Glucose Sensing in Supramolecular Chemistry

Sun, Xiaolong; James, Tony D.

doi:10.1021/cr500562m

Cited by 341 publications

(296 citation statements)

References 388 publications

(339 reference statements)

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“…Second, the dynamic changes made by these combinations can be detected by monitoring environment, and some of the extensively used reporters are optical and electrical. 1 The interactions of recognition originate from noncovalent bonding, such as hydrogen bonds, van der Waal's forces, p-p interactions, electromagnetic effects and so on, extending to covalent bonds and other sensory systems. 2,3 In recent years, using boronic acid groups to fabricate a variety of uorescent sensors have attracted great interest among scientists.…”

Section: Introductionmentioning

confidence: 99%

Recent development of boronic acid-based fluorescent sensors

et al. 2018

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As Lewis acids, boronic acids can bind with 1,2-or 1,3-diols in aqueous solution reversibly and covalently to form five or six cyclic esters, thus resulting in significant fluorescence changes. Based on this phenomenon, boronic acid compounds have been well developed as sensors to recognize carbohydrates or other substances. Several reviews in this area have been reported before, however, novel boronic acid-based fluorescent sensors have emerged in large numbers in recent years. This paper reviews new boronbased sensors from the last five years that can detect carbohydrates such as glucose, ribose and sialyl Lewis A/X, and other substances including catecholamines, reactive oxygen species, and ionic compounds. And emerging electrochemically related fluorescent sensors and functionalized boronic acid as new materials including nanoparticles, smart polymer gels, and quantum dots were also involved.By summarizing and discussing these newly developed sensors, we expect new inspiration in the design of boronic acid-based fluorescent sensors.

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Section: Introductionmentioning

confidence: 99%

Recent development of boronic acid-based fluorescent sensors

et al. 2018

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“…It is caused by insulin deficiency and hyperglycemia, and is reflected by blood glucose concentration higher or lower than the normal range (4.4-6.6 mM) [1,2]. Accordingly, tight monitoring of blood glucose levels with high accuracy is of paramount importance to the diagnosis and management of diabetes.…”

Section: Introductionmentioning

confidence: 99%

Carnation‐like CuO Hierarchical Nanostructures Assembled by Porous Nanosheets for Nonenzymatic Glucose Sensing

Zhang

Xing

et al. 2016

Electroanalysis

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Carnation‐like CuO hierarchical nanostructures assembled by ultrathin porous nanosheets were successfully fabricated via a facile solvothermal route followed with heat treatment. As‐prepared CuO nanostructures exhibited excellent catalytic activity toward glucose oxidation in the absence of any enzymes. Under the optimized conditions, the CuO‐based enzymeless glucose sensor showed high sensitivity of 3.15 mA mM−1 cm−2, low limit of detection (98 nM, S/N=3), good reproducibility, excellent selectivity and long‐time stability. The superb nonenzymatic glucose sensing performance of the CuO hierarchical nanostructures was attributed to the highly catalytically active sites at the edges and basal planes of the CuO nanosheets, facile transportation of analytes through the abundant mesopores and macropores, robust and stable hierarchical structure. Moreover, the CuO‐based enzymeless glucose sensor showed high accuracy and reliability in comparison with clinical glucometer for quantitative determination of glucose in human blood serum samples.

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“…[1b, 5] Optical sensors offer advantages over electrochemical assays since they can be constructed to be label-free, provide real-time continuous monitoring for long periods of time, are immune to electromagnetic interference, and can be calibrated internally. [6] One of the promising approaches for optical glucose sensors is to covalently incorporate glucose-sensitive chelating agents such as phenylboronic acid (PBA) derivatives [7] into matrixes such as or micro- and nanostructures including holographic thin films, [8] crystalline colloidal arrays, [9] plasmonic nanoantennas, [10] Fabry-Perot cavities, [11] fluorescent dyes, [12] and quantum dots (QDs). [13] Optical monitoring systems have also been developed in the form of solid-state optodes that report on the glucose concentration via refractive index (RI) changes.…”

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confidence: 99%

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

et al. 2017

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Optical fibers are widely used in biomedical applications for sensing, imaging, and therapies. Unlike existing solid-state optical fibers, soft polymer and hydrogel fibers offer physical and chemical properties well suited for functionalization with biomolecules and long-term implantation in the body. Here, hydrogel optical fibers are fabricated with glucose-sensitive moieties and the swelling-induced sensing is demonstrated. The core of the fiber is made of poly(acrylamide-co-poly(ethylene glycol) diacrylate) (p(AM-co-PEGDA)) hydrogel functionalized with phenylboronic acid. The complexation of the phenylboronic acid and cis diols of glucose molecules lowers the apparent pKa of the hydrogel network and increases the concentration of the boronate anions that enhances the Donnan osmotic pressure to swell and change the physical size of the hydrogel optical fiber. This mechanism is reversible through ester group dynamic covalent binding of the phenylboronic acid with glucose molecules. Dynamic changes in the effective RI of the hydrogel optical fiber are measured through light propagation loss. The sensor sensitivity to glucose concentration is 1.2 mmol L−1 over a physiological range of 1–12 mmol L−1. The biocompatible hydrogel optical fibers may be subcutaneously implanted for continuous monitoring of interstitial glucose concentrations.

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Glucose Sensing in Supramolecular Chemistry

Abstract: Joshi and Davis 33 also reported a related receptor 21, which uses a new spacer, 2,5-bis(aminomethyl)pyrrole, with an

Cited by 341 publications

References 388 publications

Recent development of boronic acid-based fluorescent sensors

Recent development of boronic acid-based fluorescent sensors

Carnation‐like CuO Hierarchical Nanostructures Assembled by Porous Nanosheets for Nonenzymatic Glucose Sensing

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

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