Glucose Tolerance Curves in Neuropsychiatric Patients

Balter, Abraham M.

doi:10.2337/diab.10.2.100

Cited by 22 publications

(7 citation statements)

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“…When the effect of age on SomogyiNelson readings was studied in both curve type groups, we found no indication that the quantity of blood sugar was influenced by age. A previous study 10 showed that an abnormal response to the glucose tolerance test occurs more frequently among the older subjects. The present study shows that once the individual is in the abnormal group, the degree of abnormality is not related to age.…”

Section: Discussionmentioning

confidence: 97%

Blood Saccharoid Content in Neuropsychiatric Patients

Baiter

Efron

1965

Diabetes

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Glucose tolerance tests were obtained in 430 psychiatric inpatients with both the Folin-Wu and Somogyi-Nelson methods on the same blood sample. Blood was drawn in the fasting state and at one-half, one, two and three hours after ingestion of glucose. By the Somogyi-Nelson method the curves of 170 subjects were classified as normal and 260 as abnormal. The saccharoid content of the blood was operationally defined as the Folin-Wu value minus the Somogyi-Nelson value with the latter taken as the "true" blood sugar. In marked contrast to previous studies of others with nonpsychiatric subjects the mean saccharoid values were not constant in either the normal or abnormal group but varied significantly from one time period to the next. The variations in saccharoids observed in the abnormal group over the testing interval were different from the variations for the normals. Within each group, there was no association between age and either saccharoid content or blood sugar level. Saccharoid content was not related to deviations from average weight. A "rule of thumb" suggested by the data is that if one wants to estimate "true glucose" from the Folin-Wu with 95 per cent certainty, then the constant to subtract varies with the time interval after glucose ingestion and is in the range of approximately 0 to 47 mg./lOO ml. Estimation of true blood sugar content from a Folin-Wu reading that is close to the borderline range by subtraction of a constant is seen as an extremely dubious procedure. DIABETES

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Section: Discussionmentioning

confidence: 97%

Blood Saccharoid Content in Neuropsychiatric Patients

Baiter

Efron

1965

Diabetes

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“…People with schizophrenia may be at increased risk for type 2 diabetes because of the side effects of antipsychotic medication, underlying predisposition, and less healthy lifestyles. mia after glucose challenge, but also prolonged hyperinsulinemia and elevated serum lactic acid levels, consistent with the presence of insulin resistance and abnormal glucose metabolism [9][10][11]. However, it is still not known whether the abnormalities in glucose metabolism are due to an increased prevalence of high-risk lifestyle factors, or if there is an intrinsic disturbance in glucose metabolism in these patients that ultimately becomes manifest.…”

Section: Hyperglycemia In Schizophrenic Patientsmentioning

confidence: 99%

Hyperglycemia with antipsychotic treatment

Sathyaprakash¹,

Henry²

2004

Curr Diab Rep

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Diabetes and mental disorders are common chronic illnesses in the United States. Recently, the introduction of a new class of atypical antipsychotic medications has been a major treatment advance for patients with mental disorders. Because of increased use of atypical antipsychotic medications, new and unanticipated side effects have often appeared. Treatment-emergent diabetes has been described for conventional and atypical antipsychotics. People with schizophrenia may be at increased risk for type 2 diabetes because of the side effects of antipsychotic medication, underlying predisposition, and less healthy lifestyles.

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“…Conditions recommended for the conduct of the test [40] and criteria of normality for the different methods are now available [17]. These criteria, however, are open to criticism: distinction between normal subjects and chemical diabetics [38] remains arbitrary [8,9], and progressive reduction of carbohydrate tolerance with advancing age [1,2,3,4,7,10,11,14,17,20,21,22,23,25,37,39,43,44,45,46,47,49,50] is not taken into account. This reduction of carbohydrate tolerance with age appears to some authors to be so general, that they think it reasonable to make the criteria of normality age-dependent [4,7,22,37,49].…”

Section: Beeinflussung Der Oralen Glueosebelastung (Mit 50 G Glucose)mentioning

confidence: 99%