“…In vitro studies with partially purified preparations of GTF showed stimulation of glucose metabolism in several tissues: GTF potentiated glucose oxidation to CO 2 in adipocytes [Anderson et al, 1978;Davies et al, 1985]and adipose tissue [Evans et al, 1973;Toepfer et al, 1977]. Several groups found an increased glucose transport to cardiomyocytes [Fischer et al, 1992], to yeast cells [Mirsky and Berdicevsky, 1994], and to adipocytes and myocytes [Weksler-Zangen et al, 2012], by the addition of GTF.Our group examined the oral administration of GTF in animal models for both types of diabetes, and found high and rapid anti-diabetic, hypolipidemic and antioxidant activity in diabetic untreated retinas [Mirsky, 2012],with a remarkable reduction in the complications of diabetes: nephropathy [Nakhoul et al, 2006],and retinopathy [Mirsky, 2012].In addition, in vitro studies showed insulin mimetic and insulin potentiating activity for GTF [Weksler-Zangen et al, 2012;Mirsky, 2012],…”