Glucosinolates in crucifer vegetables: turnips and rutabagas

Carlson, Diana G.; Daxenbichler, M. E.; VanEtten, C. H.; Tookey, H. L.; Williams, Paul H.

doi:10.1021/jf00108a034

Cited by 86 publications

(54 citation statements)

References 9 publications

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“…Cruciferous vegetables contain bioactive precursor compounds known as glucosinolates (Table 1). [15][16][17][18][19] Major glucosinolates are glucobrassicin and glucoraphanin, the latter of which is a derivative of isothiocyanates, 20 including sulforaphane. The average human consumption of glucosinolates from food sources is estimated at 0.5lM/ kg/d.…”

Section: Metabolism Of Diindolylmethane From Indole-3-carbinolmentioning

confidence: 99%

Chemopreventive properties of 3,3′-diindolylmethane in breast cancer: evidence from experimental and human studies

Thomson

Ström

2016

Nutr Rev

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Diet is a modifiable factor associated with the risk of several cancers, with convincing evidence showing a link between diet and breast cancer. The role of bioactive compounds of food origin, including those found in cruciferous vegetables, is an active area of research in cancer chemoprevention. This review focuses on 3,3 0 -diindolylmethane (DIM), the major bioactive indole in crucifers. Research of the cancerpreventive activity of DIM has yielded basic mechanistic, animal, and human trial data. Further, this body of evidence is largely supported by observational studies. Bioactive DIM has demonstrated chemopreventive activity in all stages of breast cancer carcinogenesis. This review describes current evidence related to the metabolism and mechanisms of DIM involved in the prevention of breast cancer. Importantly, this review also focuses on current evidence from human observational and intervention trials that have contributed to a greater understanding of exposure estimates that will inform recommendations for DIM intake.

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Section: Metabolism Of Diindolylmethane From Indole-3-carbinolmentioning

confidence: 99%

Chemopreventive properties of 3,3′-diindolylmethane in breast cancer: evidence from experimental and human studies

Thomson

Ström

2016

Nutr Rev

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“…italica group has also been reported. Most studies report glucoraphanin or less commonly glucobrassicin as the predominant glucosinolate in broccoli [22,71,75,83,87,131,147,155,177]. In the study of Schonhof et al (2004) glucobrassicin was the predominant glucosinolate in the purple variety Viola [155], whilst neoglucobrassicin was the predominant glucosinolate detected in 3 cultivars including cv.…”

Section: Crop and Cultivarmentioning

confidence: 99%

On farm and fresh produce management

Reilly

2013

Handbook of Plant Food Phytochemicals

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“…Phenethyl isothiocyanate (PEITC), found as a glucosinolate in many cruciferous vegetables, such as watercress, cauliflower, Brussels sprouts, cabbage, etc. is a potent inhibitor of the metabolic activation of nitrosamine carcinogens and DNA methylation in vivo and in vitro (Carlson et al, 1981;Hanley et al, 1983;Stoner et al, 1991). Dietary administration of PEITC at concentrations of 3.0 mmol/kg diet or greater completely inhibits NMBA-induced esophageal tumorigenesis in the rat , and lower concentrations were also effective (Wilkinson et al, 1995).…”

Section: Agents That Inhibit Tumor Initiation In Rat Esophagusmentioning

confidence: 99%

Chemoprevention of esophageal squamous cell carcinoma

Stoner

Wang

Chen

2007

Toxicology and Applied Pharmacology

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Esophageal squamous cell carcinoma (SCC) is responsible for approximately one-sixth of all cancerrelated mortality worldwide. This malignancy has a multifactorial etiology involving several environmental, dietary and genetic factors. Since esophageal cancer has often metastasized at the time of diagnosis, current treatment modalities offer poor survival and cure rates. Chemoprevention offers a viable alternative that could well be effective against the disease. Clinical investigations have shown that primary chemoprevention of this disease is feasible if potent inhibitory agents are identified. The Fischer 344 (F-344) rat model of esophageal SCC has been used extensively to investigate the biology of the disease, and to identify chemopreventive agents that could be useful in human trials. Multiple compounds that inhibit tumor initiation by esophageal carcinogens have been identified using this model. These include several isothiocyanates, diallyl sulfide and polyphenolic compounds. These compounds influence the metabolic activation of esophageal carcinogens resulting in reduced genetic (DNA) damage. Recently, a few agents have been shown to inhibit the progression of preneoplastic lesions in the rat esophagus into tumors. These agents include inhibitors of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF) and c-Jun [a component of activator protein-1 (AP-1)]. Using a food based approach to cancer prevention, we have shown that freeze-dried berry preparations inhibit both the initiation and promotion/progression stages of esophageal SCC in F-344 rats. These observations have led to a clinical trial in China to evaluate the ability of freeze-dried strawberries to influence the progression of esophageal dysplasia to SCC.

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Glucosinolates in crucifer vegetables: turnips and rutabagas

Cited by 86 publications

References 9 publications

Chemopreventive properties of 3,3′-diindolylmethane in breast cancer: evidence from experimental and human studies

Chemopreventive properties of 3,3′-diindolylmethane in breast cancer: evidence from experimental and human studies

On farm and fresh produce management

Chemoprevention of esophageal squamous cell carcinoma

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