Glucose transporter 1 in rheumatoid arthritis and autoimmunity

Zezina, Ekaterina; Sercan, Özen; Herrmann, Matthias; Biesemann, Nadine

doi:10.1002/wsbm.1483

Cited by 29 publications

(18 citation statements)

References 115 publications

(205 reference statements)

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“…Since then, it has come more and more into the focus of immune‐medical research due to its potential implications for many auto‐immune disorders (e.g. Katsiougiannis et al., 2019; Weyand & Goronzy, 2020; Zezina et al., 2020) while also discussing the evolutionary perspective of immunometabolism (Wang, Luan, et al, 2019; Wang, Ping, et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Climate change facilitates a parasite’s host exploitation via temperature‐mediated immunometabolic processes

Scharsack

Wieczorek

Schmidt‐Drewello

et al. 2020

Global Change Biology

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Global climate change can influence organismic interactions like those between hosts and parasites. Rising temperatures may exacerbate the exploitation of hosts by parasites, especially in ectothermic systems. The metabolic activity of ectotherms is strongly linked to temperature and generally increases when temperatures rise. We hypothesized that temperature change in combination with parasite infection interferes with the host's immunometabolism. We used a parasite, the avian cestode Schistocephalus solidus, which taps most of its resources from the metabolism of an ectothermic intermediate host, the three-spined stickleback. We experimentally exposed sticklebacks to this parasite, and studied liver transcriptomes 50 days after infection at 13°C and 24°C, to assess their immunometabolic responses. Furthermore, we monitored fitness parameters of the parasite and examined immunity and body condition of the sticklebacks at 13°C, 18°C and 24°C after 36, 50 and 64 days of infection. At low temperatures (13°C), S. solidus growth was constrained, presumably also by the more active stickleback's immune system, thus delaying its infectivity for the final host to 64 days. Warmer temperature (18°C and 24°C) enhanced S. solidus growth, and it became infective to the final host already after 36 days. Overall, S. solidus produced many more viable offspring after development at elevated temperatures. In contrast, stickleback hosts had lower body conditions, and their immune system was less active at warm temperature. The stickleback's liver transcriptome revealed that mainly metabolic processes were differentially regulated between temperatures, whereas immune genes were not strongly affected. Temperature effects on gene expression were strongly enhanced in infected sticklebacks, and even in exposed-but-not-infected hosts. These data suggest that the parasite exposure in concert with rising temperature, as to be expected with global climate change, shifted the host's immunometabolism, thus providing nutrients for the enormous growth of the parasite and, at the same time suppressing immune defence.

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Section: Introductionmentioning

confidence: 99%

Climate change facilitates a parasite’s host exploitation via temperature‐mediated immunometabolic processes

Scharsack

Wieczorek

Schmidt‐Drewello

et al. 2020

Global Change Biology

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“…Typically, upregulation of GLU1 and increased glucose uptake have been recognized in RA, SLE, and psoriasis. The interference of glycolysis with GLU1 knockout or inhibitor displayed a therapeutic potential and improved the autoimmune phenotype in animal models ( 153 ).…”

Section: The Interaction Of Glucose Metabolism and Intestinal Bacteri...mentioning

confidence: 99%

Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases

Wang

Yang

et al. 2022

Front. Immunol.

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Carbohydrates serve as important energy sources and structural substances for human body as well as for gut microbes. As evidenced by the advances in immunometabolism, glucose metabolism and adenosine triphosphate (ATP) generation are deeply involved in immune cell activation, proliferation, and signaling transduction as well as trafficking and effector functions, thus contributing to immune response programming and assisting in host adaption to microenvironment changes. Increased glucose uptake, aberrant expression of glucose transporter 1 (e.g., GLU1), and abnormal glycosylation patterns have been identified in autoimmunity and are suggested as partially responsible for the dysregulated immune response and the modification of gut microbiome composition in the autoimmune pathogenesis. The interaction between gut microbiota and host carbohydrate metabolism is complex and bidirectional. Their impact on host immune homeostasis and the development of autoimmune diseases remains to be elucidated. This review summarized the current knowledge on the crosstalk of glucose metabolism and glycosylation in the host with intestinal microbiota and discussed their possible role in the development and progression of autoimmune diseases. Potential therapeutic strategies targeting glucose metabolism and glycosylation in modulating gut ecosystem and treating autoimmune diseases were discussed as well.

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“…There is growing evidence that metabolism plays a critical role in RA. Joints from RA patients have increased uptake of glucose, along with upregulation of glycolysis in fibroblast-like synoviocytes (FLS) [7][8][9]. We have recently described induction of glycolytic genes and hypoxia-induced factor 1 alpha (HIF1A) after TNF (tumor necrosis factor alpha) stimulation of RA-FLS [10].…”

Section: Introductionmentioning

confidence: 99%

Multi-omics profiling of collagen-induced arthritis mouse model reveals early metabolic dysregulation via SIRT1 axis

Freitag

Asbrand

et al. 2022

Preprint

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Rheumatoid arthritis (RA) is characterized by joint infiltration of immune cells and synovial inflammation which leads to progressive disability. Current treatments improve the disease outcome, but the unmet medical need is still high. New discoveries over the last decade have revealed the major impact of cellular metabolism on immune cell functions. So far, a comprehensive understanding of metabolic changes during disease development, especially in the diseased microenvironment, is still limited. Therefore, we studied the longitudinal metabolic changes during the development of murine arthritis integrating metabolomics and bulk RNA-seq data. We identified an early change in macrophage pathways which was accompanied by oxidative stress, a drop in NAD+ level and induction of glucose transporters. We discovered inhibition of SIRT1, a NAD-dependent histone deacetylase and confirmed its dysregulation in human macrophages and synovial tissue of RA patients. Mining this database should enable the discovery of novel metabolic targets and therapy opportunities in RA.

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Glucose transporter 1 in rheumatoid arthritis and autoimmunity

Cited by 29 publications

References 115 publications

Climate change facilitates a parasite’s host exploitation via temperature‐mediated immunometabolic processes

Climate change facilitates a parasite’s host exploitation via temperature‐mediated immunometabolic processes

Glucose metabolism and glycosylation link the gut microbiota to autoimmune diseases

Multi-omics profiling of collagen-induced arthritis mouse model reveals early metabolic dysregulation via SIRT1 axis

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