Glutamatergic activation of anterior cingulate cortex mediates the affective component of visceral pain memory in rats

Ni, Yaodong; Cao, Bing; Xu, Jiahe; Hu, Chun; Zhang, Xu; Li, Ying

doi:10.1016/j.nlm.2011.11.003

Cited by 52 publications

(59 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar results have been found for the NMDAR ligand glutamate (Johansen and Fields, 2004). Other studies have supported this idea that increased glutamate signaling in the ACC is an important aspect of the persistence of many pain states (Wu et al, 2008; Yan et al, 2012; Zhou et al, 2014). LaGraize and Fuchs (2007) identified an important role of the ACC GABA system in modulating the affective component of pain.…”

Section: Additional Considerationsmentioning

confidence: 80%

The anterior cingulate cortex and pain processing

Fuchs

Peng

Boyette-Davis

et al. 2014

Front. Integr. Neurosci.

210

121

View full text Add to dashboard Cite

The neural network that contributes to the suffering which accompanies persistent pain states involves a number of brain regions. Of primary interest is the contribution of the cingulate cortex in processing the affective component of pain. The purpose of this review is to summarize recent data obtained using novel behavioral paradigms in animals based on measuring escape and/or avoidance of a noxious stimulus. These paradigms have successfully been used to study the nature of the neuroanatomical and neurochemical contributions of the anterior cingulate cortex (ACC) to higher order pain processing in rodents.

show abstract

Section: Additional Considerationsmentioning

confidence: 80%

The anterior cingulate cortex and pain processing

Fuchs

Peng

Boyette-Davis

et al. 2014

Front. Integr. Neurosci.

210

121

View full text Add to dashboard Cite

show abstract

“…In recent years, the neuroimaging of humans showed that in patients with IBS, the functional activity of the brain plays an important role in the response to visceral stimulation and reflects the severity of the IBS symptoms. As an important center of pain, the anterior cingulate cortex has extensive fiber links with the medial thalamus medulla, amygdala, periaqueductal gray matter, caudate nucleus, and other nuclei involved in the modulation of pain sensation [38][39][40]. Positron emission tomography (PET) showed that the cingulate cortex in patients with IBS was activated after CRD [41].…”

Section: Discussionmentioning

confidence: 99%

Effect of electroacupuncture on P2X3 receptor regulation in the peripheral and central nervous systems of rats with visceral pain caused by irritable bowel syndrome

Weng

Wu²,

Zhou

et al. 2015

Purinergic Signalling

View full text Add to dashboard Cite

The aim of this study is to investigate the role of the purinergic receptor P2X 3 in the peripheral and central nervous systems during acupuncture treatment for the visceral pain of irritable bowel syndrome (IBS). A total of 24 8-day-old Sprague-Dawley (SD) neonatal male rats (SPF grade) were stimulated using colorectal distention (CRD) when the rats were awake. The modeling lasted for 2 weeks with one stimulation per day. After 6 weeks, the rats were randomly divided into three groups of eight each: (1) the normal group (NG, n= 8); (2) the model group (MG, n=8); and (3) the model+ electroacupuncture group (EA, n = 8) that received electroacupuncture at a needling depth of 5 mm at the Shangjuxu (ST37, bilateral) and Tianshu (ST25, bilateral) acupoints. The parameters of the Han's acupoint nerve stimulator (HANS) were as follows: sparse-dense wave with a frequency of 2/100 Hz, current of 2 mA, 20 min/stimulation, and one stimulation per day; the treatment was provided for seven consecutive days. At the sixth week after the treatment, the abdominal withdrawal reflex (AWR) score was determined; immunofluorescence and immunohistochemistry were used to measure the expression of the P2X 3 receptor in myenteric plexus neurons, prefrontal cortex, and anterior cingulate cortex; and, a real-time PCR assay was performed to measure the expression of P2X 3 messenger RNA (mRNA) in the dorsal root ganglion (DRG) and spinal cord. After stimulation with CRD, the expression levels of the P2X 3 receptor in the intercolonic myenteric plexus, DRG, spinal cord, prefrontal cortex, and anterior cingulate cortex were upregulated, and the sensitivity of the rats to IBS visceral pain was increased. Electroacupuncture (EA) could downregulate the expression of the P2X 3 receptor and ease the sensitivity to visceral pain. The P2X 3 receptor plays an important role in IBS visceral pain. The different levels of P2X 3 in the peripheral enteric nervous system and central nervous system mediate the effects of the EA treatment of the visceral hyperalgesia of IBS.

show abstract

“…The ACG is a multifunctional region that participates in information processing of visceral sensory data, cognitive control and emotional arousal. [35][36][37][38] It is one of the most commonly activated areas during visceral distension. 39,40 Intriguingly, the nodal centralities in the ACG were found to be positively related to DSS of patients in the current results, which reflected the correlation between information flow through the ACG and symptom severity.…”

Section: Discussionmentioning

confidence: 99%

Topological Alterations of the Intrinsic Brain Network in Patients with Functional Dyspepsia

Nan

Zhang

Zhu

et al. 2015

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Background/AimsPrevious studies reported that integrated information in the brain ultimately determines the subjective experience of patients with chronic pain, but how the information is integrated in the brain connectome of functional dyspepsia (FD) patients remains largely unclear. The study aimed to quantify the topological changes of the brain network in FD patients. MethodsSmall-world properties, network efficiency and nodal centrality were utilized to measure the changes in topological architecture in 25 FD patients and 25 healthy controls based on functional magnetic resonance imaging. Pearson's correlation assessed the relationship of each topological property with clinical symptoms. ResultsFD patients showed an increase of clustering coefficients and local efficiency relative to controls from the perspective of a whole network as well as elevated nodal centrality in the right orbital part of the inferior frontal gyrus, left anterior cingulate gyrus and left hippocampus, and decreased nodal centrality in the right posterior cingulate gyrus, left cuneus, right putamen, left middle occipital gyrus and right inferior occipital gyrus. Moreover, the centrality in the anterior cingulate gyrus was significantly associated with symptom severity and duration in FD patients. Nevertheless, the inclusion of anxiety and depression scores as covariates erased the group differences in nodal centralities in the orbital part of the inferior frontal gyrus and hippocampus. ConclusionsThe results suggest topological disruption of the functional brain networks in FD patients, presumably in response to disturbances of sensory information integrated with emotion, memory, pain modulation, and selective attention in patients. (J Neurogastroenterol Motil 2016;22:118-128)

show abstract

Glutamatergic activation of anterior cingulate cortex mediates the affective component of visceral pain memory in rats

Cited by 52 publications

References 29 publications

The anterior cingulate cortex and pain processing

The anterior cingulate cortex and pain processing

Effect of electroacupuncture on P2X3 receptor regulation in the peripheral and central nervous systems of rats with visceral pain caused by irritable bowel syndrome

Topological Alterations of the Intrinsic Brain Network in Patients with Functional Dyspepsia

Contact Info

Product

Resources

About