Glucose-Sensitive Aggregates Formed by Poly(ethylene oxide)-<i>block</i>-poly(2-glucosyl- oxyethyl acrylate) with Concanavalin A in Dilute Aqueous Medium

You, Liangchen; Lu, Feng-Zhu; Li, Zi‐Chen; Zhang, Wei; Li, Fu‐Mian

doi:10.1021/ma025641o

Cited by 93 publications

(52 citation statements)

References 29 publications

(50 reference statements)

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“…PNA has a high fluorescence activity in nonpolar environments, while polar solvents such as water can quench its fluorescence. 56 The CMC of the terpolymer was 15.8 mg/L at pH 5 and 4.0 mg/L at pH 7.4, indicating that at pH 5 the PDEA chains were indeed soluble, which led to a high CMC due to the presence of more water-soluble chains. At pH 7.4, the PDEA became hydrophobic and decreased the CMC.…”

Section: Fabrication Of 3lnps Via Ph-controlled Hierarchical Self-assmentioning

confidence: 93%

Multifunctioning pH‐responsive nanoparticles from hierarchical self‐assembly of polymer brush for cancer drug delivery

et al. 2008

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in Wiley InterScience (www.interscience.wiley.com).Polymer nanoparticles are extensively explored as drug carriers but they generally have issues of premature burst drug release, slow cellular uptake, and retention in acidic intracellular compartments. Herein, we report multifunctioning three-layered nanoparticles (3LNPs) that can overcome these problems. The 3LNPs have a poly(e-caprolactone) (PCL) core, a pH-responsive poly[2-(N,N-diethylamino)ethyl methacrylate](P-DEA) middle layer and a polyethylene glycol (PEG) outer layer. The pH-responsive PDEA layer is insoluble at pH above 7 but becomes positively charged and soluble via protonation at pH lower than 6.5. Thus, this layer has three functions: it covers on the PCL core inhibiting the premature burst drug release at the physiological pH, becomes positively charged and thus promotes endocytosis for fast cellular internalization in the acidic interstitium of solid tumors, and is highly positively charged in lysosomes to disrupt the lysosomal membrane and release the nanoparticle into the cytosol. The multifunctioning nanoparticles are an efficient carrier for cancer cytosolic drug delivery.

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Section: Fabrication Of 3lnps Via Ph-controlled Hierarchical Self-assmentioning

confidence: 93%

Multifunctioning pH‐responsive nanoparticles from hierarchical self‐assembly of polymer brush for cancer drug delivery

et al. 2008

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“…The resulting polymers were quantitatively deprotected by modified Zemplén deacetylation (MeONa in CHCl 3 /MeOH, RT). The same polymerization conditions were used to chain extend PEO macro-intiator A3 with M14 in the presence of CuBr(L3) (Entry 83, Table 2) [118]. The resulting PEO 45 -block-polyM14 27 glycopolymer was deprotected and its interaction with ConA was compared to that of polyM14 10 : While both polymers formed aggregates with the lectin, only those from PEO-block-poly(deprotected M14) were stable in water, presumably due to the hydrophilic PEO segments.…”

Section: Methodsmentioning

confidence: 99%

Synthesis of Glycopolymer Architectures by Reversible-Deactivation Radical Polymerization

Ghadban

Albertin

2013

Polymers

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This review summarizes the state of the art in the synthesis of well-defined glycopolymers by Reversible-Deactivation Radical Polymerization (RDRP) from its inception in 1998 until August 2012. Glycopolymers architectures have been successfully synthesized with four major RDRP techniques: Nitroxide-mediated radical polymerization (NMP), cyanoxyl-mediated radical polymerization (CMRP), atom transfer radical polymerization (ATRP) and reversible addition-fragmentation chain transfer (RAFT) polymerization. Over 140 publications were analyzed and their results summarized according to the technique used and the type of monomer(s) and carbohydrates involved. Particular emphasis was placed on the experimental conditions used, the structure obtained (comonomer distribution, topology), the degree of control achieved and the (potential) applications sought. A list of representative examples for each polymerization process can be found in tables placed at the beginning of each section covering a particular RDRP technique.

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“…It is reported that Con A specifically recognizes d-glucopyranoside and dmannopyranoside residues with free 3-, 4-, and 6-hydroxyl groups, and the binding of Con A with glycopolymers usually results in the Con A-cross-linked aggregates [36][37][38]. The interactions between Con A and the Gly@Au NPs were investigated in aqueous solution at room temperature.…”

Section: Recognition Properties Of the Gly@au Npsmentioning

confidence: 99%

Biomimetic glycopolymers tethered gold nanoparticles: Preparation, self-assembly and lectin recognition properties

Pei

Huang

et al. 2015

Colloids and Surfaces B: Biointerfaces

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Glucose-Sensitive Aggregates Formed by Poly(ethylene oxide)-block-poly(2-glucosyl- oxyethyl acrylate) with Concanavalin A in Dilute Aqueous Medium

Cited by 93 publications

References 29 publications

Multifunctioning pH‐responsive nanoparticles from hierarchical self‐assembly of polymer brush for cancer drug delivery

Multifunctioning pH‐responsive nanoparticles from hierarchical self‐assembly of polymer brush for cancer drug delivery

Synthesis of Glycopolymer Architectures by Reversible-Deactivation Radical Polymerization

Biomimetic glycopolymers tethered gold nanoparticles: Preparation, self-assembly and lectin recognition properties

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