Glucuronic acid conjugates

Human serum albumin: From bench to bedside

“…However, glucuronide conjugates are intrinsically reactive molecules (both in vivo and in vitro) that can undergo a number of reactions; by far, hydrolysis back to the parent aglycon is the predominating process (Knadler and Hall, 1991;Dubois-Presle et al, 1995;Bailey and Dickinson, 2003;di Masi et al, 2009). Interestingly, SA has been reported: (i) to facilitate the isomerization and the stereoselective hydrolysis of glucuronide conjugates, and (ii) to act as a scavenger of glucuronide conjugates decreasing their plasma levels by reversible and/or irreversible binding (Dubois-Presle et al, 1995;Bedford, 1998;Mizuma et al, 1998Mizuma et al, , 1999Bueno et al, 2009). …”

Profiling urinary metabolites of naproxen by liquid chromatography–electrospray mass spectrometry

“…The major reason for this was that intact glucuronide conjugates were regarded as "detoxified" drug metabolites. However, several examples of biologically active or toxic glucuronide conjugates of drugs came to light [20], and it is clearly an oversimplification to regard all glucuronide conjugates as detoxification products.…”

Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases

“…RPLC has been broadly used for glucuronides analyses [21][22][23][24] and particularly for highly lipophilic stationary phases such as octadecyl-bonded phases C 18 [25][26][27][28]. More recently, RPLC, hydrophilic interaction liquid chromatography (HILIC), aqueous normal phase chromatography (ANPC), and subcritical fluid chromatography (SFC) were compared for their abilities to analyze UGT substrates and their corresponding glucuroconjugates [15].…”