Glucosylated nanomicelles target glucose-avid pediatric patient-derived sarcomas

Bukchin, Alexandra; Pascual‐Pasto, Guillem; Cuadrado‐Vilanova, Maria; Castillo‐Ecija, Helena; Monterrubio, Carles; Olaciregui, Nagore G.; Vilà-Ubach, Mònica; Ordeix, Laia; Mora, Jaume; Sosnik, Alejandro

doi:10.1016/j.jconrel.2018.02.034

Cited by 27 publications

(70 citation statements)

References 46 publications

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“…In this context, the observed quenching constitutes additional evidence of the successful incorporation of T1107 into the ceramic nanoparticle bulk . In a similar way, the use of a glucosylated derivative of T1107 that shows active targeting in pediatric patient‐derived solid tumors in vivo and a 20 day aged oxo‐organo complex produce hybrid nanoparticles with a size of 160 nm, which is slightly larger though in the same range shown by counterparts synthesized with the pristine amphiphile.…”

Section: Resultsmentioning

confidence: 70%

“…PEO–PPO copolymers are among the most well‐investigated amphiphilic biomaterials for drug delivery and other biomedical applications owing to their ability to self‐assemble and form polymeric nanomicelles and physical gels, their good cell and biocompatibility and approval by the US Food and Drug Administration as food additives, pharmaceutical ingredients and agricultural products . T1107 is a branched derivative that shows very good cell compatibility in vitro and encapsulation capacity of a plethora of hydrophobic drugs and, at the same time, multifunctionality that enables the modification of the polymeric micelle surface with ligands to track cell trafficking and confer active drug targeting properties in vivo . Moreover, PEO–PPO copolymers have been used for the surface modification of hydrophobic nanoparticles with poly(ethylene glycol) (PEG), a process known as PEGylation, using the physical entrapment method .…”

Section: Resultsmentioning

confidence: 99%

“…Visualization of the fluorescence was carried out with a Spectroline ENF‐280C/FE lamp (Westbury, NY) at λ = 365 nm. A glucosylated derivative of T1107 was synthesized by the microwave‐assisted ring opening reaction of T1107 with d ‐(+)‐glucono‐1,5‐lactone (Alfa Aesar, Hayesham, UK) using tin(II) 2‐ethylhexanoate (SnOct 2 , Sigma‐Aldrich) as catalyst in a Multiwave Pro Microwave Reaction System with 16HF100 rotor (Anton Paar, Ashland, VA), as described elsewhere …”

Section: Methodsmentioning

confidence: 99%

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Hybrid Titanium Oxide/Polymer Amphiphilic Nanomaterials with Controlled Size for Drug Encapsulation and Delivery

Melnitzer

Sosnik

2018

Adv Funct Materials

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This work describes for the first time the synthesis of hybrid drug-loaded TiO 2 /polymer amphiphilic nanoparticles of finely controlled size utilizing a simple and reproducible sol-gel process that comprises the formation of a titanium(IV)/acetone oxo-organo complex followed by its blending with an amphiphilic poly(ethylene oxide)-b-poly(propylene oxide) block copolymer in acetone and its aqueous-phase nanoprecipitation. The size of the hybrid nanoparticles is governed by the complex aging, e.g., hybrid nanoparticles display diameter between 228 and 53 nm for aging of 1 and 36 days, respectively (dynamic light scattering). In addition, they show excellent physical stability in water owing to the coating of the surface with poly(ethylene oxide) blocks of the copolymer. Conversely, polymer-free TiO 2 particles are large and precipitate fast. Incorporation of a model hydrophobic drug, nitazoxanide, to the precursor solution results in hybrid nanoparticles containing 12.9% w/w cargo that is released following a bimodal profile. High-resolution transmission electron microscopy (Titan Cubed Themis G2 300) analysis reveals the porous amorphous nanostructure of these novel hybrids and colocalization of drug and copolymer in the nanoparticle bulk. Finally, upon ultrasonication, our hybrid nanoparticles produce reactive oxygen species in vitro which paves the way for their use in sonodynamic and drug release therapies.

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Section: Resultsmentioning

confidence: 70%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Hybrid Titanium Oxide/Polymer Amphiphilic Nanomaterials with Controlled Size for Drug Encapsulation and Delivery

Melnitzer

Sosnik

2018

Adv Funct Materials

Self Cite

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show abstract

“…Furthermore, the stimuli-responsive coordination of micelles facilitates the controlled release of drugs from micelle-based nanoplatforms. Therefore, intelligent PMs with stimuli-responsive behavior or tumor-targeted ligands have gained considerable research attention as novel carriers for drug delivery [ 274 , 275 , 276 , 277 ]. As a result, a wide variety of micelle-based, stimuli-responsive, theranostic modalities has been reported to target and eradicate cancer-causing cells [ 278 ].…”

Section: Stimuli-responsive Polymeric Nanocarriers For Theranosismentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

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“…ere are a number of studies based on patient-derived cells (PDC) and patient-derived xenograft (PDX) model in vivo. However, most of the described investigations are focused on establishment of new cell line derived from patient tumor (for example, see [63][64][65][66][67], on preclinical studies of novel or repurposed drug/combination of drugs in vitro [68][69][70][71] and in vivo [72][73][74]). Only a few studies address the optimization of STS treatment.…”

Section: Drug Sensitivity Testing On Patient-derived Sts Cellsmentioning

confidence: 99%

Current Approaches for Personalized Therapy of Soft Tissue Sarcomas

Кирсанов

Lesovaya

Fetisov

et al. 2020

Sarcoma

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Soft tissue sarcomas (STS) are a highly heterogeneous group of cancers of mesenchymal origin with diverse morphologies and clinical behaviors. While surgical resection is the standard treatment for primary STS, advanced and metastatic STS patients are not eligible for surgery. Systemic treatments, including standard chemotherapy and newer chemical agents, still play the most relevant role in the management of the disease. Discovery of specific genetic alterations in distinct STS subtypes allowed better understanding of mechanisms driving their pathogenesis and treatment optimization. This review focuses on the available targeted drugs or drug combinations based on genetic aberration involved in STS development including chromosomal translocations, oncogenic mutations, gene amplifications, and their perspectives in STS treatment. Furthermore, in this review, we discuss the possible use of chemotherapy sensitivity and resistance assays (CSRA) for the adjustment of treatment for individual patients. In summary, current trends in personalized management of advanced and metastatic STS are based on combination of both genetic testing and CSRA.

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Glucosylated nanomicelles target glucose-avid pediatric patient-derived sarcomas

Cited by 27 publications

References 46 publications

Hybrid Titanium Oxide/Polymer Amphiphilic Nanomaterials with Controlled Size for Drug Encapsulation and Delivery

Hybrid Titanium Oxide/Polymer Amphiphilic Nanomaterials with Controlled Size for Drug Encapsulation and Delivery

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Current Approaches for Personalized Therapy of Soft Tissue Sarcomas

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