Glucuronoxylan-mediated silver nanoparticles: green synthesis, antimicrobial and wound healing applications

Muhammad, Gulzar; Hussain, Muhammad Ajaz; Amin, Muhammad; Hussain, Syed Zajif; Hussain, Irshad; Bukhari, Syed Nasir Abbas; Naeem-ul-Hassan, Muhammad

doi:10.1039/c7ra07555c

Cited by 38 publications

(18 citation statements)

References 41 publications

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“…Some of the prominent examples of these plants are Cassia roxburghii, 66 Drosera binata Labill., 67 Indigofera aspalathoides DC., 68 Azadirachta indica A. Juss., 69 Arnebia nobilis Rech.f., 70 Melia dubia Cav., 71 Terminalia chebula Retz., 72 Lansium domesticum Corrêa, 73 Orchidantha chinensis T.L.Wu, 74 A. vera (L.) Burm.f., 75 glucuronoxylan, 76 Momordica charantia L., 77,78 Carica papaya L., 79 Cymbopogon citratus (DC.) Stapf, 80 Nyctanthes arbor-tristis L., 81 Naringi crenulata (Roxb.)…”

Section: Green-synthesized Metal Nanoparticles Using Plantsmentioning

confidence: 99%

Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems

Hajialyani¹,

Tewari²,

Sobarzo‐Sánchez³

et al. 2018

IJN

154

113

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Wound healing process is an intricate sequence of well-orchestrated biochemical and cellular phenomena to restore the integrity of the skin and subcutaneous tissue. Several plant extracts and their phytoconstituents are known as a promising alternative for wound healing agents due to the presence of diverse active components, ease of access, and their limited side effects. The development of nanotechnological methods can help to improve the efficacy of different therapeutics as well as herbal-based products. Here, we present a review of the efficacy of the plant based-nanomaterials in the management of wounds and discuss the involved therapeutic targets. For this purpose, a profound search has been conducted on in vitro, in vivo, and/or clinical evidences evaluating the efficacy and pharmacological mechanisms of natural product-based nanostructures on different types of wounds. Different pharmacological targets are involved in the wound healing effects of herbal-based nanostructures, including suppressing the production of inflammatory cytokines and inflammatory transduction cascades, reducing oxidative factors and enhancing antioxidative enzymes, and promoting neovascularization and angiogenic pathways through increasing the expression of vascular endothelial growth factor, fibroblast growth factor, and platelet-derived growth factor. Moreover, nanostructure of plant extracts and their phytochemicals can enhance their bioavailability, control their release in the form of sustained delivery systems to the wound site, and enhance the permeability of these therapeutics to the underlying skin layers, which are all necessary for the healing process. Overall, various plant extracts and their natural compounds, used in nanoformulations, have demonstrated high activity in the management of wounds and thus can be assumed as future pharmaceutical drugs.

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Section: Green-synthesized Metal Nanoparticles Using Plantsmentioning

confidence: 99%

Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems

Hajialyani¹,

Tewari²,

Sobarzo‐Sánchez³

et al. 2018

IJN

154

113

View full text Add to dashboard Cite

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“…150,151 Many studies are designed to minimize the release of silver into the environment, since this metal is widely used in several products because it has antimicrobial potential. 152,[161][162][163] A study was carried out to investigate the controlled release of immobilized silver nanoparticles in thin layer of aluminum oxide. A 15 nm layer of this oxide is capable of inhibiting the release of silver for up to 48 h, since a 2 nm layer delayed the release for 4 h. 164 Another release study using nanoparticles was the work done by Mohammady et al, 165 obtaining nanoparticles with a mean size of 120 to 300 nm from the poly-lactide-co-glycolide polymer (PLGA).…”

Section: Nanomaterialsmentioning

confidence: 99%

Design of Immobilized Enzyme Biocatalysts: Drawbacks and Opportunities

Reis

Sousa

Serpa

et al. 2019

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The enzymatic processes are increasingly highlights, especially in the synthesis of chemical products with high added value. The enzyme immobilization can improve industrial biocatalytic processes. The immobilization of enzymes provides the production of efficient, stable biocatalysts, possibility of reuse and easy purification of the products, when compared to the free enzymes. There is a growing research for more efficient methods of enzyme immobilization. In this context, the choice of support and immobilization strategy can significantly improve the final enzymatic properties. In this review paper, we aimed to discuss the versatility of biocatalysts immobilized enzymes design, focusing on the opportunities and disadvantages for each method presented. They discussed the recent development of enzyme immobilization methods and applications relating the final properties of the produced biocatalysts with the desired goals.

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“…In another study, AgNPs were prepared using GX polysaccharide to deliver Ag to the infection site. Both GX AgNPs (50 mmol, 5 h sunlight exposure) and Band aid ® patches showed comparable wound-healing abilities [190]. The high moisturizing effect of hydrogels at neutral pH is highly beneficial for patients, preventing bandage adhesion.…”

Section: Smart Nanomaterialsmentioning

confidence: 98%

“…An AMP developed from innate immunity peptides found in the hagfish, WMR, was linked to an aliphatic residue having a lipidic tail with pH-dependent Preparation of smart wound dressing based on AgNPs-GX (gold nanoparticles-glucuronoxylan) hydrogels and their application for wound treatment. Modified from [190].…”

Section: Smart Nanomaterialsmentioning

confidence: 99%

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

2020

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Bacterial infections occur when wound healing fails to reach the final stage of healing, which is usually hindered by the presence of different pathogens. Different topical antimicrobial agents are used to inhibit bacterial growth due to antibiotic failure in reaching the infected site, which is accompanied very often by increased drug resistance and other side effects. In this review, we focus on antimicrobial peptides (AMPs), especially those with a high potential of efficacy against multidrug-resistant and biofilm-forming bacteria and fungi present in wound infections. Currently, different AMPs undergo preclinical and clinical phase to combat infection-related diseases. AMP dendrimers (AMPDs) have been mentioned as potent microbial agents. Various AMP delivery strategies that are used to combat infection and modulate the healing rate—such as polymers, scaffolds, films and wound dressings, and organic and inorganic nanoparticles—have been discussed as well. New technologies such as Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated protein (CRISPR-Cas) are taken into consideration as potential future tools for AMP delivery in skin therapy.

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Glucuronoxylan-mediated silver nanoparticles: green synthesis, antimicrobial and wound healing applications

Abstract: Hydrogel forming polysaccharides are attracting attention for the design of diverse nature silver nanoparticles (Ag NPs) with potential biological applications.

Cited by 38 publications

References 41 publications

Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems

Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems

Design of Immobilized Enzyme Biocatalysts: Drawbacks and Opportunities

An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound Infections

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