GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular malformation with associated capillary proliferation

Mo, Jun Qin; Dimashkieh, Haytham; Bove, Kevin E.

doi:10.1016/j.humpath.2003.09.017

Cited by 131 publications

(90 citation statements)

References 19 publications

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“…49,50 Infantile hepatic hemangiomas are classically seen on radiographic imaging as highly vascular rim-enhancing lesions and may present with elevated serum alpha-feto protein, and occasionally be mistaken for hepatoblastoma. 51 Three clinical subgroups of infantile hepatic hemangioma-focal, multifocal, and diffuse-are recognized by the Liver Hemangioma Registry of the Vascular Anomalies Center at the Children's Hospital of Boston.…”

Section: Other Pediatric Liver Tumorsmentioning

confidence: 99%

Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium

Alaggio²,

et al. 2014

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Liver tumors are rare in children, and their diagnoses may be challenging particularly because of the lack of a current consensus classification system. Systematic central histopathological review of these tumors performed as part of the pediatric collaborative therapeutic protocols has allowed the identification of histologic subtypes with distinct clinical associations. As a result, histopathology has been incorporated within the Children's Oncology Group (COG) protocols, and only in the United States, as a risk-stratification parameter and for patient management. Therefore, the COG Liver Tumor Committee sponsored an International Pathology Symposium in March 2011 to discuss the histopathology and classification of pediatric liver tumors, and hepatoblastoma in particular, and work towards an International Pediatric Liver Tumors Consensus Classification that would be required for international collaborative projects. Twenty-two pathologists and experts in pediatric liver tumors, including those serving as central reviewers for the COG, European Socié té Internationale d'Oncologie Pé diatrique, Gesellschaft fü r Pä diatrische Onkologie und Hä matologie, and Japanese Study Group for Pediatric Liver Tumors protocols, as well as pediatric oncologists and surgeons specialized in this field, reviewed more than 50 pediatric liver tumor cases and discussed classic and newly reported entities, as well as criteria for their classification. This symposium represented the first collaborative step to develop a classification that may lead to a common treatment-stratification system incorporating tumor histopathology. A standardized, clinically meaningful classification will also be necessary to allow the integration of new biological parameters and to move towards clinical algorithms based on patient characteristics and tumor genetics, which should improve future patient management and outcome.

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Section: Other Pediatric Liver Tumorsmentioning

confidence: 99%

Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium

Alaggio²,

et al. 2014

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“…In 2007, Christison-Lagay et al [3] from Vascular Anomalies Center in Boston Children's Hospital postulated three principal categories of HH (focal, multifocal, and diffuse) and a clinical practice algorithm. These lesions share the same patterns of growth, histological findings and involution as their cutaneous counterparts, the infantile hemangioma (IH) and the Rapidly Involuting Congenital Hemangioma (RICH) [4][5][6] . Focal hemangioma seems to correspond with a RICH, a vascular tumor completed formed at birth with no postnatal growth in which involution is normally observed in the first 12-18 mo after birth.…”

Section: Hepatic Hemangiomamentioning

confidence: 99%

Differential diagnosis and management of liver tumors in infants

Fernández-Pineda

Cabello-Laureano

2014

WJH

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During the first year of life, most of the liver neoplasms are benign in origin, but some of these histologically benign lesions may be challenging in their management. Although most hepatic hemangiomas can be safely observed until involution is documented, some patients will need treatment due to progressive hepatomegaly, hypothyroidism and/or cardiac failure. Large mesenchymal hamartomas may require extensive hepatic resection and an appropriate surgical plan is critical to obtain good results. For malignant neoplasms such as hepatoblastoma, complete surgical resection is the mainstay of curative therapy. The decision about whether to perform an upfront or delayed resection of a primary liver malignant tumor is based on many considerations, including the ease of resection, surgical expertise, tumor histology and stage, and the likely chemosensitivity of the tumor. This article reviews the initial management of the more common hepatic tumors of infancy, focusing on the differential diagnosis and treatment options.

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“…Although the patient was clinically euthyroid, because the lesion grew larger over the next 3 months (Fig. 3a) and a heterogeneous pattern was observed in a contrast study, the possibility of malignant transformation was of concern [22]. Surgical resection was, therefore, performed at the age of 23 months.…”

Section: Case Reportmentioning

confidence: 99%

Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism

et al. 2009

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show abstract

GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular malformation with associated capillary proliferation

Cited by 131 publications

References 19 publications

Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium

Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium

Differential diagnosis and management of liver tumors in infants

Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism

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