Glutamate Signaling and Filopodiagenesis of Astrocytoma Cells in Brain Cancers: Survey and Questions

Tabatabaee, Mitra Sadat; Ménard, Fréderic

doi:10.3390/cells11172657

Cited by 2 publications

(3 citation statements)

References 104 publications

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“…Astrocytes, long regarded as supportive cells, are now recognized for their active involvement in CNS-microbiome communication [18,[62][63][64]. Astrocytes are intimately involved in regulating synaptic function and plasticity.…”

Section: Astrocytes: Orchestrators Of Homeostasismentioning

confidence: 99%

“…It is conceivable that, upon detecting bacterial metabolites, astrocytes could regulate neurotransmitter levels in the extracellular space and, consequently, regulate neural networks. For instance, it is known that astrocytes uptake the excessive accumulated glutamate from the synaptic cleft via glutamate transporters [64,67,68]. Glutamate is the main excitatory neurotransmitter in our central nervous system [2,69,70].…”

Section: Astrocytes: Orchestrators Of Homeostasismentioning

confidence: 99%

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Microbiome-Glia Crosstalk: Bridging the Communication Divide in the Central Nervous System

Tabatabaee

2024

Neuroglia

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The traditional neuron-centric view of the central nervous system (CNS) is shifting toward recognizing the importance of communication between the neurons and the network of glial cells. This shift is leading to a more comprehensive understanding of how glial cells contribute to CNS function. Alongside this shift, recent discoveries have illuminated the significant role of the human microbiome, comprising trillions of microorganisms, mirroring the number of human cells in an individual. This paper delves into the multifaceted functions of neuroglia, or glial cells, which extend far beyond their traditional roles of supporting and protecting neurons. Neuroglia modulate synaptic activity, insulate axons, support neurogenesis and synaptic plasticity, respond to injury and inflammation, and engage in phagocytosis. Meanwhile, the microbiome, long overlooked, emerges as a crucial player in brain functionality akin to glial cells. This review aims to underscore the importance of the interaction between glial cells and resident microorganisms in shaping the development and function of the human brain, a concept that has been less studied. Through a comprehensive examination of existing literature, we discuss the mechanisms by which glial cells interface with the microbiome, offering insights into the contribution of this relationship to neural homeostasis and health. Furthermore, we discuss the implications of dysbiosis within this interaction, highlighting its potential contribution to neurological disorders and paving the way for novel therapeutic interventions targeting both glial cells and the microbiome.

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Section: Astrocytes: Orchestrators Of Homeostasismentioning

confidence: 99%

Section: Astrocytes: Orchestrators Of Homeostasismentioning

confidence: 99%

Microbiome-Glia Crosstalk: Bridging the Communication Divide in the Central Nervous System

Tabatabaee

2024

Neuroglia

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“…Historically, astrocytes have been marked as non-excitable but recent research has unveiled their role in cell signaling through response to glutamate [ 45 ]. The use of ligand-gated channels such as ionotropic glutamate receptors allows astrocytes to respond to intracellular fluctuations in calcium [ 46 , 47 ]. They also have various ligand-gated calcium channels, which are known to be fundamental to CNS function.…”

Section: Cells Involved In Glioma Pathogenesismentioning

confidence: 99%

Ligand-Gated Ion Channels: Prognostic and Therapeutic Implications for Gliomas

Hey

Rao

Carter

et al. 2023

JPM

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Gliomas are common primary brain malignancies that remain difficult to treat due to their overall aggressiveness and heterogeneity. Although a variety of therapeutic strategies have been employed for the treatment of gliomas, there is increasing evidence that suggests ligand-gated ion channels (LGICs) can serve as a valuable biomarker and diagnostic tool in the pathogenesis of gliomas. Various LGICs, including P2X, SYT16, and PANX2, have the potential to become altered in the pathogenesis of glioma, which can disrupt the homeostatic activity of neurons, microglia, and astrocytes, further exacerbating the symptoms and progression of glioma. Consequently, LGICs, including purinoceptors, glutamate-gated receptors, and Cys-loop receptors, have been targeted in clinical trials for their potential therapeutic benefit in the diagnosis and treatment of gliomas. In this review, we discuss the role of LGICs in the pathogenesis of glioma, including genetic factors and the effect of altered LGIC activity on the biological functioning of neuronal cells. Additionally, we discuss current and emerging investigations regarding the use of LGICs as a clinical target and potential therapeutic for gliomas.

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Glutamate Signaling and Filopodiagenesis of Astrocytoma Cells in Brain Cancers: Survey and Questions

Cited by 2 publications

References 104 publications

Microbiome-Glia Crosstalk: Bridging the Communication Divide in the Central Nervous System

Microbiome-Glia Crosstalk: Bridging the Communication Divide in the Central Nervous System

Ligand-Gated Ion Channels: Prognostic and Therapeutic Implications for Gliomas

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