Glucose-responsive mesoporous prussian blue nanoprobes coated with ultrasmall gold and manganese dioxide for magnetic resonance imaging and enhanced antitumor therapy

Ultrasmall gold decorated bimetallic metal–organic framework based nanoprobes for enhanced chemodynamic therapy with triple amplification

“…4T1 cells were incubated with ZIF-67, ZIF-67@AuNPs and ZIF-67@AuNPs@MnO 2 (0, 10, 20, 30, 40, and 50 μg mL −1 ) containing H 2 O 2 (100 μM) (pH = 6.5) for 20 h, and the viabilities were measured. 44…”

“…Cytotoxicity. The cytotoxicities of ZIF-67, ZIF-67@AuNPs and ZIF-67@AuNPs@MnO 2 were measured using the MTT assay by following a previously reported method, 44 in which the concentrations of ZIF-67, ZIF-67@AuNPs and ZIF-67@AuNPs@MnO 2 were 0, 10, 20, 30, 40, and 50 mg mL À1 , and the cell viabilities were measured using a Synergy HTX multi-mode microplate reader (Biotek, USA).…”

“…4T1 cells were incubated with ZIF-67, ZIF-67@AuNPs and ZIF-67@AuNPs@MnO 2 (0, 10, 20, 30, 40, and 50 mg mL À1 ) containing H 2 O 2 (100 mM) (pH = 6.5) for 20 h, and the viabilities were measured. 44 2.6. In vivo biocompatibility and in vivo CDT Nu/nu healthy female nude mice (16-18 g) were purchased from Beijing Vital River Laboratory Animal Technology Co., Ltd (China).…”

“…40,41 Recently, ultrasmall gold nanoparticles (AuNPs) with GOx-like activity were reported, in which the Fenton reaction rate was significantly accelerated owing to the continuous H 2 O 2 self-generation of ultrasmall AuNPs. [42][43][44] In particular, because of the structural stability of ultrasmall AuNPs and the TME-responsive structural collapse of MOFs, the constructed nanocomposite improved the CDT performance of the Fe ions, and also showed in vivo metabolism of ultrasmall AuNPs. 45 However, in order to strongly improve the efficacy of CDT, it is very necessary to design ultrasmall AuNP decorated bimetallic MOF-based nanoprobes.…”

Hybrid nanostructures based on gold nanoparticles and functional coordination polymers: Chemistry, physics and applications in biomedicine, catalysis and magnetism

“…Following a similar Au reduction method, PB@AuNPs@MnO 2 core@satellite NPs were recently prepared and applied for magnetic resonance imaging and enhanced antitumor therapy. In this heterostructure, PBs were decorated with ultra-small Au NPs to enhance the catalytic OHÁ generation for chemodynamic therapy [162].…”