?-Glucosidase inhibitors

Schmidt, Delf; Frommer, W.; Junge, Bodo; Müller, Lutz; Wingender, W.; Truscheit, Ernst; Schafer, Dorothy A.

doi:10.1007/bf00483561

Cited by 412 publications

(160 citation statements)

References 6 publications

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“…Acarbose (BAY-g-5421) is a complex oligosaccharide of microbial origin [1] which delays starch digestion and which has anti-sucrase and anti-maltase activities [2][3][4]. Short-term metabolic studies have suggested that Acarbose may be a useful additional treatment for diabetic patients [5][6][7].The aim of the present study was to investigate the potential benefits of Acarbose in insulin dependent diabetics over a period of two months.…”

Section: Key-wordsmentioning

confidence: 99%

Improvement of metabolic control in insulin dependent diabetics treated with the ?-glucosidase inhibitor Acarbose for two months

1981

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Summary. Acarbose, an a-glucosidase inhibitor, delays starch digestion and inhibits intestinal sucrase and maltase activity. Twenty-eight insulin dependent diabetics were given Acarbose (3 x 100 mg daily) over a two month period, preceded and followed by a two month placebo period. Acarbose reduced post-breakfast and post-dinner blood glucose values by 25% (p < 0.001) and 24% (p < 0.05) respectively. It also significantly reduced mean daily blood glucose by 18% (p < 0.05) and mean amplitude of glycaemic excursions from 8.0 _+ 0.6 to 5.5 + 0.4 mmol/1 (p <0.0005). Weight did not change significantly. Daily caloric and carbohydrate intake remained constant throughout the study while insulin requirements decreased slightly but significantly. Out of the 28 patients, 18 had absent while ten had slight residual B cell function as assessed by plasma C-peptide measurements. Treatment with Acarbose did not significantly affect residual B cell function. The beneficial effect of Acarbose on blood glucose control was seen in patients both with and without residual B cell secretion. The major side-effect was flatulence which was never severe enough to interrupt treatment, but led to a 50% reduction of the dose in one patient. It is concluded that Acarbose represents a useful additional means of improving metabolic control in insulin dependent diabetics.

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Section: Key-wordsmentioning

confidence: 99%

Improvement of metabolic control in insulin dependent diabetics treated with the ?-glucosidase inhibitor Acarbose for two months

1981

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“…Dear Sir, A lowered postprandial rise of blood glucose following the ingestion of an a-glucosidase inhibitor (Acarbose, Bay g 5421, [1]) has been described in patients with diabetes mellitus [2][3][4][5][6]. The drug appears to be less effective, however, following its prolonged administration in patients with Type 2 diabetes [3].…”

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confidence: 99%

Long-term treatment of sulphonylurea-treated diabetics with the ?-glucosidase inhibitor Bay g 5421 (Acarbose)

1981

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“…For inoculation, a colony of about 1 × 1 cm 2 from a freshly prepared agar plate was inoculated into a 500 mL Erlenmeyer flask containing 100 ml of seed medium and cultivated at 28 4 Cl on acarbose production was carried out at initial pH of 7.4. After the addition of 0.1 M NH 4 Cl at 72 h, the pH was adjusted to 7.0 with 2 M NaOH.…”

Section: Medium and Culture Conditionsmentioning

confidence: 99%

Influence of Ammonium Salt and Fermentation pH on Acarbose Yield from <i>Streptomyces</i> M37

Ren¹,

Chen²,

Tong³

2015

Trop. J. Pharm Res

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?-Glucosidase inhibitors

Cited by 412 publications

References 6 publications

Improvement of metabolic control in insulin dependent diabetics treated with the ?-glucosidase inhibitor Acarbose for two months

Improvement of metabolic control in insulin dependent diabetics treated with the ?-glucosidase inhibitor Acarbose for two months

Long-term treatment of sulphonylurea-treated diabetics with the ?-glucosidase inhibitor Bay g 5421 (Acarbose)

Influence of Ammonium Salt and Fermentation pH on Acarbose Yield from <i>Streptomyces</i> M37

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