the six-layered neocortex in mammals and the dorsal ventricular ridge (DVR) in sauropsids (reptiles and birds). How these innovations arose in vertebrate ancestors remains unclear. To reconstruct forebrain evolution in tetrapods, we built a cell-type atlas of the telencephalon of the salamander Pleurodeles waltl . Our molecular, developmental, and connectivity data indicate that parts of the sauropsid DVR trace back to tetrapod ancestors. By contrast, the salamander dorsal pallium is devoid of cellular and molecular characteristics of the mammalian neocortex yet shares similarities with the entorhinal cortex and subiculum. Our findings chart the series of innovations that resulted in the emergence of the mammalian six-layered neocortex and the sauropsid DVR.

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Section: Resultsmentioning

confidence: 95%

Section: Spatial Distribution Of Pallial Glutamatergic Neuronsmentioning

confidence: 99%

Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution

Woych

Gurrola

Deryckere

et al. 2022

Science

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“…NLOT is evolutionarily conserved and can be found in both mammalian and non-mammalian species (Turner et al, 1978; Deryckere et al, 2022; Metwalli et al, 2022). In mammalians, it is more prominent in macrosmatic species (Crosby and Schnitzlein, 1982), supporting the notion that it plays an important role in odor-guided behaviors.…”

Section: Introductionmentioning

confidence: 99%

Synaptic connectivity and electrophysiological properties of the nucleus of the lateral olfactory tract

Penker,

Lawabny,

Dhamshy

et al. 2024

Preprint

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The sense of smell is tightly linked to emotions, a link that is thought to rely on the direct synaptic connections between the olfactory bulb and nuclei of the amygdala. A small number of amygdaloid nuclei are the recipients of such direct input from the olfactory bulb and their unique functions are not known. Among them, the nucleus of the lateral olfactory tract (NLOT) is unique in its developmental history and gene expression. NLOT has been very little studied and consequentially its function is unknown. Furthermore, formulation of informed hypotheses about NLOT function is at this stage limited by the lack of knowledge about its connectivity and physiological properties. Here, we used pseudo-rabies tracing methods to systematically reveal monosynaptic inputs into NLOT, and adeno-associated viruses to reveal NLOT projection targets. We found that the NLOT is interconnected with several olfactory brain regions and with the basolateral amygdala. Some of these connections were reciprocal, and some showed unique interhemispheric patterns. We tested the excitable properties of NLOT neurons and the properties of each of the major synaptic inputs. We found that the NLOT receives powerful input from piriform cortex, tenia tecta, and the basolateral amygdala, but only very weak input from the olfactory bulb. When input crosses threshold, NLOT neurons respond with calcium-dependent bursts of action potentials. This integration of olfactory and amygdalar inputs suggests that NLOT plays a role in behaviors that combine smell and emotion, possibly assigning emotional value to odors.

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Evolution and Development of Amygdala Subdivisions: Pallial, Subpallial, and Beyond

et al. 2022

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The amygdala is a central node in functional networks regulating emotions, social behavior and social cognition. It develops in the telencephalon and includes pallial and subpallial parts, but these are extremely complex with multiple subdivisions, cell types and connections. The homology of the amygdala in non-mammals is highly controversial, especially for the pallial part, and we are still far from understanding general principles on its organization that are common to different groups. Here we review data on the adult functional architecture and developmental genoarchitecture of the amygdala in different amniotes (mammals and sauropsids), which are helping to disentangle and to better understand this complex structure. The use of an evolutionary developmental biology (evodevo) approach has helped to distinguish three major divisions in the amygdala, derived from the pallium, the subpallium and from a newly identified division called telencephalon-opto-hypothalamic domain (TOH). This approach has also helped to identify homologous cell populations with identical embryonic origins and molecular profiles in the amygdala of different amniotes. While subpallial cells produce different subtypes of GABAergic neurons, the pallium and TOH are major sources of glutamatergic cells. Available data point to a development-based molecular code that contributes to shape distinct functional subsystems in the amygdala, and comparative genoarchitecture is helping to delineate the cells involved in same subsystems in non-mammals. Thus, the evodevo approach can provide crucial information to understand common organizing principles of the amygdalar cells and networks that control behavior, emotions and cognition in amniotes.

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Glutamatergic neuron types in the amygdala of the urodele amphibian Pleurodeles waltl

Cited by 4 publications

References 78 publications

Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution

Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution

Synaptic connectivity and electrophysiological properties of the nucleus of the lateral olfactory tract

Evolution and Development of Amygdala Subdivisions: Pallial, Subpallial, and Beyond

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