GLUCURONURIA IN A HERBIVOROUS MARSUPIAL <i>TRICHOSURUS VULPECULA</i>

Hinks, N. T.; Bolliger, Adolph

doi:10.1038/icb.1957.5

Cited by 19 publications

(6 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ability of glucuronic acid lactone and glucuronic acid to compete for phlorizin-sensitive aMDG uptake in the possum but not in the rat may again reflect minor differences in the structural requirements for binding to the glucose transporter. In this case it may be relevant to note that Hinks and Bolliger (1957) have shown that glucuronuria, while generally absent in eutherians, is physiologically normal in T. vulpecula. It seems unlikely, however, that significant net reabsorption of glucuronides occurs in the kidney of the possum since plasma levels of glucuronic acid and glucuronic acid lactone are negligible (Hinks and Bolliger 1957).…”

Section: Discussionmentioning

confidence: 89%

Mechanisms of Organic Acid and Monosaccharide Transport in the Kidney of the Brush-tailed Possum, Trichosurus vulpecula

Miller¹,

Morris²

1982

Aust. Jnl. Of Bio. Sci.

View full text Add to dashboard Cite

The mechanisms of organic acid and monosaccharide transport in the kidney of T. vulpecula were investigated using the renal cortical slice preparation. The kinetics, the sensitivity to inhibitors of metabolism and sodium transport, and the specificity of the concentrative uptake of p-aminohippurate and oc-methyl-n-glucoside were examined and compared with published results from studies in eutherian mammals. Some minor differences between metatherians and eutherians were noted with regard to the specificities of the renal slice uptake systems. Penicillin G, a competitor of organic acid transport in eutherian kidneys, did not interact with the marsupial uptake system, and sodium acetate, which stimulates transport in other mammals, inhibited p-aminohippurate uptake in the slice of the possum kidney. 2-Deoxy-n-glucose, which interacts with the phlorizinsensitive monosaccharide transport system in the dog, rat and rabbit kidney, had no effect on oc-methyl-n-glucoside uptake in the possum, and the magnitude of the interaction of n-fructose resembled that reported in the dog and rat but was greater than the inhibition reported in the rabbit. n-Glucuronic acid and n-glucuronic acid lactone inhibited oc-methyl-n-glucoside uptake in the possum but had no effect on uptake in rat renal slices. In consideration of the reported variability of these parameters between different classes of eutherians, it was concluded that the primary mechanisms involved in organic solute transport by the proximal nephron of metatherians and eutherians were not significantly different.

show abstract

Section: Discussionmentioning

confidence: 89%

Mechanisms of Organic Acid and Monosaccharide Transport in the Kidney of the Brush-tailed Possum, Trichosurus vulpecula

Miller¹,

Morris²

1982

Aust. Jnl. Of Bio. Sci.

View full text Add to dashboard Cite

show abstract

“…As was pointed out above it was not possible to detect, with any certainty, glucuronic acid in normal opossum urine. This was most surprising as Hinks and Bolliger (1957) claimed that Trichosurus vulpecula and other marsupials (Hinks, 1956) normally excrete considerable amounts of glucuronic acid or, more probably, some labile glucuronide. The opossum, for instance, was shown (Hinks and Bolliger, 1957) to excrete per day approximately 100 mg. of glucuronic acid as a labile glucuronide.…”

Section: Discussionmentioning

confidence: 99%

“…This was most surprising as Hinks and Bolliger (1957) claimed that Trichosurus vulpecula and other marsupials (Hinks, 1956) normally excrete considerable amounts of glucuronic acid or, more probably, some labile glucuronide. The opossum, for instance, was shown (Hinks and Bolliger, 1957) to excrete per day approximately 100 mg. of glucuronic acid as a labile glucuronide. It is difficult to account for the discrepancy between the present results and those of Hinks and Bolliger (1957) except on the basis of a diflFering diet: if this indeed be the case then it is hard to accept the claim by the latter authors that marsupials can be distinguished from eutherian mammals by the physiological glucuronuria of the former.…”

Section: Discussionmentioning

confidence: 99%

“…(Hanson, Mills and Williams, 1944). It would seem, therefore, that if there is any real difference between the marsupials and the eutheria with regard to the urinary glucuronic acid then this difference is not quantitative but qualitative in that in marsupials the urinary glucuronic acid occurs as labile glucuronides which readily reduce the normal sugar reagents (Hinks and Bolliger, 1957).…”

Section: Discussionmentioning

confidence: 99%

“…The opossum, for instance, was shown (Hinks and Bolliger, 1957) to excrete per day approximately 100 mg. of glucuronic acid as a labile glucuronide. It is difficult to account for the discrepancy between the present results and those of Hinks and Bolliger (1957) except on the basis of a diflFering diet: if this indeed be the case then it is hard to accept the claim by the latter authors that marsupials can be distinguished from eutherian mammals by the physiological glucuronuria of the former. Obviously this point requires reinvestigation but it should be noted that even if the figure given by Hinks and Bolliger (1957) of 100 mg. per day be accepted for the glucuronide content of the urine of a normal opossum, weighing 1-5-2-0 kg., this is hardly diflEerent from the mean value of 140 mg. per day for the glucuronide excretion of the rabbit, a typical eutherian mammal weighing 2-3 kg.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Arylsulphatases and Related Enzymes in the Livers of Some Lower Vertebrates

Roy

1963

Aust J Exp Biol Med

View full text Add to dashboard Cite

SUMMARY.The livers of the marsupials Trichosurus vulpecula and Phascolomis mitchelli, the monotreme Echidna aculeata, the lizard Tiliqua rugosa and the frog Rana temporaria have been studied with regard to their content of arylsulphatases and related enzymes. Type I arylsulphatases were found only in the opossum (T. vulpecula) and the lizard, in very small amounts in the latter. The enzymes were generally similar to the type I arylsulphatases of the eutherian mammals although they differed in their considerably lower pH optima which were in the region of pH 6. Type II arylsulphatases were found in all the species studied. The enzymes had the electrophoretic properties of a sulphatase B from a eutherian mammal but they were not typical of this group as their hydrolyses of nitrophenyl sulphate were not greatly activated by Cl~ ions and they seemed to combine many of the properties of the sulphatases A and B of the eutheria. It is therefore suggested that the complexity of the arylsulphatases in the eutheria is a recent development in their evolution. No steroid sulphatase could be detected in opossum liver.Opossum liver could synthesise p-nitrophenyl sulphate only extremely slowly and no synthesis of androstenolone, oestrone or testosterone sulphates could be detected. Normal opossum urine contained no detectable ester sulphates. A dose of 1-naphthol was excreted by the opossum mainly in the form of urinary glucuronides and only traces of ester sulphates were formed.INTRODUCTION.

show abstract

Digestion and energy metabolism in a small arboreal marsupial, the Greater Glider (Petauroides volans), fed high-terpeneEucalyptus foliage

Foley

1987

J Comp Physiol B

View full text Add to dashboard Cite

GLUCURONURIA IN A HERBIVOROUS MARSUPIAL TRICHOSURUS VULPECULA

Cited by 19 publications

References 3 publications

Mechanisms of Organic Acid and Monosaccharide Transport in the Kidney of the Brush-tailed Possum, Trichosurus vulpecula

Mechanisms of Organic Acid and Monosaccharide Transport in the Kidney of the Brush-tailed Possum, Trichosurus vulpecula

The Arylsulphatases and Related Enzymes in the Livers of Some Lower Vertebrates

Digestion and energy metabolism in a small arboreal marsupial, the Greater Glider (Petauroides volans), fed high-terpeneEucalyptus foliage

Contact Info

Product

Resources

About