Glutamate in the inferior colliculus plays a critical role in audiogenic seizure initiation

Faingold, Carl L.; a, Dean K. Naritoku; Copley, Cathy A.; Randall, Marcus E.; Riaz, Awais; Anderson, Cathy A.Boersma; Arnerić, Stephen P.

doi:10.1016/0920-1211(92)90064-z

Cited by 70 publications

(17 citation statements)

References 39 publications

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“…Excessive excitatory transmission may also char- acterize other models of seizure proclivity with similarities to metaphit. A role for the NMDAIPCP complex has been documented in brainstem seizures of genetic models of the epilepsies (Chapman and Meldrum, 1989;Faingold et al, 1992) and in kindling (Freeman et al, 1982;Glibert, 1988;Leander et al, 1988;McNamara et al, 1988;Morimoto and Sato, 1992). This proposed commonality in excessive excitatory transmission by the NMDA/PCP receptor complex may be responsible for the similar pharmacologic profiles that characterize some of the effects of metaphit and NMDA.…”

Section: Epilepsiamentioning

confidence: 99%

Facilitation of Amygdala Kindling Development and Kindled Seizures by Metaphit

et al. 1994

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The effect of metaphit (a phencyclidine analogue with an acylating isothiocyanate) on kindling development and kindled seizures from amygdala was investigated in rats pretreated once with metaphit. Administration of a single dose of metaphit (10 or 20 mg/kg intraperitoneally i.p.) 4 h before the first electrical stimulation of the amygdala did not in itself induce seizures, but greatly facilitated development of behavioral seizures during kindling. This effect persisted throughout the whole process of electrical amygdala kindling without further dosing. In contrast, metaphit only transiently and modestly increased the growth of afterdischarge (AD) duration. In kindled rats, pretreatment with a single dose of metaphit (20 mg/kg) 8 h before the test stimulation reduced the threshold current required to elicit a stage 5 seizure and shortened the latency for bilateral forelimb clonus (BFC) without changing AD duration or BFC duration. The facilitation of kindling development and kindled seizures may be due to an excessive excitatory transmission by metaphit in the limbic seizure circuitry.

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Section: Epilepsiamentioning

confidence: 99%

Facilitation of Amygdala Kindling Development and Kindled Seizures by Metaphit

et al. 1994

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“…TRPV1 channel is a nonselective cation channel with high Ca 2+ permeability, and its activation results in increased intracellular Ca 2+ and neuronal excitability, leading to enhanced glutamate release . Interestingly, altered intracellular Ca 2+ and glutamate signaling in the IC are known to play important roles in the pathophysiology of seizures in GEPRs . Whether Ca 2+ signaling via TRPV1 channels interacting with glutamate signaling is critical in AGS susceptibility in GEPR‐3s remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…[23][24][25][26] Interestingly, altered intracellular Ca 2+ and glutamate signaling in the IC are known to play important roles in the pathophysiology of seizures in GEPRs. 27,28 Whether Ca 2+ signaling via TRPV1 channels interacting with glutamate signaling is critical in AGS susceptibility in GEPR-3s remains unknown. Another putative mechanism underlying epileptogenesis is long-term potentiation (LTP), where repeated synaptic stimulation lead to enhancement of synaptic efficiency.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of transient potential receptor vanilloid type 1 suppresses seizure susceptibility in the genetically epilepsy‐prone rat

et al. 2017

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“…Similarly, administration of AMPA alone increased the frequency of SWD [73], but co-administration of an NMDA receptor-antagonist was sufficient to block this increase. In GEPRs, inhibition of glutamate synthesis, NMDA, or AMPA receptors attenuated seizure severity [74]. Contrary to the pilocarpine-SE model, where decreases in mGluR 2/3 activation increased with seizure sensitivity, mGluR 2/3 antagonists decreased seizure frequency in Wag/Rij rats [75].…”

Section: Potential Mechanisms and Therapeutic Targetsmentioning

confidence: 99%

Rhythm and blues: Animal models of epilepsy and depression comorbidity

Epps

Weinshenker

2013

Biochemical Pharmacology

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Clinical evidence shows a strong, bidirectional comorbidity between depression and epilepsy that is associated with decreased quality of life and responsivity to pharmacotherapies. At present, the neurobiological underpinnings of this comorbidity remain hazy. To complicate matters, anticonvulsant drugs can cause mood disturbances, while antidepressant drugs can lower seizure threshold, making it difficult to treat patients suffering from both depression and epilepsy. Animal models have been created to untangle the mechanisms behind the relationship between these disorders and to serve as screening tools for new therapies targeted to treat both simultaneously. These animal models are based on chemical interventions (e.g. pentylenetetrazol, kainic acid, pilocarpine), electrical stimulations (e.g. kindling, electroshock), and genetic/selective breeding paradigms (e.g. Genetically Epilepsy-Prone Rats (GEPRs), Genetic Absence Epilepsy Rat from Strasbourg (GAERS), WAG/Rij rats, Swim Lo-Active rats (SwLo)). Studies on these animal models point to some potential mechanisms that could explain epilepsy and depression comorbidity, such as various components of the dopaminergic, noradrenergic, serotonergic, and GABAergic systems, as well as key brain regions, like the amygdala and hippocampus. These models have also been used to screen possible therapies. The purpose of the present review is to highlight the importance of animal models in research on comorbid epilepsy and depression and to explore the contributions of these models to our understanding of the mechanisms and potential treatments for these disorders.

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Glutamate in the inferior colliculus plays a critical role in audiogenic seizure initiation

Cited by 70 publications

References 39 publications

Facilitation of Amygdala Kindling Development and Kindled Seizures by Metaphit

Facilitation of Amygdala Kindling Development and Kindled Seizures by Metaphit

Inhibition of transient potential receptor vanilloid type 1 suppresses seizure susceptibility in the genetically epilepsy‐prone rat

Rhythm and blues: Animal models of epilepsy and depression comorbidity

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