GluN2A-ERK-mTOR pathway confers a vulnerability to LPS-induced depressive-like behaviour

Francija, Ester; Lukić, Iva; Petrović, Zorica D.; Brkic, Zeljka; Mitić, Miloš; Radulović, Jelena; Adžić, Miroslav

doi:10.1016/j.bbr.2021.113625

Cited by 5 publications

(1 citation statement)

References 37 publications

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“…The mTOR signaling is paramount to the occurrence and development of several diseases, most of which are caused by mTOR overactivation. In LPS-induced depressive-like behavior, the suppression of the GluN2A-extracellular signal-regulated kinase (ERK)-mTOR signaling pathway inhibits neuroinflammation ( 51 ). Also, a significant amount of ATP produced by glycolysisactivates the mTOR signal in microglia, upregulates BDNF and TNF-α levels, and aggravates neuroinflammation ( 52 ).…”

Section: The Mtor Signaling Pathwaymentioning

confidence: 99%

Quercetin Can Improve Spinal Cord Injury by Regulating the mTOR Signaling Pathway

Wang

Botchway

et al. 2022

Front. Neurol.

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The pathogenesis of spinal cord injury (SCI) is complex. At present, there is no effective treatment for SCI, with most current interventions focused on improving the symptoms. Inflammation, apoptosis, autophagy, and oxidative stress caused by secondary SCI may instigate serious consequences in the event of SCI. The mammalian target of rapamycin (mTOR), as a key signaling molecule, participates in the regulation of inflammation, apoptosis, and autophagy in several processes associated with SCI. Quercetin can reduce the loss of myelin sheath, enhance the ability of antioxidant stress, and promote axonal regeneration. Moreover, quercetin is also a significant player in regulating the mTOR signaling pathway that improves pathological alterations following neuronal injury. Herein, we review the therapeutic effects of quercetin in SCI through its modulation of the mTOR signaling pathway and elaborate on how it can be a potential interventional agent for SCI.

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Section: The Mtor Signaling Pathwaymentioning

confidence: 99%