Glutamate inputs send prediction error of reward but not negative value of aversive stimuli to dopamine neurons
Ryunosuke Amo,
Naoshige Uchida,
Mitsuko Watabe-Uchida
Abstract:SummaryMidbrain dopamine neurons are thought to signal reward prediction errors (RPEs) but the mechanisms underlying RPE computation, particularly contributions of different neurotransmitters, remain poorly understood. Here we used a genetically-encoded glutamate sensor to examine the pattern of glutamate inputs to dopamine neurons. We found that glutamate inputs exhibit virtually all of the characteristics of RPE, rather than conveying a specific component of RPE computation such as reward or expectation. Not… Show more
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