Glutamate-induced retinal lipid and protein damage: The protective effects of catechin

A Two-Year, Double-Blind, Randomized Placebo-Controlled Trial of Oral Green Tea Polyphenols on the Long-Term Clinical and Histologic Appearance of Photoaging Skin

“…Regarding the serious adverse event of retinal detachment in a patient supplemented with green tea, our search of the medical literature did not reveal any association with retinal detachment. In contrast, there are recent reports of green tea polyphenols decreasing reperfusion injury in rat retinal neurons, 45,46 and it can be protective of cellular toxicity of the retina in vitro 47 . There are no reports in the medical literature linking green tea ingestion with appendicitis.…”

Green Tea Is Neuroprotective in Diabetic Retinopathy

“…Treatment with taurine, a retinal amino acid, prevented degradation under diabetic conditions by exerting antioxidant effects. Studies by Siu et al 50 involving mass spectrometry have shown that in retinal homogenates, treatment with glutamate induced lipid peroxidation. The presence of catechin, a polyphenol present in GT, significantly reversed the changes in levels of thioredoxin peroxidase, 5-hydroxytryptamine receptor, peroxiredoxin 6, and pyruvate, thus protecting the retinal tissue from glutamateinduced lipoperoxidation.…”

Differential Proteomics and Functional Research following Gene Therapy in a Mouse Model of Leber Congenital Amaurosis

“…Finally, in this set of proteins, there is a lack of information about the role of peroxiredoxin-6 (PRDX6) in RDD. However, it has been demonstrated that PRDX6 is involved in glutamate-induced retinal toxicity [41], [42] and protects against hypoxia-induced retinal ganglion cell damage [43]. Thus, the detailed investigation of PRDX6 was considered important and this protein was also selected for additional tests.…”