Glutamate receptor antagonism in inferior colliculus attenuates elevated startle response of high anxiety diazepam-withdrawn rats

Cabral, Alícia; Ross, Jas; Castilho, V.M.; Brandão, ML; Nobre, Manoel Jorge

doi:10.1016/j.neuroscience.2009.03.073

Cited by 12 publications

(5 citation statements)

References 49 publications

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“…This method of analysis is similar to previous studies from our and other laboratories [16], [29]–[31]. Peak amplitudes were defined as the maximum amplitude measured between N1 and the end of P1, similar to previous studies from our laboratory [7], [27], [31]. The computer output was graphically displayed on an XY plotter (Hewlett-Packard, Palo Alto, CA, USA).…”

Section: Methodsmentioning

confidence: 91%

Dopamine D2-Like Receptors Modulate Unconditioned Fear: Role of the Inferior Colliculus

et al. 2014

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BackgroundA reduction of dopamine release or D2 receptor blockade in the terminal fields of the mesolimbic system clearly reduces conditioned fear. Injections of haloperidol, a preferential D2 receptor antagonist, into the inferior colliculus (IC) enhance the processing of unconditioned aversive information. However, a clear characterization of the interplay of D2 receptors in the mediation of unconditioned and conditioned fear is still lacking.MethodsThe present study investigated the effects of intra-IC injections of the D2 receptor-selective antagonist sulpiride on behavior in the elevated plus maze (EPM), auditory-evoked potentials (AEPs) to loud sounds recorded from the IC, fear-potentiated startle (FPS), and conditioned freezing.ResultsIntra-IC injections of sulpiride caused clear proaversive effects in the EPM and enhanced AEPs induced by loud auditory stimuli. Intra-IC sulpiride administration did not affect FPS or conditioned freezing.ConclusionsDopamine D2-like receptors of the inferior colliculus play a role in the modulation of unconditioned aversive information but not in the fear-potentiated startle response.

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Section: Methodsmentioning

confidence: 91%

Dopamine D2-Like Receptors Modulate Unconditioned Fear: Role of the Inferior Colliculus

et al. 2014

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“…Although different from selective breeding to create convergent genetic lines of animals, which selects rats based on the extremes of a population, the present procedure selects rats simply by their reactivity in the contextual fear conditioning paradigm. Our laboratory and others have reported that animal models of anxiety are able to select rats for various aspects of physiology and behavior, particularly with higher or lower degrees of anxiety-related behavior (Cabral et al, 2009;Borta et al, 2006;Ponder et al, 2007Ponder et al, , 2008Salomé et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Influence of age on reactivity to diverse emotional challenges in low‐ and high‐anxiety rats

Oliveira

Gomes

Brandão

2010

Intl J of Devlp Neuroscience

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Studies have revealed that the extent of reactivity of high-anxiety rats to diverse challenges is different than low-anxiety rats and have provided important insights into the psychopathology of anxiety. Various factors intervene to allow defensive mechanisms to react to diverse threatening challenges, including ontogeny and the nature of the emotional challenge (e.g., conditioned vs. unconditioned). The present study investigated the extent to which a particular type of fear extrapolates to other emotional responses to diverse threatening challenges. Groups of 30- and 60-day-old rats were assigned to low freezing behavior (LFB) and high freezing behavior (HFB) groups using the contextual fear conditioning paradigm and subjected to either the fear-potentiated startle (FPS) test, novelty-induced ultrasound vocalizations (USVs) or elevated plus-maze (EPM) tests. At 30 days of age, HFB rats exhibited greater FPS than LFB rats. In contrast, prior selection of HFB and LFB did not affect the performance of 30-day-old animals in the EPM and novelty-induced USVs. Sixty-day-old animals exhibited a performance deficit in all three tests. These data suggest that the performance of young rats in animal models of anxiety parallels their selection as LFB and HFB in the contextual fear conditioning paradigm. However, the increased fear-like behavior exhibited by the 60-day-old HFB rats may elicit performance deficits in conditioned and unconditioned fear tests. These results suggest that the interaction between hyperanxiety and age may cause a performance deficit despite the animals' increased fear-like behavior when facing emotional challenges, thus resembling psychiatric patients in many respects.

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“…20 Serotonin antagonists also decrease startle rates. 21 Although glutamate antagonism in the inferior colliculus attenuated hyperactive startle response in rats, 22 studies with NMDA ( N -methyl- d -aspartate) antagonist such as memantine did not change startle magnitude in humans. 23,24 Hence, decreased ASR rates and increased latencies of ASRs and SSSs in our study may be attributed to dopaminergic or serotoninergic antagonism or GABA agonistic effect.…”

Section: Discussionmentioning

confidence: 98%

Does Valproic Acid/Na Valproate Suppress Auditory Startle Reflex in Patients With Epilepsy?

et al. 2017

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Glutamate receptor antagonism in inferior colliculus attenuates elevated startle response of high anxiety diazepam-withdrawn rats

Cited by 12 publications

References 49 publications

Dopamine D2-Like Receptors Modulate Unconditioned Fear: Role of the Inferior Colliculus

Dopamine D2-Like Receptors Modulate Unconditioned Fear: Role of the Inferior Colliculus

Influence of age on reactivity to diverse emotional challenges in low‐ and high‐anxiety rats

Does Valproic Acid/Na Valproate Suppress Auditory Startle Reflex in Patients With Epilepsy?

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