Abstract:Diabetes mellitus (DM) is a metabolic disorder that is one of the most common health problems in the world, primarily type 2 DM (T2DM). Metformin (MTF), as the first-line treatment of DMT2, is effective in lowering glucose levels, but its oral administration causes problems, including gastrointestinal side effects, low bioavailability, and the risk of hypoglycemia. In this study, we formulated MTF into microparticles incorporating a glucose-responsive polymer (MP−MTF−GR), which could potentially increase the b… Show more
“…Finally, DMN-SD-AMB was dried for 48 h at 37 °C. The dried DMN-SD-AMB was removed from the mold and then observed using a light microscope (Olympus CX23, Japan). , …”
Section: Methodsmentioning
confidence: 99%
“…The prepared polymer blank was poured into a rectangular mold and dried for 48 h at 37 °C. The resulting dried film was removed from the mold, and then, the volume and density of the film were calculated based on eqs and …”
Section: Methodsmentioning
confidence: 99%
“…Finally, the determination of the types of drug kinetics models in vitro such as the zero-order, first-order, Higuchi, Korsmeyer−Peppas, and Hixson−Crowell models was based on the relevant regression coefficient (R 2 ). 33 Each kinetic model equation has been attached based on Table S1. 34 2.10.…”
Section: Preparation Of Simulated Tear Fluid (Stf)mentioning
confidence: 99%
“…After that, 200 μL of the third mixture was taken and then poured into a silicon microneedle mold (number of needles 10 × 10 with a height of 700 μm) and centrifuged for 10 min at 4000 rpm as the first layer using a centrifuge (Oregon LC-04S, China). 33,35 The second layer mixture was prepared by making a PVA:PVP solution (ratio 20:25% w/w) in distilled water at 90 °C until homogeneous. The mixture for the second layer of DMN was put into the mold containing the first layer of mixture and centrifuged for 10 min at 2000 rpm.…”
Section: Preparation Of Simulated Tear Fluid (Stf)mentioning
confidence: 99%
“…Previous studies reported that microneedles made from the PVA−PVP polymer have the mechanical strength to penetrate to a depth of 200 μm. 33 These results indicated that all formulations were able to efficiently penetrate intraocularly into the stromal layer in the range of 74−574 μm. 60 The determination of the best formula for DMN-SD-AMB needs to be considered carefully based on the mechanical strength and penetration ability of each formula.…”
Section: Mechanical Strength and Penetration Ability Of The Dmn-sd-am...mentioning
“…Finally, DMN-SD-AMB was dried for 48 h at 37 °C. The dried DMN-SD-AMB was removed from the mold and then observed using a light microscope (Olympus CX23, Japan). , …”
Section: Methodsmentioning
confidence: 99%
“…The prepared polymer blank was poured into a rectangular mold and dried for 48 h at 37 °C. The resulting dried film was removed from the mold, and then, the volume and density of the film were calculated based on eqs and …”
Section: Methodsmentioning
confidence: 99%
“…Finally, the determination of the types of drug kinetics models in vitro such as the zero-order, first-order, Higuchi, Korsmeyer−Peppas, and Hixson−Crowell models was based on the relevant regression coefficient (R 2 ). 33 Each kinetic model equation has been attached based on Table S1. 34 2.10.…”
Section: Preparation Of Simulated Tear Fluid (Stf)mentioning
confidence: 99%
“…After that, 200 μL of the third mixture was taken and then poured into a silicon microneedle mold (number of needles 10 × 10 with a height of 700 μm) and centrifuged for 10 min at 4000 rpm as the first layer using a centrifuge (Oregon LC-04S, China). 33,35 The second layer mixture was prepared by making a PVA:PVP solution (ratio 20:25% w/w) in distilled water at 90 °C until homogeneous. The mixture for the second layer of DMN was put into the mold containing the first layer of mixture and centrifuged for 10 min at 2000 rpm.…”
Section: Preparation Of Simulated Tear Fluid (Stf)mentioning
confidence: 99%
“…Previous studies reported that microneedles made from the PVA−PVP polymer have the mechanical strength to penetrate to a depth of 200 μm. 33 These results indicated that all formulations were able to efficiently penetrate intraocularly into the stromal layer in the range of 74−574 μm. 60 The determination of the best formula for DMN-SD-AMB needs to be considered carefully based on the mechanical strength and penetration ability of each formula.…”
Section: Mechanical Strength and Penetration Ability Of The Dmn-sd-am...mentioning
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